Ccdc88a coiled coil domain containing 88A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccdc88aprovided by MGI
Official Full Name: coiled coil domain containing 88Aprovided by MGI
Primary source: MGI:MGI:1925177
See related: Ensembl:ENSMUSG00000032740 AllianceGenome:MGI:1925177
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ape; Giv; Grdn; Hkrp1; Girdin; A430106J12Rik; C130096N06Rik; C330012F17Rik; D130005J21Rik
Summary: Enables microtubule binding activity; protein kinase B binding activity; and protein serine/threonine kinase activator activity. Involved in several processes, including TOR signaling; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and regulation of neuron projection development. Located in cell leading edge. Is expressed in several structures, including limb; lung; nervous system; sensory organ; and somite. Orthologous to human CCDC88A (coiled-coil domain containing 88A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E18 (RPKM 8.1), whole brain E14.5 (RPKM 7.1) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A3.3; 11 16.61 cM

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (29323521..29460808)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (29373405..29510808)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GIV/Girdin, a non-receptor modulator for Galphai/s, regulates spatiotemporal signaling during sperm capacitation and is required for male fertility.
Title: GIV/Girdin, a non-receptor modulator for Gαi/s, regulates spatiotemporal signaling during sperm capacitation and is required for male fertility.
TLR4 signaling and macrophage inflammatory responses are dampened by GIV/Girdin.
Title: TLR4 signaling and macrophage inflammatory responses are dampened by GIV/Girdin.
MiR-328-3p inhibits cell proliferation and metastasis in colorectal cancer by targeting Girdin and inhibiting the PI3K/Akt signaling pathway.
Title: MiR-328-3p inhibits cell proliferation and metastasis in colorectal cancer by targeting Girdin and inhibiting the PI3K/Akt signaling pathway.
Tyrosine Phosphorylation of an Actin-Binding Protein Girdin Specifically Marks Tuft Cells in Human and Mouse Gut
Title: Tyrosine Phosphorylation of an Actin-Binding Protein Girdin Specifically Marks Tuft Cells in Human and Mouse Gut.
This study aimed to prove the participation of mTORC2/Akt in F-actin assembling in early-stage cleavage of mouse fertilized eggs via the function of Girdin.
Title: F-actin rearrangement is regulated by mTORC2/Akt/Girdin in mouse fertilized eggs.
Akt-dependent Girdin phosphorylation regulates repair processes after acute myocardial infarction.
Title: Akt-dependent Girdin phosphorylation regulates repair processes after acute myocardial infarction.
GIV expression is up-regulated in liver after fibrotic injury and is required for hepatic stellate cells activation.Girdin is a central hub for profibrogenic signalling networks during liver fibrosis.
Title: GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis.
GIV and its substrate Galphai3 are recruited to active integrin complexes
Title: Integrins activate trimeric G proteins via the nonreceptor protein GIV/Girdin.
findings suggest a potential role of Girdin/kinesin-1 interaction in the regulation of neuroblast migration in the postnatal brain
Title: Potential involvement of kinesin-1 in the regulation of subcellular localization of Girdin.
Girdin phosphorylation at Y1798 was found at focal adhesions in NIH3T3 cells. Such phosphorylation was found where migration defects occurred in Girdin KO mice.
Title: Girdin is phosphorylated on tyrosine 1798 when associated with structures required for migration.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BB284152 (e-PCR)
- UniSTS:208648

AU016303 (e-PCR)
- UniSTS:208649

Ccdc88a (e-PCR), detects polymorphism
- UniSTS:506689

AI848406 (e-PCR)
- UniSTS:180167

NoName (e-PCR)
- UniSTS:236542

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G-protein alpha-subunit binding	ISO Inferred from Sequence Orthology more info
enables G-protein alpha-subunit binding	ISS Inferred from Sequence or Structural Similarity more info
enables G-protein gamma-subunit binding	ISO Inferred from Sequence Orthology more info
enables GDP-dissociation inhibitor activity	ISO Inferred from Sequence Orthology more info
enables GDP-dissociation inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables SH2 domain binding	ISO Inferred from Sequence Orthology more info
enables SH2 domain binding	ISS Inferred from Sequence or Structural Similarity more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin binding	ISS Inferred from Sequence or Structural Similarity more info
enables dynein light intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables epidermal growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables epidermal growth factor receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables insulin receptor binding	ISO Inferred from Sequence Orthology more info
enables insulin receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase B binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase B binding	ISO Inferred from Sequence Orthology more info
enables protein kinase C binding	ISO Inferred from Sequence Orthology more info
enables protein kinase C binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine/threonine kinase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables vascular endothelial growth factor receptor 2 binding	ISO Inferred from Sequence Orthology more info
enables vascular endothelial growth factor receptor 2 binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in TOR signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in activation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in cytoplasmic microtubule organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoskeleton-dependent intracellular transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoskeleton-dependent intracellular transport	IEA Inferred from Electronic Annotation more info
involved_in lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in lamellipodium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in maintenance of protein location in plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in maintenance of protein location in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in membrane organization	ISO Inferred from Sequence Orthology more info
involved_in membrane organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epidermal growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein localization to cilium	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in small GTPase-mediated signal transduction	ISO Inferred from Sequence Orthology more info
involved_in small GTPase-mediated signal transduction	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in COPI-coated Golgi to ER transport vesicle	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in cell leading edge	IDA Inferred from Direct Assay more info	PubMed
located_in centriole	IEA Inferred from Electronic Annotation more info
located_in centriole	ISO Inferred from Sequence Orthology more info
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: girdin

