Taar1 trace amine-associated receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Taar1provided by MGI
Official Full Name: trace amine-associated receptor 1provided by MGI
Primary source: MGI:MGI:2148258
See related: Ensembl:ENSMUSG00000056379 AllianceGenome:MGI:2148258
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tar1; Trar1; taR-1
Summary: Enables trace-amine receptor activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; and phospholipase C-activating G protein-coupled receptor signaling pathway. Acts upstream of or within G protein-coupled receptor signaling pathway. Is active in plasma membrane. Used to study schizophrenia. Orthologous to human TAAR1 (trace amine associated receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human all
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Genomic context

Location:: 10 A4; 10 11.39 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (23796304..23797302)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (23920406..23921404)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dopamine D1 receptor in medial prefrontal cortex mediates the effects of TAAR1 activation on chronic stress-induced cognitive and social deficits.
Title: Dopamine D1 receptor in medial prefrontal cortex mediates the effects of TAAR1 activation on chronic stress-induced cognitive and social deficits.
TAAR1 in dentate gyrus is involved in chronic stress-induced impairments in hippocampal plasticity and cognitive function.
Title: TAAR1 in dentate gyrus is involved in chronic stress-induced impairments in hippocampal plasticity and cognitive function.
Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Title: Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
TAAR1 Regulates Purinergic-induced TNF Secretion from Peripheral, But Not CNS-resident, Macrophages.
Title: TAAR1 Regulates Purinergic-induced TNF Secretion from Peripheral, But Not CNS-resident, Macrophages.
Activation of trace amine-associated receptor 1 (TAAR1) transiently reduces alcohol drinking in socially housed mice.
Title: Activation of trace amine-associated receptor 1 (TAAR1) transiently reduces alcohol drinking in socially housed mice.
Enhanced Aggression, Reduced Self-Grooming Behavior and Altered 5-HT Regulation in the Frontal Cortex in Mice Lacking Trace Amine-Associated Receptor 1 (TAAR1).
Title: Enhanced Aggression, Reduced Self-Grooming Behavior and Altered 5-HT Regulation in the Frontal Cortex in Mice Lacking Trace Amine-Associated Receptor 1 (TAAR1).
A breeding strategy to identify modifiers of high genetic risk for methamphetamine intake.
Title: A breeding strategy to identify modifiers of high genetic risk for methamphetamine intake.
Role of trace amineassociated receptor 1 in the medial prefrontal cortex in chronic social stress-induced cognitive deficits in mice.
Title: Role of trace amine‑associated receptor 1 in the medial prefrontal cortex in chronic social stress-induced cognitive deficits in mice.
TAAR1-Dependent and -Independent Actions of Tyramine in Interaction With Glutamate Underlie Central Effects of Monoamine Oxidase Inhibition.
Title: TAAR1-Dependent and -Independent Actions of Tyramine in Interaction With Glutamate Underlie Central Effects of Monoamine Oxidase Inhibition.
Differential genetic risk for methamphetamine intake confers differential sensitivity to the temperature-altering effects of other addictive drugs.
Title: Differential genetic risk for methamphetamine intake confers differential sensitivity to the temperature-altering effects of other addictive drugs.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Spontaneous (1) 1 citation
Targeted (5) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:488210

Taar1 (e-PCR), detects polymorphism
- UniSTS:516726

NoName (e-PCR)
- UniSTS:494010

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled amine receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables trace-amine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables trace-amine receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables trace-amine receptor activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within adenylate cyclase-activating dopamine receptor signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IC Inferred by Curator more info	PubMed
located_in membrane	RCA inferred from Reviewed Computational Analysis more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: trace amine-associated receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053205.1 → NP_444435.1 trace amine-associated receptor 1

See identical proteins and their annotated locations for NP_444435.1

Status: PROVISIONAL

Source sequence(s)

AF380187

Consensus CDS

CCDS23735.1

UniProtKB/Swiss-Prot

Q05A85, Q923Y8

Related

ENSMUSP00000049527.5, ENSMUST00000051532.5

Conserved Domains (2) summary

pfam00001
Location:39 → 301

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:37 → 316

7tm_4; Olfactory receptor