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    LARP4 La ribonucleoprotein 4 [ Homo sapiens (human) ]

    Gene ID: 113251, updated on 3-Nov-2024

    Summary

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    Official Symbol
    LARP4provided by HGNC
    Official Full Name
    La ribonucleoprotein 4provided by HGNC
    Primary source
    HGNC:HGNC:24320
    See related
    Ensembl:ENSG00000161813 MIM:618657; AllianceGenome:HGNC:24320
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PP13296
    Summary
    Enables mRNA 3'-UTR binding activity and poly(A) binding activity. Involved in cytoskeleton organization; positive regulation of translation; and regulation of cell morphogenesis. Located in cytoplasmic stress granule and cytosolic small ribosomal subunit. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver (RPKM 13.3), adrenal (RPKM 12.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See LARP4 in Genome Data Viewer
    Location:
    12q13.12
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (50400885..50480004)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (50363921..50443087)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (50794668..50873787)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984505 Neighboring gene KIAA1586 pseudogene Neighboring gene family with sequence similarity 186 member A Neighboring gene MPRA-validated peak1729 silencer Neighboring gene ribosomal protein L26 pseudogene 33 Neighboring gene small nucleolar RNA, C/D box 133 Neighboring gene uncharacterized LOC124903127 Neighboring gene MPRA-validated peak1730 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4452 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6353 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4453 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6354 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6355 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:50923514-50924014 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:50924015-50924515 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6357 Neighboring gene fragile site, folic acid type, rare, fra(12)(q13.1) Neighboring gene disco interacting protein 2 homolog B Neighboring gene Sharpr-MPRA regulatory region 12282 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6359 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6360 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:51005279-51005780 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:51005781-51006280 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6361 Neighboring gene RNA, U6 small nuclear 769, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Biological functions of Circular RNA_LARP4/ Upstream frameshift 1 in development of gastric cancer. Zhang J, et al. Cell Mol Biol (Noisy-le-grand), 2024 Apr 28. PMID 38678610
    2. The RNA-binding protein LARP4 regulates cancer cell migration and invasion. Seetharaman S, et al. Cytoskeleton (Hoboken), 2016 Nov. PMID 27615744, Free PMC Article
    3. Circular RNA_LARP4 is lower expressed and serves as a potential biomarker of ovarian cancer prognosis. Zou T, et al. Eur Rev Med Pharmacol Sci, 2018 Nov. PMID 30468459
    4. circLARP4 induces cellular senescence through regulating miR-761/RUNX3/p53/p21 signaling in hepatocellular carcinoma. Chen Z, et al. Cancer Sci, 2019 Feb. PMID 30520539, Free PMC Article
    5. La-Related Protein 4 as a Suppressor for Motility of Ovarian Cancer Cells. Egiz M, et al. Tohoku J Exp Med, 2019 Jan. PMID 30686809

    See all (129) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Biological functions of Circular RNA_LARP4/ Upstream frameshift 1 in development of gastric cancer.
      Title: Biological functions of Circular RNA_LARP4/ Upstream frameshift 1 in development of gastric cancer.
    2. LARP4 is an RNA-binding protein that binds nuclear-encoded mitochondrial mRNAs to promote mitochondrial function.
      Title: LARP4 is an RNA-binding protein that binds nuclear-encoded mitochondrial mRNAs to promote mitochondrial function.
    3. CircBNC2 affects epithelial ovarian cancer progression through the miR-223-3p/ LARP4 axis.
      Title: CircBNC2 affects epithelial ovarian cancer progression through the miR-223-3p/ LARP4 axis.
    4. Circular RNA La-related RNA-binding protein 4 correlates with reduced tumor stage, as well as better prognosis, and promotes chemosensitivity to doxorubicin in breast cancer.
      Title: Circular RNA La-related RNA-binding protein 4 correlates with reduced tumor stage, as well as better prognosis, and promotes chemosensitivity to doxorubicin in breast cancer.
    5. Circular RNA_LARP4 inhibits cell migration and invasion of prostate cancer by targeting FOXO3A.
      Title: Circular RNA_LARP4 inhibits cell migration and invasion of prostate cancer by targeting FOXO3A.
    6. Circular RNA_LARP4 inhibits the progression of non-small-cell lung cancer by regulating the expression of SMAD7.
      Title: Circular RNA_LARP4 inhibits the progression of non-small-cell lung cancer by regulating the expression of SMAD7.
    7. Single molecule poly(A) tail-seq shows LARP4 opposes deadenylation throughout mRNA lifespan with most impact on short tails.
      Title: Single molecule poly(A) tail-seq shows LARP4 opposes deadenylation throughout mRNA lifespan with most impact on short tails.
    8. Circular RNA LARP4 correlates with decreased Enneking stage, better histological response, and prolonged survival profiles, and it elevates chemosensitivity to cisplatin and doxorubicin via sponging microRNA-424 in osteosarcoma.
      Title: Circular RNA LARP4 correlates with decreased Enneking stage, better histological response, and prolonged survival profiles, and it elevates chemosensitivity to cisplatin and doxorubicin via sponging microRNA-424 in osteosarcoma.
    9. Circular RNA_LARP4 Sponges miR-1323 and Hampers Progression of Esophageal Squamous Cell Carcinoma Through Modulating PTEN/PI3K/AKT Pathway.
      Title: Circular RNA_LARP4 Sponges miR-1323 and Hampers Progression of Esophageal Squamous Cell Carcinoma Through Modulating PTEN/PI3K/AKT Pathway.
    10. LARP4A recognizes polyA RNA via a novel binding mechanism mediated by disordered regions and involving the PAM2w motif, revealing interplay between PABP, LARP4A and mRNA.
      Title: LARP4A recognizes polyA RNA via a novel binding mechanism mediated by disordered regions and involving the PAM2w motif, revealing interplay between PABP, LARP4A and mRNA.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See Variation Viewer (GRCh37.p13)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC74631, DKFZp686E039

