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    PGRMC1 progesterone receptor membrane component 1 [ Homo sapiens (human) ]

    Gene ID: 10857, updated on 3-Nov-2024

    Summary

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    Official Symbol
    PGRMC1provided by HGNC
    Official Full Name
    progesterone receptor membrane component 1provided by HGNC
    Primary source
    HGNC:HGNC:16090
    See related
    Ensembl:ENSG00000101856 MIM:300435; AllianceGenome:HGNC:16090
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IZA; MPR; Dap1; HPR6.6
    Summary
    This gene encodes a putative membrane-associated progesterone steroid receptor. The protein is expressed predominantly in the liver and kidney. [provided by RefSeq, Mar 2010]
    Expression
    Ubiquitous expression in liver (RPKM 180.6), kidney (RPKM 113.3) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PGRMC1 in Genome Data Viewer
    Location:
    Xq24
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (119236285..119244466)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (117614039..117622220)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (118370248..118378429)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 28 Neighboring gene NUDT19 pseudogene 6 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20953 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20954 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20955 Neighboring gene A-kinase anchoring protein 17B, pseudogene Neighboring gene Sharpr-MPRA regulatory region 13303 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20956 Neighboring gene long intergenic non-protein coding RNA 3098 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:118453061-118453562

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Expression of membrane and nuclear progesterone receptors in two human placental choriocarcinoma cell lines (JEG-3 and BeWo): Effects of syncytialization. Zachariades E, et al. Int J Mol Med, 2011 Jun. PMID 21455559
    2. Down-regulation of progesterone receptor membrane component 1 (PGRMC1) in peripheral nucleated blood cells associated with premature ovarian failure (POF) and polycystic ovary syndrome (PCOS). Schuster J, et al. Reprod Biol Endocrinol, 2010 Jun 10. PMID 20537145, Free PMC Article
    3. Progesterone receptor membrane component 1 as a potential prognostic biomarker for hepatocellular carcinoma. Tsai HW, et al. World J Gastroenterol, 2018 Mar 14. PMID 29563759, Free PMC Article
    4. Loss of β-Arrestins or six Gα proteins in HEK293 cells caused Warburg effect and prevented progesterone-induced rapid proteasomal degradation of progesterone receptor membrane component 1. Sabbir MG, et al. J Steroid Biochem Mol Biol, 2021 Nov. PMID 34506922
    5. Changes in PGRMC1, a potential progesterone receptor, in human myometrium during pregnancy and labour at term and preterm. Wu W, et al. Mol Hum Reprod, 2011 Apr. PMID 21131300

    See all (240) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PGRMC1 promotes NSCLC stemness phenotypes by disrupting TRIM56-mediated ubiquitination of AHR.
      Title: PGRMC1 promotes NSCLC stemness phenotypes by disrupting TRIM56-mediated ubiquitination of AHR.
    2. Progesterone-mediated remodeling of the maternal-fetal interface by a PGRMC1-dependent mechanism.
      Title: Progesterone-mediated remodeling of the maternal-fetal interface by a PGRMC1-dependent mechanism.
    3. Defining Requirements for Heme Binding in PGRMC1 and Identifying Key Elements that Influence Protein Dimerization.
      Title: Defining Requirements for Heme Binding in PGRMC1 and Identifying Key Elements that Influence Protein Dimerization.
    4. Progesterone-induced progesterone receptor membrane component 1 rise-to-decline changes are essential for decidualization.
      Title: Progesterone-induced progesterone receptor membrane component 1 rise-to-decline changes are essential for decidualization.
    5. Progesterone receptor membrane component 1 facilitates Ca[2+] signal amplification between endosomes and the endoplasmic reticulum.
      Title: Progesterone receptor membrane component 1 facilitates Ca(2+) signal amplification between endosomes and the endoplasmic reticulum.
    6. Downregulation of PGRMC1 accelerates differentiation and fusion of a human trophoblast cell line.
      Title: Downregulation of PGRMC1 accelerates differentiation and fusion of a human trophoblast cell line.
    7. Regulatory action of PGRMC1 on cyclic AMP-mediated COX2 expression in human endometrial cells.
      Title: Regulatory action of PGRMC1 on cyclic AMP-mediated COX2 expression in human endometrial cells.
    8. Progesterone Receptor Membrane Component 1 (PGRMC1) Modulates Tumour Progression, the Immune Microenvironment and the Response to Therapy in Glioblastoma.
      Title: Progesterone Receptor Membrane Component 1 (PGRMC1) Modulates Tumour Progression, the Immune Microenvironment and the Response to Therapy in Glioblastoma.
    9. Expression of PGRMC1 in patients with polycystic ovary syndrome and its molecular mechanism for regulating ovarian granulosa cell apoptosis and glucolipid metabolism.
      Title: Expression of PGRMC1 in patients with polycystic ovary syndrome and its molecular mechanism for regulating ovarian granulosa cell apoptosis and glucolipid metabolism.
    10. PGRMC1 promotes triple-negative breast cancer cell growth via suppressing ferroptosis.
      Title: PGRMC1 promotes triple-negative breast cancer cell growth via suppressing ferroptosis.
    Submit: New GeneRIF Correction See all GeneRIFs (99)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 is identified to have a physical interaction with progesterone receptor membrane component 1 (PGRMC1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with progesterone receptor membrane component 1 (PGRMC1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables amyloid-beta binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables heme binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heme binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables steroid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in heme biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of lipoprotein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in neuron projection ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in neuronal cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in smooth endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in specific granule membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    membrane-associated progesterone receptor component 1
    Names
    progesterone binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016756.1 RefSeqGene

      Range
      5038..13219
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001282621.2 → NP_001269550.1  membrane-associated progesterone receptor component 1 isoform 2

      See identical proteins and their annotated locations for NP_001269550.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
      Source sequence(s)
      AC004835, AK293618, HY166171, R49086
      Consensus CDS
      CCDS65313.1
      UniProtKB/Swiss-Prot
      O00264
      Related
      ENSP00000442821.1, ENST00000535419.2
      Conserved Domains (1) summary
      cl02041
      Location:74 → 107
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

    2. NM_006667.5 → NP_006658.1  membrane-associated progesterone receptor component 1 isoform 1

      See identical proteins and their annotated locations for NP_006658.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC004835, Y12711
      Consensus CDS
      CCDS14576.1
      UniProtKB/Swiss-Prot
      B7Z1L3, O00264, Q9UGJ9
      UniProtKB/TrEMBL
      Q6IB11
      Related
      ENSP00000217971.7, ENST00000217971.8
      Conserved Domains (1) summary
      pfam00173
      Location:74 → 137
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      119236285..119244466
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      117614039..117622220
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O00264.3 GenPept UniProtKB/Swiss-Prot:O00264

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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