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    Mpi mannose phosphate isomerase [ Mus musculus (house mouse) ]

    Gene ID: 110119, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mpiprovided by MGI
    Official Full Name
    mannose phosphate isomeraseprovided by MGI
    Primary source
    MGI:MGI:97075
    See related
    Ensembl:ENSMUSG00000032306 AllianceGenome:MGI:97075
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mpi1; Mpi-1; 1110002E17Rik
    Summary
    Enables mannose-6-phosphate isomerase activity. Involved in GDP-mannose biosynthetic process from glucose. Acts upstream of or within mannose to fructose-6-phosphate catabolic process. Is active in cytosol. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder and congenital disorder of glycosylation Ib. Orthologous to human MPI (mannose phosphate isomerase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 49.7), large intestine adult (RPKM 32.3) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mpi in Genome Data Viewer
    Location:
    9 B; 9 31.05 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (57448744..57460095, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (57544260..57552812, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24239 Neighboring gene ribonuclease P/MRP 25 subunit Neighboring gene STARR-positive B cell enhancer ABC_E11408 Neighboring gene cytochrome c oxidase subunit 5A Neighboring gene family with sequence similarity 219, member B Neighboring gene STARR-positive B cell enhancer ABC_E3834 Neighboring gene STARR-positive B cell enhancer ABC_E3835 Neighboring gene secretory carrier membrane protein 2 Neighboring gene unc-51-like kinase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PMI-controlled mannose metabolism and glycosylation determines tissue tolerance and virus fitness. Liang R, et al. Nat Commun, 2024 Mar 8. PMID 38459021, Free PMC Article
    2. The relative contribution of mannose salvage pathways to glycosylation in PMI-deficient mouse embryonic fibroblast cells. Fujita N, et al. FEBS J, 2008 Feb. PMID 18215164
    3. Metabolically programmed quality control system for dolichol-linked oligosaccharides. Harada Y, et al. Proc Natl Acad Sci U S A, 2013 Nov 26. PMID 24218558, Free PMC Article
    4. [Presence of a male sterility factor, Hst-2, segregating in interspecies crosses. M. musculus L. x M. spretus Lastaste and linked to Mod-1, and Mpi-1 on chromosome 9]. Bonhomme F, et al. C R Seances Acad Sci III, 1982 Apr 19. PMID 6812867
    5. Molecular cloning, gene organization, and expression of mouse Mpi encoding phosphomannose isomerase. Davis JA, et al. Glycobiology, 2002 Jul. PMID 12122025

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PMI-controlled mannose metabolism and glycosylation determines tissue tolerance and virus fitness.
      Title: PMI-controlled mannose metabolism and glycosylation determines tissue tolerance and virus fitness.
    2. Data indicate that reduced phosphomannose isomerase (MPI) alters mannose flux in hypomorphic mice.
      Title: Mannose supplements induce embryonic lethality and blindness in phosphomannose isomerase hypomorphic mice.
    3. Phosphomannose isomerase activity and mRNA levels increased at 1 month, and the values in the ileum were lower than in jejunum.
      Title: Ontogeny of D-mannose transport and metabolism in rat small intestine.
    4. Data conclude that PMI-null cells can salvage mannose from both endogenous and external glycoconjugates via lysosomal and nonlysosomal degradation pathways.
      Title: The relative contribution of mannose salvage pathways to glycosylation in PMI-deficient mouse embryonic fibroblast cells.
    5. Results suggest that mannose toxicity in phosphomannose isomerase(-/-) embryos is caused by mannose-6-P accumulation, which inhibits glucose metabolism and depletes intracellular ATP.
      Title: Ablation of mouse phosphomannose isomerase (Mpi) causes mannose 6-phosphate accumulation, toxicity, and embryonic lethality.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mannose-6-phosphate isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mannose-6-phosphate isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mannose-6-phosphate isomerase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables mannose-6-phosphate isomerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GDP-mannose biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GDP-mannose biosynthetic process from fructose-6-phosphate IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GDP-mannose biosynthetic process from glucose IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within glycolytic process from mannose through fructose-6-phosphate IC
    Inferred by Curator
    more info
    		 PubMed 
    acts_upstream_of_or_within mannose to fructose-6-phosphate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mannose to fructose-6-phosphate catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mannose to fructose-6-phosphate catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mannose-6-phosphate isomerase
    Names
    PMI
    mannose phosphate isomerase 1
    phosphohexomutase
    phosphomannose isomerase
    NP_080113.1
    XP_006510834.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025837.2 → NP_080113.1  mannose-6-phosphate isomerase

      See identical proteins and their annotated locations for NP_080113.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the protein-coding transcript.
      Source sequence(s)
      AK132777
      Consensus CDS
      CCDS40650.1
      UniProtKB/Swiss-Prot
      Q924M7
      UniProtKB/TrEMBL
      Q3V100, Q921Z9
      Related
      ENSMUSP00000034856.9, ENSMUST00000034856.15
      Conserved Domains (2) summary
      COG1482
      Location:9 → 403
      ManA; Mannose-6-phosphate isomerase, class I [Carbohydrate transport and metabolism]
      pfam01238
      Location:6 → 381
      PMI_typeI; Phosphomannose isomerase type I

    RNA

    1. NR_151692.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC164548

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      57448744..57460095 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510771.4 → XP_006510834.1  mannose-6-phosphate isomerase isoform X1

      Conserved Domains (1) summary
      cl21464
      Location:3 → 192
      cupin_like; Conserved domain found in cupin and related proteins

    RNA

    1. XR_001778789.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q924M7.1 GenPept UniProtKB/Swiss-Prot:Q924M7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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