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables poly(A) binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-transcriptional regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic small ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane HDA PubMed 

    General protein information

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    Preferred Names
    la-related protein 4
    Names
    La ribonucleoprotein domain family member 4
    c-Mpl binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170803.2 → NP_001164274.1  la-related protein 4 isoform d

      See identical proteins and their annotated locations for NP_001164274.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons, compared to variant 1, resulting in a shorter protein (isoform d), compared to isoform a.
      Source sequence(s)
      AC090058
      UniProtKB/TrEMBL
      Q6P4E2, Q8TBL5
      Conserved Domains (2) summary
      cd08035
      Location:120 → 194
      LARP_4; La RNA-binding domain of La-related protein 4
      cl17169
      Location:199 → 269
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_001170804.2 → NP_001164275.1  la-related protein 4 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 3' UTR and lacks a portion of the 3' coding region, compared to variant 1. The encoded isoform (e) has a shorter C-terminus, compared to isoform a.
      Source sequence(s)
      AC090058, AW002420, AY004310, BC063479, DB061954
      Consensus CDS
      CCDS53789.1
      UniProtKB/TrEMBL
      Q6P4E2
      Related
      ENSP00000429781.1, ENST00000522085.5
      Conserved Domains (2) summary
      cd08035
      Location:120 → 194
      LARP_4; La RNA-binding domain of La-related protein 4
      cd12707
      Location:199 → 275
      RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)

    3. NM_001170808.2 → NP_001164279.1  la-related protein 4 isoform f

      See identical proteins and their annotated locations for NP_001164279.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform f), compared to isoform a.
      Source sequence(s)
      AC090058
      Consensus CDS
      CCDS53790.1
      UniProtKB/Swiss-Prot
      Q71RC2
      UniProtKB/TrEMBL
      Q6P4E2, Q8TBL5
      Related
      ENSP00000293618.8, ENST00000293618.12
      Conserved Domains (2) summary
      cd08035
      Location:120 → 194
      LARP_4; La RNA-binding domain of La-related protein 4
      cd12707
      Location:199 → 275
      RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)

    4. NM_001330415.2 → NP_001317344.1  la-related protein 4 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a longer protein (isoform g), compared to isoform a.
      Source sequence(s)
      AC090058
      Consensus CDS
      CCDS81690.1
      UniProtKB/Swiss-Prot
      Q71RC2
      Related
      ENSP00000415464.3, ENST00000429001.7

    5. NM_001352304.2 → NP_001339233.1  la-related protein 4 isoform h

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variant 28, encodes isoform h.
      Source sequence(s)
      AC090058
      Consensus CDS
      CCDS86300.1
      UniProtKB/TrEMBL
      Q6P4E2, Q96J85
      Related
      ENSP00000430851.1, ENST00000518561.5
      Conserved Domains (2) summary
      cd08035
      Location:50 → 124
      LARP_4; La RNA-binding domain of La-related protein 4
      cd12707
      Location:129 → 205
      RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)

