Rnf169 ring finger protein 169 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rnf169provided by MGI
Official Full Name: ring finger protein 169provided by MGI
Primary source: MGI:MGI:1920257
See related: Ensembl:ENSMUSG00000058761 AllianceGenome:MGI:1920257
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2900057K09Rik
Summary: Predicted to enable modification-dependent protein binding activity; nucleosome binding activity; and ubiquitin-protein transferase activity. Predicted to be involved in double-strand break repair via homologous recombination and negative regulation of double-strand break repair. Predicted to be located in cytosol; nuclear body; and nucleolus. Predicted to be active in nucleus and site of double-strand break. Is expressed in nervous system and retina. Orthologous to human RNF169 (ring finger protein 169). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 1.9), CNS E11.5 (RPKM 1.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E2; 7 54.22 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (99569461..99630537, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (99920254..99981330, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:494397

NoName (e-PCR)
- UniSTS:493126

RH135181 (e-PCR)
- UniSTS:218458

RH125893 (e-PCR)
- UniSTS:142709

RH124875 (e-PCR)
- UniSTS:161697

RH80644 (e-PCR)
- UniSTS:92322

RH124899 (e-PCR)
- UniSTS:161721

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables K63-linked polyubiquitin modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables K63-linked polyubiquitin modification-dependent protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleosome binding	ISO Inferred from Sequence Orthology more info
enables nucleosome binding	ISS Inferred from Sequence or Structural Similarity more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-modified histone reader activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-modified histone reader activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair via homologous recombination	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of double-strand break repair	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of double-strand break repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in site of double-strand break	IBA Inferred from Biological aspect of Ancestor more info
located_in site of double-strand break	ISO Inferred from Sequence Orthology more info
located_in site of double-strand break	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase RNF169

Names: RING-type E3 ubiquitin transferase RNF169

NP_780597.2

EC 2.3.2.27

XP_006507248.1

EC 2.3.2.27

XP_006507250.1

EC 2.3.2.27

XP_006507251.1

EC 2.3.2.27

XP_030097842.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175388.3 → NP_780597.2 E3 ubiquitin-protein ligase RNF169

See identical proteins and their annotated locations for NP_780597.2

Status: PROVISIONAL

Source sequence(s)

AC113298

Consensus CDS

CCDS52322.1

UniProtKB/Swiss-Prot

E9Q7F2, Q69Z47

Related

ENSMUSP00000079631.4, ENSMUST00000080817.6

Conserved Domains (1) summary

pfam05142
Location:76 → 143

DUF702; Domain of unknown function (DUF702)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

99569461..99630537 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006507185.4 → XP_006507248.1 E3 ubiquitin-protein ligase RNF169 isoform X1

Conserved Domains (1) summary

cd16551
Location:90 → 127

RING-HC_RNF169; RING finger, HC subclass, found in RING finger protein 169 (RNF169) and similar proteins
XM_030241982.2 → XP_030097842.1 E3 ubiquitin-protein ligase RNF169 isoform X2
XM_006507187.5 → XP_006507250.1 E3 ubiquitin-protein ligase RNF169 isoform X2
XM_006507188.5 → XP_006507251.1 E3 ubiquitin-protein ligase RNF169 isoform X3

Conserved Domains (2) summary

cd00162
Location:91 → 126

RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]

cl17238
Location:90 → 127

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain