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    Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 108078, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Olr1provided by MGI
    Official Full Name
    oxidized low density lipoprotein (lectin-like) receptor 1provided by MGI
    Primary source
    MGI:MGI:1261434
    See related
    Ensembl:ENSMUSG00000030162 AllianceGenome:MGI:1261434
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LOX-1; SR-EI; Scare1
    Summary
    Enables low-density lipoprotein particle receptor activity. Predicted to be involved in leukocyte cell-cell adhesion; lipoprotein metabolic process; and negative regulation of gene expression. Predicted to be located in nucleoplasm. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; extraembryonic component; genitourinary system; and immune system. Human ortholog(s) of this gene implicated in cerebral amyloid angiopathy; coronary artery disease; and myocardial infarction. Orthologous to human OLR1 (oxidized low density lipoprotein receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in placenta adult (RPKM 10.0), lung adult (RPKM 1.0) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Olr1 in Genome Data Viewer
    Location:
    6 F3; 6 63.35 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (129456113..129484312, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (129479150..129507350, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene C-type lectin domain family 12, member B Neighboring gene STARR-positive B cell enhancer mm9_chr6:129384284-129384585 Neighboring gene C-type lectin domain family 1, member a Neighboring gene STARR-seq mESC enhancer starr_17480 Neighboring gene predicted gene, 45969 Neighboring gene C-type lectin domain family 7, member a Neighboring gene transmembrane protein 52B Neighboring gene RIKEN cDNA 1700101I11 gene Neighboring gene STARR-positive B cell enhancer mm9_chr6:129481855-129482155 Neighboring gene GABA type A receptor associated protein like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Lectin-like oxidized low-density lipoprotein receptor-1 is required for the adipose tissue expression of proinflammatory cytokines in high-fat diet-induced obese mice. Takanabe-Mori R, et al. Biochem Biophys Res Commun, 2010 Jul 30. PMID 20599751
    2. Plasma L5 levels are elevated in ischemic stroke patients and enhance platelet aggregation. Shen MY, et al. Blood, 2016 Mar 10. PMID 26679863, Free PMC Article
    3. LOX‑1 is implicated in oxidized low‑density lipoprotein‑induced oxidative stress of macrophages in atherosclerosis. Yang HY, et al. Mol Med Rep, 2015 Oct. PMID 26165515
    4. LOX-1 plays an important role in ischemia-induced angiogenesis of limbs. Shiraki T, et al. PLoS One, 2014. PMID 25514797, Free PMC Article
    5. Lectin-like oxidized low-density lipoprotein receptor-1 regulates autophagy and Toll-like receptor 4 in the brain of hypertensive mice. Ding Z, et al. J Hypertens, 2015 Mar. PMID 25380158