    6. NM_001352305.2 → NP_001339234.1  la-related protein 4 isoform i

      Status: VALIDATED

      Source sequence(s)
      AC090058
      Conserved Domains (2) summary
      cd08035
      Location:125 → 199
      LARP_4; La RNA-binding domain of La-related protein 4
      cd12707
      Location:204 → 280
      RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)

    7. NM_001352306.2 → NP_001339235.1  la-related protein 4 isoform j

      Status: VALIDATED

      Source sequence(s)
      AC090058
      Conserved Domains (2) summary
      cd08035
      Location:128 → 202
      LARP_4; La RNA-binding domain of La-related protein 4
      cl17169
      Location:207 → 265
      RRM_SF; RNA recognition motif (RRM) superfamily

    8. NM_001352307.2 → NP_001339236.1  la-related protein 4 isoform k

      Status: VALIDATED

      Source sequence(s)
      AC090058
      Conserved Domains (2) summary
      cd08035
      Location:120 → 194
      LARP_4; La RNA-binding domain of La-related protein 4
      cl17169
      Location:199 → 257
      RRM_SF; RNA recognition motif (RRM) superfamily

    9. NM_001352308.2 → NP_001339237.1  la-related protein 4 isoform l

      Status: VALIDATED

      Source sequence(s)
      AC090058
      Conserved Domains (2) summary
      cd08035
      Location:126 → 200
      LARP_4; La RNA-binding domain of La-related protein 4
      cl17169
      Location:205 → 275
      RRM_SF; RNA recognition motif (RRM) superfamily

    10. NM_001352309.2 → NP_001339238.1  la-related protein 4 isoform m

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13), as well as variants 14-18, encodes isoform m.
      Source sequence(s)
      AC090058
      Conserved Domains (2) summary
      cd08035
      Location:50 → 124
      LARP_4; La RNA-binding domain of La-related protein 4
      cd12707
      Location:129 → 205
      RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)

    11. NM_001352310.2 → NP_001339239.1  la-related protein 4 isoform m

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14), as well as variants 13 and 15-18, encodes isoform m.
      Source sequence(s)
      AC090058
      Conserved Domains (2) summary
      cd08035
      Location:50 → 124
      LARP_4; La RNA-binding domain of La-related protein 4
      cd12707
      Location:129 → 205
      RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)

    12. NM_001352311.2 → NP_001339240.1  la-related protein 4 isoform m

      Status: VALIDATED

      Description
      Transcript Variant: This variant (15), as well as variants 13, 14, and 16-18, encodes isoform m.
      Source sequence(s)
      AC090058
      Conserved Domains (2) summary
      cd08035
      Location:50 → 124
      LARP_4; La RNA-binding domain of La-related protein 4
      cd12707
      Location:129 → 205
      RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)

    13. NM_001352312.2 → NP_001339241.1  la-related protein 4 isoform m

      Status: VALIDATED

      Description
      Transcript Variant: This variant (16), as well as variants 13-15. 17, and 18, encodes isoform m.
      Source sequence(s)
      AC090058
      Conserved Domains (2) summary
      cd08035
      Location:50 → 124
      LARP_4; La RNA-binding domain of La-related protein 4
      cd12707
      Location:129 → 205
      RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)

    14. NM_001352313.2 → NP_001339242.1  la-related protein 4 isoform m

      Status: VALIDATED

      Description
      Transcript Variant: This variant (17), as well as variants 13-16 and 18, encodes isoform m.
      Source sequence(s)
      AC090058
      Conserved Domains (2) summary
      cd08035
      Location:50 → 124
      LARP_4; La RNA-binding domain of La-related protein 4
      cd12707
      Location:129 → 205
      RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)

    15. NM_001352314.2 → NP_001339243.1  la-related protein 4 isoform m

      Status: VALIDATED

      Description
      Transcript Variant: This variant (18), as well as variants 13-17, encodes isoform m.
      Source sequence(s)
      AC090058
      Conserved Domains (2) summary
      cd08035
      Location:50 → 124
      LARP_4; La RNA-binding domain of La-related protein 4
      cd12707
      Location:129 → 205
      RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)

    16. NM_001352315.2 → NP_001339244.1  la-related protein 4 isoform n

      Status: VALIDATED

      Source sequence(s)
      AC090058
      Conserved Domains (2) summary
      cd08035
      Location:119 → 193
      LARP_4; La RNA-binding domain of La-related protein 4
      cl17169
      Location:198 → 268
      RRM_SF; RNA recognition motif (RRM) superfamily

    17. NM_001352316.2 → NP_001339245.1  la-related protein 4 isoform o

      Status: VALIDATED

      Description
      Transcript Variant: This variant (20), as well as variant 21, encodes isoform o.
      Source sequence(s)
      AC090058
      Conserved Domains (2) summary
      cd08035
      Location:50 → 124
      LARP_4; La RNA-binding domain of La-related protein 4
      cl17169
      Location:129 → 199
      RRM_SF; RNA recognition motif (RRM) superfamily

    18. NM_001352317.2 → NP_001339246.1  la-related protein 4 isoform o

      Status: VALIDATED

      Description
      Transcript Variant: This variant (21), as well as variant 20, encodes isoform o.
      Source sequence(s)
      AC090058
      Conserved Domains (2) summary
      cd08035
      Location:50 → 124
      LARP_4; La RNA-binding domain of La-related protein 4
      cl17169
      Location:129 → 199
      RRM_SF; RNA recognition motif (RRM) superfamily

    19. NM_001352318.2 → NP_001339247.1  la-related protein 4 isoform p

      Status: VALIDATED

      Source sequence(s)
      AC090058
      Conserved Domains (2) summary
      cd08035
      Location:50 → 124
      LARP_4; La RNA-binding domain of La-related protein 4
      cd12707
      Location:129 → 205
      RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)

    20. NM_001352319.2 → NP_001339248.1  la-related protein 4 isoform q

      Status: VALIDATED

      Source sequence(s)
      AC090058
      Conserved Domains (2) summary
      cd08035
      Location:49 → 123
      LARP_4; La RNA-binding domain of La-related protein 4
      cl17169
      Location:128 → 198
      RRM_SF; RNA recognition motif (RRM) superfamily

    21. NM_001352320.2 → NP_001339249.1  la-related protein 4 isoform r

      Status: VALIDATED

      Source sequence(s)
      AC090058
      Conserved Domains (2) summary
      cd08035
      Location:50 → 124
      LARP_4; La RNA-binding domain of La-related protein 4
      cl17169
      Location:129 → 199
      RRM_SF; RNA recognition motif (RRM) superfamily

    22. NM_001352321.2 → NP_001339250.1  la-related protein 4 isoform s

      Status: VALIDATED

      Source sequence(s)
      AC090058
      Conserved Domains (2) summary
      cd08035
      Location:120 → 194
      LARP_4; La RNA-binding domain of La-related protein 4
      cd12707
      Location:199 → 275
      RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)

    23. NM_001352322.2 → NP_001339251.1  la-related protein 4 isoform t

      Status: VALIDATED

      Source sequence(s)
      AC090058
      Conserved Domains (2) summary
      cd08035
      Location:120 → 194
      LARP_4; La RNA-binding domain of La-related protein 4
      cl17169
      Location:199 → 269
      RRM_SF; RNA recognition motif (RRM) superfamily

    24. NM_001352323.2 → NP_001339252.1  la-related protein 4 isoform u

      Status: VALIDATED

      Source sequence(s)
      AC090058
      Conserved Domains (3) summary
      cd08035
      Location:120 → 194
      LARP_4; La RNA-binding domain of La-related protein 4
      cd12707
      Location:199 → 275
      RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)
      pfam14179
      Location:292 → 360
      YppG; YppG-like protein

    25. NM_001352324.2 → NP_001339253.1  la-related protein 4 isoform h

      Status: VALIDATED

      Description
      Transcript Variant: This variant (28), as well as variant 7, encodes isoform h.
      Source sequence(s)
      AC090058
      Consensus CDS
      CCDS86300.1
      UniProtKB/TrEMBL
      Q6P4E2, Q96J85
      Conserved Domains (2) summary
      cd08035
      Location:50 → 124
      LARP_4; La RNA-binding domain of La-related protein 4
      cd12707
      Location:129 → 205
      RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)

    26. NM_001352325.2 → NP_001339254.1  la-related protein 4 isoform v

      Status: VALIDATED

      Source sequence(s)
      AC090058
      UniProtKB/TrEMBL
      Q6P4E2
      Conserved Domains (3) summary
      cd08035
      Location:120 → 194
      LARP_4; La RNA-binding domain of La-related protein 4
      cd12707
      Location:199 → 275
      RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)
      pfam14179
      Location:292 → 360
      YppG; YppG-like protein

