Trip10 thyroid hormone receptor interactor 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trip10provided by MGI
Official Full Name: thyroid hormone receptor interactor 10provided by MGI
Primary source: MGI:MGI:2146901
See related: Ensembl:ENSMUSG00000019487 AllianceGenome:MGI:2146901
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cip4
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in epithelial to mesenchymal transition; negative regulation of cardiac muscle cell apoptotic process; and positive regulation of cell growth involved in cardiac muscle cell development. Predicted to be located in nucleoplasm. Is expressed in several structures, including clavicle; cranium; inner ear; submandibular gland primordium; and trigeminal ganglion. Orthologous to human TRIP10 (thyroid hormone receptor interactor 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 19.3), heart adult (RPKM 17.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 D; 17 29.74 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (57540227..57570712)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (57233220..57263697)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CIP4 silencing can efficiently alleviate Streptozotocin-induced pulmonary fibrosis in mice, perhaps through suppressing Wnt/GSK-3beta/beta-catenin signaling.
Title: Cdc42-interacting protein 4 silencing relieves pulmonary fibrosis in STZ-induced diabetic mice via the Wnt/GSK-3β/β-catenin pathway.
CIP4 coordinates with phospholipids and actin-associated proteins to localize to the protruding edge and produce actin ribs and veils.
Title: CIP4 coordinates with phospholipids and actin-associated proteins to localize to the protruding edge and produce actin ribs and veils.
CIP4 is a new component in the highly coordinated system of megakaryocytic membrane and cytoskeletal remodeling affecting platelet production.
Title: Loss of the F-BAR protein CIP4 reduces platelet production by impairing membrane-cytoskeleton remodeling.
Data suggest that down-regulation of CIP4 in osteosarcoma changes cell morphology (reduces actin; alters cytoskeleton), inhibits primary tumor growth, impairs invasiveness and migration of tumor cells, delays metastasis, and prolongs survival time.
Title: Inhibition of Cdc42-interacting protein 4 (CIP4) impairs osteosarcoma tumor progression.
In primary cortical neurons CIP4 is concentrated specifically at the tips of extending lamellipodia and filopodia, instead of endosomes as in other cell types.
Title: The F-BAR protein CIP4 inhibits neurite formation by producing lamellipodial protrusions.
Trip10 regulates cancer cell growth and death in a cancer type-specific manner. Differential DNA methylation of Trip10 can either promote cell survival or cell death in a cell type-dependent manner.
Title: Functional characterization of Trip10 in cancer cell growth and survival.
results demonstrate an important role for CIP4 in integrin-dependent T cell-dependent antibody responses and germinal center formation
Title: Cdc42 interacting protein 4 (CIP4) is essential for integrin-dependent T-cell trafficking.
The studies demonstrate a physiological role for CIP4 in endocytosis leading to a whole animal phenotype.
Title: The Cdc42-interacting protein-4 (CIP4) gene knock-out mouse reveals delayed and decreased endocytosis.
Insulin recruits the CIP4/Gapex-5 complex to the plasma membrane, thus reducing Rab31 activity and permitting Glut4 vesicles to translocate to the cell surface, where Glut4 docks and fuses to transport glucose into the cell.
Title: Gapex-5, a Rab31 guanine nucleotide exchange factor that regulates Glut4 trafficking in adipocytes.
Identification and genetic analysis of human and mouse activated Cdc42 interacting protein-4 isoforms (CIP4)
Title: Identification and genetic analysis of human and mouse activated Cdc42 interacting protein-4 isoforms.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D17Mit181 (e-PCR), detects polymorphism
- UniSTS:128000

AI646975 (e-PCR)
- UniSTS:181043

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cardiac muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth involved in cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in microtubule	TAS Traceable Author Statement more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in phagocytic cup	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cdc42-interacting protein 4

Names: Cdc42 interacting protein-4; TR-interacting protein 10; TRIP-10; thyroid receptor-interacting protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001242389.2 → NP_001229318.1 cdc42-interacting protein 4 isoform 1

See identical proteins and their annotated locations for NP_001229318.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

CT025692

Consensus CDS

CCDS89129.1

UniProtKB/Swiss-Prot

Q8BTR8, Q8CJ53, Q8R433, Q99LI0

Related

ENSMUSP00000153081.2, ENSMUST00000224152.2

Conserved Domains (3) summary

cd07653
Location:5 → 257

F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins

cd11628
Location:395 → 475

HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like

cd11911
Location:546 → 600

SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4
NM_001242390.2 → NP_001229319.1 cdc42-interacting protein 4 isoform 2

See identical proteins and their annotated locations for NP_001229319.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.