    See all (115) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knockdown of LOX-1 ameliorates bone quality and generation of type H blood vessels in diabetic mice.
      Title: Knockdown of LOX-1 ameliorates bone quality and generation of type H blood vessels in diabetic mice.
    2. LOX-1 acts as an N[6]-methyladenosine-regulated receptor for Helicobacter pylori by binding to the bacterial catalase.
      Title: LOX-1 acts as an N(6)-methyladenosine-regulated receptor for Helicobacter pylori by binding to the bacterial catalase.
    3. Macrophage KLF15 prevents foam cell formation and atherosclerosis via transcriptional suppression of OLR-1.
      Title: Macrophage KLF15 prevents foam cell formation and atherosclerosis via transcriptional suppression of OLR-1.
    4. Overexpression of LOX-1 in hepatocytes protects vascular smooth muscle cells from phenotype transformation and wire injury induced carotid neoatherosclerosis through ALOX15.
      Title: Overexpression of LOX-1 in hepatocytes protects vascular smooth muscle cells from phenotype transformation and wire injury induced carotid neoatherosclerosis through ALOX15.
    5. Lectin-like oxidized low-density lipoprotein receptor 1 attenuates pneumonia-induced lung injury.
      Title: Lectin-like oxidized low-density lipoprotein receptor 1 attenuates pneumonia-induced lung injury.
    6. Nrf2 deficiency attenuates atherosclerosis by reducing LOX-1-mediated proliferation and migration of vascular smooth muscle cells.
      Title: Nrf2 deficiency attenuates atherosclerosis by reducing LOX-1-mediated proliferation and migration of vascular smooth muscle cells.
    7. Niclosamide downregulates LOX-1 expression in mouse vascular smooth muscle cells and changes the composition of atherosclerotic plaques in ApoE(-/-) mice.
      Title: Niclosamide downregulates LOX-1 expression in mouse vascular smooth muscle cells and changes the composition of atherosclerotic plaques in ApoE(-/-) mice.
    8. LOX-1 Regulates Neutrophil Apoptosis and Fungal Load in A. Fumigatus Keratitis.
      Title: LOX-1 Regulates Neutrophil Apoptosis and Fungal Load in A. Fumigatus Keratitis.
    9. Critical role of oxidized LDL receptor-1 in intravascular thrombosis in a severe influenza mouse model.
      Title: Critical role of oxidized LDL receptor-1 in intravascular thrombosis in a severe influenza mouse model.
    10. Oxidized low-density lipoprotein stimulates dendritic cells maturation via LOX-1-mediated MAPK/NF-kappaB pathway.
      Title: Oxidized low-density lipoprotein stimulates dendritic cells maturation via LOX-1-mediated MAPK/NF-κB pathway.
    Submit: New GeneRIF Correction See all GeneRIFs (89)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables low-density lipoprotein particle receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables low-density lipoprotein particle receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in leukocyte cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in leukocyte cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipoprotein metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipoprotein metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extrinsic component of plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    oxidized low-density lipoprotein receptor 1
    Names
    lectin-like oxLDL receptor 1
    lectin-like oxidized LDL receptor 1
    lectin-type oxidized LDL receptor 1
    ox-LDL receptor 1
    oxidised low density lipoprotein (lectin-like) receptor 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301094.1 → NP_001288023.1  oxidized low-density lipoprotein receptor 1 isoform 3

      See identical proteins and their annotated locations for NP_001288023.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks exons in the coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
      Source sequence(s)
      AC161602, BX513847
      Consensus CDS
      CCDS80620.1
      UniProtKB/TrEMBL
      G4WK10
      Related
      ENSMUSP00000138588.2, ENSMUST00000182784.4
      Conserved Domains (1) summary
      cd03593
      Location:61 → 182
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    2. NM_001301096.1 → NP_001288025.1  oxidized low-density lipoprotein receptor 1 isoform 2

      See identical proteins and their annotated locations for NP_001288025.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks exons in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AC161602, BX513847
      Consensus CDS
      CCDS80619.1
      UniProtKB/TrEMBL
      G4WK09
      Related
      ENSMUSP00000138228.2, ENSMUST00000183258.8
      Conserved Domains (1) summary
      cd03593
      Location:27 → 148
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    3. NM_138648.2 → NP_619589.2  oxidized low-density lipoprotein receptor 1 isoform 1

      See identical proteins and their annotated locations for NP_619589.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK160919, BX513847
      Consensus CDS
      CCDS20588.1
      UniProtKB/Swiss-Prot
      Q3U3M1, Q9EQ09
      Related
      ENSMUSP00000032265.7, ENSMUST00000032265.13
      Conserved Domains (4) summary
      cd03593
      Location:235 → 356
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
      pfam01442
      Location:71 → 229
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      pfam06273
      Location:156 → 214
      eIF-4B; Plant specific eukaryotic initiation factor 4B
      cl12057
      Location:96 → 175
      Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      129456113..129484312 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321299.3 → XP_017176788.1  oxidized low-density lipoprotein receptor 1 isoform X1

      Conserved Domains (2) summary
      cd03593
      Location:189 → 310
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
      TIGR02168
      Location:58 → 184
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. XM_017321300.1 → XP_017176789.1  oxidized low-density lipoprotein receptor 1 isoform X2

      Conserved Domains (2) summary
      cd03593
      Location:152 → 273
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
      TIGR02168
      Location:3 → 147
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RNA

    1. XR_001785081.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EQ09.2 GenPept UniProtKB/Swiss-Prot:Q9EQ09

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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