    27. NM_001352326.2 → NP_001339255.1  la-related protein 4 isoform w

      Status: VALIDATED

      Source sequence(s)
      AC090058
      UniProtKB/TrEMBL
      Q6P4E2
      Conserved Domains (2) summary
      cd08035
      Location:120 → 194
      LARP_4; La RNA-binding domain of La-related protein 4
      cl17169
      Location:199 → 269
      RRM_SF; RNA recognition motif (RRM) superfamily

    28. NM_052879.5 → NP_443111.4  la-related protein 4 isoform a

      See identical proteins and their annotated locations for NP_443111.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform a.
      Source sequence(s)
      AC090058
      Consensus CDS
      CCDS41782.1
      UniProtKB/Swiss-Prot
      A8K6T1, E9PDG5, G3XAA8, G5E976, Q5CZ97, Q6ZV14, Q71RC2, Q96NF9
      Related
      ENSP00000381490.2, ENST00000398473.7
      Conserved Domains (2) summary
      cd08035
      Location:120 → 194
      LARP_4; La RNA-binding domain of La-related protein 4
      cd12707
      Location:199 → 275
      RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)

    29. NM_199188.3 → NP_954658.2  la-related protein 4 isoform b

      See identical proteins and their annotated locations for NP_954658.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
      Source sequence(s)
      AC090058
      Consensus CDS
      CCDS44879.2
      UniProtKB/Swiss-Prot
      Q71RC2
      Related
      ENSP00000429077.1, ENST00000518444.5
      Conserved Domains (2) summary
      cd08035
      Location:119 → 193
      LARP_4; La RNA-binding domain of La-related protein 4
      cd12707
      Location:198 → 274
      RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)

    30. NM_199190.3 → NP_954660.1  la-related protein 4 isoform c

      See identical proteins and their annotated locations for NP_954660.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform c), compared to isoform a.
      Source sequence(s)
      AC090058
      Consensus CDS
      CCDS44880.1
      UniProtKB/Swiss-Prot
      Q71RC2
      Related
      ENSP00000340901.5, ENST00000347328.9
      Conserved Domains (2) summary
      cd08035
      Location:120 → 194
      LARP_4; La RNA-binding domain of La-related protein 4
      cl17169
      Location:199 → 269
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      50400885..50480004
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047428212.1 → XP_047284168.1  la-related protein 4 isoform X9