Source sequence(s)

CT025692

Consensus CDS

CCDS89130.1

UniProtKB/Swiss-Prot

Q8CJ53

Related

ENSMUSP00000153576.2, ENSMUST00000224885.2

Conserved Domains (3) summary

cd07653
Location:5 → 257

F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins

cd11628
Location:395 → 475

HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like

cd11911
Location:545 → 599

SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4
NM_001242391.2 → NP_001229320.1 cdc42-interacting protein 4 isoform 4

See identical proteins and their annotated locations for NP_001229320.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks an alternate in-frame exon and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (4) has the same N- and C-termini but lacks two alternate internal segments compared to isoform 1.

Source sequence(s)

CT025692

Consensus CDS

CCDS89131.1

UniProtKB/Swiss-Prot

Q8CJ53

Related

ENSMUSP00000019631.11, ENSMUST00000019631.11

Conserved Domains (3) summary

cd07653
Location:5 → 257

F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins

cd11628
Location:339 → 419

HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like

cd11911
Location:489 → 543

SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4
NM_001410293.1 → NP_001397222.1 cdc42-interacting protein 4 isoform 5

Status: VALIDATED

Source sequence(s)

CT025692
NM_001410294.1 → NP_001397223.1 cdc42-interacting protein 4 isoform 6

Status: VALIDATED

Source sequence(s)

CT025692
NM_001410295.1 → NP_001397224.1 cdc42-interacting protein 4 isoform 7

Status: VALIDATED

Source sequence(s)

CT025692
NM_001410296.1 → NP_001397225.1 cdc42-interacting protein 4 isoform 8

Status: VALIDATED

Source sequence(s)

CT025692
NM_001410297.1 → NP_001397226.1 cdc42-interacting protein 4 isoform 9

Status: VALIDATED

Source sequence(s)

CT025692
NM_001410298.1 → NP_001397227.1 cdc42-interacting protein 4 isoform 10

Status: VALIDATED

Source sequence(s)

CT025692
NM_001410299.1 → NP_001397228.1 cdc42-interacting protein 4 isoform 11

Status: VALIDATED

Source sequence(s)

CT025692
NM_001410300.1 → NP_001397229.1 cdc42-interacting protein 4 isoform 12

Status: VALIDATED

Source sequence(s)

CT025692
NM_001410301.1 → NP_001397230.1 cdc42-interacting protein 4 isoform 13

Status: VALIDATED

Source sequence(s)

CT025692
NM_001410302.1 → NP_001397231.1 cdc42-interacting protein 4 isoform 14

Status: VALIDATED

Source sequence(s)

CT025692
NM_001410303.1 → NP_001397232.1 cdc42-interacting protein 4 isoform 15

Status: VALIDATED

Source sequence(s)

CT025692
NM_134125.5 → NP_598886.1 cdc42-interacting protein 4 isoform 3

See identical proteins and their annotated locations for NP_598886.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

CT025692

Consensus CDS

CCDS28930.1

UniProtKB/Swiss-Prot

Q8CJ53

Related

ENSMUSP00000153467.2, ENSMUST00000224947.2

Conserved Domains (3) summary

cd07653
Location:5 → 257

F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins

cd11628
Location:339 → 419

HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like

cd11911
Location:490 → 544

SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

57540227..57570712

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006523401.5 → XP_006523464.1 cdc42-interacting protein 4 isoform X2

Conserved Domains (3) summary

cd11628
Location:360 → 440

HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like

cd11911
Location:511 → 565

SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4

cl12013
Location:31 → 222

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_006523400.4 → XP_006523463.1 cdc42-interacting protein 4 isoform X1

Conserved Domains (3) summary

cd07653
Location:5 → 238

F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins

cd11628
Location:376 → 456

HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like

cd11911
Location:527 → 581

SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4