Names: Akt-phosphorylation enhancer; Hook-related protein 1; coiled-coil domain-containing protein 88A; g alpha-interacting vesicle-associated protein; girders of actin filament

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001363368.2 → NP_001350297.1 girdin isoform 1

Status: VALIDATED

Source sequence(s)

AL935054, BX284634

UniProtKB/TrEMBL

A0A6I8MX08

Related

ENSMUSP00000159356.2, ENSMUST00000239407.2

Conserved Domains (1) summary

cl25732
Location:477 → 1331

SMC_N; RecF/RecN/SMC N terminal domain
NM_001363369.2 → NP_001350298.1 girdin isoform 2

Status: VALIDATED

Source sequence(s)

AL935054, BX284634

Conserved Domains (1) summary

cl25732
Location:477 → 1331

SMC_N; RecF/RecN/SMC N terminal domain
NM_001433417.1 → NP_001420346.1 girdin isoform 4

Status: VALIDATED

Source sequence(s)

AL935054, BX284634
NM_176841.5 → NP_789811.2 girdin isoform 3

See identical proteins and their annotated locations for NP_789811.2

Status: VALIDATED

Source sequence(s)

AI530462, AK082029, AL935054, BX284634, CD803848, CN458498, CN532842, CO044538

Consensus CDS

CCDS24494.1

UniProtKB/Swiss-Prot

Q5SNZ0

Related

ENSMUSP00000048978.7, ENSMUST00000040182.13

Conserved Domains (6) summary

TIGR04523
Location:493 → 1205

Mplasa_alph_rch; helix-rich Mycoplasma protein

pfam05622
Location:18 → 584

HOOK; HOOK protein

pfam06156
Location:1061 → 1107

DUF972; Protein of unknown function (DUF972)

pfam09455
Location:488 → 638

Cas_DxTHG; CRISPR-associated (Cas) DxTHG family

cl09111
Location:766 → 859

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

cl19252
Location:825 → 943

MreC; rod shape-determining protein MreC

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

29323521..29460808

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006514455.5 → XP_006514518.1 girdin isoform X6

UniProtKB/Swiss-Prot

Q5M6X2, Q5M6X4, Q5M6X5, Q5SNZ0, Q5SNZ1, Q8C486, Q8CFU7

Conserved Domains (2) summary

COG1196
Location:477 → 1331

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam05622
Location:18 → 586

HOOK; HOOK protein
XM_036156225.1 → XP_036012118.1 girdin isoform X7

Conserved Domains (2) summary

COG1196
Location:477 → 1331

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd22229
Location:10 → 165

HkD_Girdin; Hook domain found in Girdin and similar proteins
XM_030245467.2 → XP_030101327.1 girdin isoform X8

Conserved Domains (2) summary

COG1196
Location:477 → 1331

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam05622
Location:18 → 586

HOOK; HOOK protein
XM_036156226.1 → XP_036012119.1 girdin isoform X9

Conserved Domains (2) summary

COG1196
Location:477 → 1308

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd22229
Location:10 → 165

HkD_Girdin; Hook domain found in Girdin and similar proteins
XM_017314219.3 → XP_017169708.1 girdin isoform X10

Conserved Domains (2) summary

COG1196
Location:477 → 1308

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam05622
Location:18 → 586

HOOK; HOOK protein
XM_006514452.5 → XP_006514515.1 girdin isoform X3

Conserved Domains (2) summary

COG1196
Location:477 → 1331

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam05622
Location:18 → 586

HOOK; HOOK protein
XM_036156223.1 → XP_036012116.1 girdin isoform X1

Conserved Domains (2) summary

COG1196
Location:477 → 1331

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd22229
Location:10 → 165

HkD_Girdin; Hook domain found in Girdin and similar proteins
XM_006514451.5 → XP_006514514.1 girdin isoform X2

Conserved Domains (2) summary

COG1196
Location:477 → 1331

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam05622
Location:18 → 586

HOOK; HOOK protein
XM_036156224.1 → XP_036012117.1 girdin isoform X4

Conserved Domains (2) summary

COG1196
Location:477 → 1331

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd22229
Location:10 → 165

HkD_Girdin; Hook domain found in Girdin and similar proteins
XM_006514454.5 → XP_006514517.1 girdin isoform X5

Conserved Domains (2) summary

COG1196
Location:477 → 1331

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam05622
Location:18 → 586

HOOK; HOOK protein
XM_036156227.1 → XP_036012120.1 girdin isoform X11

Conserved Domains (3) summary

COG1196
Location:491 → 1232

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam15921
Location:182 → 676

CCDC158; Coiled-coil domain-containing protein 158

cd22229
Location:10 → 165

HkD_Girdin; Hook domain found in Girdin and similar proteins