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    Osr2 odd-skipped related 2 [ Mus musculus (house mouse) ]

    Gene ID: 107587, updated on 2-Nov-2024

    Summary

    Official Symbol
    Osr2provided by MGI
    Official Full Name
    odd-skipped related 2provided by MGI
    Primary source
    MGI:MGI:1930813
    See related
    Ensembl:ENSMUSG00000022330 AllianceGenome:MGI:1930813
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Osr2A; Osr2B; 5430409I15Rik
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including embryonic limb morphogenesis; kidney development; and regulation of gene expression. Acts upstream of or within embryonic skeletal system morphogenesis and positive regulation of stem cell proliferation. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human OSR2 (odd-skipped related transciption factor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in ovary adult (RPKM 68.7), subcutaneous fat pad adult (RPKM 65.0) and 10 other tissues See more
    Orthologs
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    Genomic context

    See Osr2 in Genome Data Viewer
    Location:
    15 B3.1; 15 14.46 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (35296244..35303451)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (35296098..35303305)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 3 Neighboring gene STARR-seq mESC enhancer starr_38336 Neighboring gene predicted gene, 52204 Neighboring gene STARR-seq mESC enhancer starr_38337 Neighboring gene STARR-seq mESC enhancer starr_38338 Neighboring gene predicted gene, 52178 Neighboring gene predicted gene, 33497 Neighboring gene STARR-seq mESC enhancer starr_38340 Neighboring gene STARR-seq mESC enhancer starr_38341 Neighboring gene cDNA sequence BC048602 Neighboring gene predicted gene, 33584

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (6)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in bone morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chondrocyte differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in embryo development ending in birth or egg hatching IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in embryonic digit morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in embryonic forelimb morphogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in embryonic forelimb morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in embryonic hindlimb morphogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in embryonic hindlimb morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in embryonic skeletal joint development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in embryonic skeletal joint morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryonic skeletal limb joint morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within embryonic skeletal system morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in eyelid development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in head development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mesonephros development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in metanephros development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in middle ear morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in odontogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in osteoblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in pattern specification process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of bone mineralization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in pronephros development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in pronephros development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in roof of mouth development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in urogenital system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    protein odd-skipped-related 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368665.1NP_001355594.1  protein odd-skipped-related 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC116596
      Consensus CDS
      CCDS88748.1
      UniProtKB/Swiss-Prot
      Q8BPV6, Q91V54, Q91ZD1
      Related
      ENSMUSP00000154286.2, ENSMUST00000228152.2
      Conserved Domains (3) summary
      COG5048
      Location:251312
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:174194
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:186211
      zf-H2C2_2; Zinc-finger double domain
    2. NM_054049.3NP_473390.1  protein odd-skipped-related 2 isoform 2

      See identical proteins and their annotated locations for NP_473390.1

      Status: VALIDATED

      Source sequence(s)
      AC116596
      Consensus CDS
      CCDS27422.1
      UniProtKB/Swiss-Prot
      Q91ZD1
      Related
      ENSMUSP00000022952.5, ENSMUST00000022952.6
      Conserved Domains (2) summary
      sd00017
      Location:174194
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:214237
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      35296244..35303451
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004938784.1 RNA Sequence