    2. XM_047428213.1 → XP_047284169.1  la-related protein 4 isoform X9

    3. XM_047428208.1 → XP_047284164.1  la-related protein 4 isoform X7

    4. XM_047428209.1 → XP_047284165.1  la-related protein 4 isoform X8

    5. XM_047428220.1 → XP_047284176.1  la-related protein 4 isoform X10

    6. XM_047428227.1 → XP_047284183.1  la-related protein 4 isoform X14

    7. XM_047428230.1 → XP_047284186.1  la-related protein 4 isoform X17

    8. XM_047428218.1 → XP_047284174.1  la-related protein 4 isoform X9

    9. XM_047428210.1 → XP_047284166.1  la-related protein 4 isoform X9

    10. XM_047428216.1 → XP_047284172.1  la-related protein 4 isoform X9

    11. XM_047428202.1 → XP_047284158.1  la-related protein 4 isoform X1

    12. XM_047428205.1 → XP_047284161.1  la-related protein 4 isoform X4

    13. XM_047428204.1 → XP_047284160.1  la-related protein 4 isoform X3

    14. XM_047428222.1 → XP_047284178.1  la-related protein 4 isoform X11

    15. XM_047428203.1 → XP_047284159.1  la-related protein 4 isoform X2

    16. XM_047428207.1 → XP_047284163.1  la-related protein 4 isoform X6

    17. XM_047428206.1 → XP_047284162.1  la-related protein 4 isoform X5

    18. XM_047428223.1 → XP_047284179.1  la-related protein 4 isoform X12

    19. XM_047428211.1 → XP_047284167.1  la-related protein 4 isoform X9

    20. XM_047428219.1 → XP_047284175.1  la-related protein 4 isoform X9

    21. XM_047428215.1 → XP_047284171.1  la-related protein 4 isoform X9

    22. XM_047428224.1 → XP_047284180.1  la-related protein 4 isoform X9

    23. XM_047428226.1 → XP_047284182.1  la-related protein 4 isoform X13

    24. XM_047428225.1 → XP_047284181.1  la-related protein 4 isoform X9

    25. XM_047428214.1 → XP_047284170.1  la-related protein 4 isoform X9

    26. XM_047428228.1 → XP_047284184.1  la-related protein 4 isoform X15

    27. XM_047428229.1 → XP_047284185.1  la-related protein 4 isoform X16

    28. XM_047428233.1 → XP_047284189.1  la-related protein 4 isoform X19

    29. XM_047428231.1 → XP_047284187.1  la-related protein 4 isoform X18

    30. XM_017018751.3 → XP_016874240.1  la-related protein 4 isoform X9

      UniProtKB/Swiss-Prot
      Q71RC2
      Conserved Domains (2) summary
      cd08035
      Location:50 → 124
      LARP_4; La RNA-binding domain of La-related protein 4
      cd12707
      Location:129 → 205
      RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)

    31. XM_047428217.1 → XP_047284173.1  la-related protein 4 isoform X9

    32. XM_017018753.3 → XP_016874242.1  la-related protein 4 isoform X9

      UniProtKB/Swiss-Prot
      Q71RC2
      Conserved Domains (2) summary
      cd08035
      Location:50 → 124
      LARP_4; La RNA-binding domain of La-related protein 4
      cd12707
      Location:129 → 205
      RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      50363921..50443087
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054370956.1 → XP_054226931.1  la-related protein 4 isoform X9

    2. XM_054370958.1 → XP_054226933.1  la-related protein 4 isoform X9

    3. XM_054370957.1 → XP_054226932.1  la-related protein 4 isoform X9

    4. XM_054370959.1 → XP_054226934.1  la-related protein 4 isoform X9

    5. XM_054370960.1 → XP_054226935.1  la-related protein 4 isoform X9

    6. XM_054370951.1 → XP_054226926.1  la-related protein 4 isoform X7

    7. XM_054370952.1 → XP_054226927.1  la-related protein 4 isoform X8

    8. XM_054370965.1 → XP_054226940.1  la-related protein 4 isoform X10

    9. XM_054370971.1 → XP_054226946.1  la-related protein 4 isoform X14

    10. XM_054370974.1 → XP_054226949.1  la-related protein 4 isoform X17

    11. XM_054370953.1 → XP_054226928.1  la-related protein 4 isoform X9

    12. XM_054370962.1 → XP_054226937.1  la-related protein 4 isoform X9

    13. XM_054370945.1 → XP_054226920.1  la-related protein 4 isoform X1

    14. XM_054370948.1 → XP_054226923.1  la-related protein 4 isoform X4

    15. XM_054370947.1 → XP_054226922.1  la-related protein 4 isoform X3

    16. XM_054370966.1 → XP_054226941.1  la-related protein 4 isoform X11

    17. XM_054370946.1 → XP_054226921.1  la-related protein 4 isoform X2

    18. XM_054370950.1 → XP_054226925.1  la-related protein 4 isoform X6

    19. XM_054370949.1 → XP_054226924.1  la-related protein 4 isoform X5

    20. XM_054370967.1 → XP_054226942.1  la-related protein 4 isoform X12

    21. XM_054370954.1 → XP_054226929.1  la-related protein 4 isoform X9

    22. XM_054370964.1 → XP_054226939.1  la-related protein 4 isoform X9

    23. XM_054370968.1 → XP_054226943.1  la-related protein 4 isoform X9

    24. XM_054370970.1 → XP_054226945.1  la-related protein 4 isoform X13

    25. XM_054370969.1 → XP_054226944.1  la-related protein 4 isoform X9

    26. XM_054370961.1 → XP_054226936.1  la-related protein 4 isoform X9

    27. XM_054370972.1 → XP_054226947.1  la-related protein 4 isoform X15

    28. XM_054370973.1 → XP_054226948.1  la-related protein 4 isoform X16

    29. XM_054370976.1 → XP_054226951.1  la-related protein 4 isoform X19

    30. XM_054370975.1 → XP_054226950.1  la-related protein 4 isoform X18

    31. XM_054370955.1 → XP_054226930.1  la-related protein 4 isoform X9

    32. XM_054370963.1 → XP_054226938.1  la-related protein 4 isoform X9

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q71RC2.3 GenPept UniProtKB/Swiss-Prot:Q71RC2

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