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    Adcy3 adenylate cyclase 3 [ Mus musculus (house mouse) ]

    Gene ID: 104111, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Adcy3provided by MGI
    Official Full Name
    adenylate cyclase 3provided by MGI
    Primary source
    MGI:MGI:99675
    See related
    Ensembl:ENSMUSG00000020654 AllianceGenome:MGI:99675
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AC3; ACIII; mKIAA0511
    Summary
    Enables adenylate cyclase activity. Involved in several processes, including cAMP biosynthetic process; cellular response to forskolin; and olfactory learning. Acts upstream of or within sensory perception of smell. Located in ciliary membrane. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Used to study major depressive disorder. Orthologous to human ADCY3 (adenylate cyclase 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 11.6), ovary adult (RPKM 9.6) and 24 other tissues See more
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    Genomic context

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    See Adcy3 in Genome Data Viewer
    Location:
    12 A1.1; 12 1.99 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (4183397..4263525)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (4133116..4213525)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr12:3981365-3981666 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:3982390-3982573 Neighboring gene EFR3 homolog B Neighboring gene STARR-seq mESC enhancer starr_31433 Neighboring gene STARR-positive B cell enhancer mm9_chr12:4082834-4083134 Neighboring gene DnaJ heat shock protein family (Hsp40) member C27 Neighboring gene predicted gene, 53749 Neighboring gene STARR-seq mESC enhancer starr_31436 Neighboring gene centromere protein O Neighboring gene ubiquitin associated protein 2-like pseudogene Neighboring gene predicted gene, 29696 Neighboring gene peptidyl-tRNA hydrolase domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A gain-of-function mutation in adenylate cyclase 3 protects mice from diet-induced obesity. Pitman JL, et al. PLoS One, 2014. PMID 25329148, Free PMC Article
    2. Adenylyl cyclase type 3, a marker of primary cilia, is reduced in primary cell culture and in lumbar spinal cord in situ in G93A SOD1 mice. Ma X, et al. BMC Neurosci, 2011 Jul 18. PMID 21767396, Free PMC Article
    3. Deletion of Type 3 Adenylyl Cyclase Perturbs the Postnatal Maturation of Olfactory Sensory Neurons and Olfactory Cilium Ultrastructure in Mice. Zhang Z, et al. Front Cell Neurosci, 2017. PMID 28154525, Free PMC Article
    4. The type 3 adenylyl cyclase is required for novel object learning and extinction of contextual memory: role of cAMP signaling in primary cilia. Wang Z, et al. J Neurosci, 2011 Apr 13. PMID 21490195, Free PMC Article
    5. Maternal behavior is impaired in female mice lacking type 3 adenylyl cyclase. Wang Z, et al. Neuropsychopharmacology, 2011 Mar. PMID 21150908, Free PMC Article

    See all (135) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function.
      Title: Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function.
    2. Peripheral ablation of type III adenylyl cyclase induces hyperalgesia and eliminates KOR-mediated analgesia in mice.
      Title: Peripheral ablation of type III adenylyl cyclase induces hyperalgesia and eliminates KOR-mediated analgesia in mice.
    3. Adenylyl cyclase 3 deficiency results in dysfunction of blood-testis barrier during mouse spermiogenesis.
      Title: Adenylyl cyclase 3 deficiency results in dysfunction of blood-testis barrier during mouse spermiogenesis.
    4. Adenylyl cyclase 3 regulates osteocyte mechanotransduction and primary cilium.
      Title: Adenylyl cyclase 3 regulates osteocyte mechanotransduction and primary cilium.
    5. Type 3 adenylyl cyclase in the MOE is involved in learning and memory in mice.
      Title: Type 3 adenylyl cyclase in the MOE is involved in learning and memory in mice.
    6. Acid-Sensing Ion Channels Contribute to Type III Adenylyl Cyclase-Independent Acid Sensing of Mouse Olfactory Sensory Neurons.
      Title: Acid-Sensing Ion Channels Contribute to Type III Adenylyl Cyclase-Independent Acid Sensing of Mouse Olfactory Sensory Neurons.
    7. Data suggest that type 3 adenylyl cyclase is primarily expressed in the small to medium sized cell bodies and central terminals of CGRP-positive dorsal root ganglion neurons.
      Title: Expression pattern of type 3 adenylyl cyclase in rodent dorsal root ganglion and its primary afferent terminals.
    8. Cell apoptosis in the testicular tissues of AC3(-/-) mice increased significantly compared with that in wild-type (AC3(+/+)) mice. The expression of 693 genes was altered in the testicular tissues of AC3(-/-) mice, including 330 up-regulated and 363 down-regulated gene expression, helping to elucidate the mechanisms underlying the sterility in AC3(-/-) male mice.
      Title: Differentially expressed genes in the testicular tissues of adenylyl cyclase 3 knockout mice.
    9. AC3 may play a role in proximal olfactory signaling and play a role in the regulation of differentially expressed genes in mouse MOE.
      Title: Gene Expression Profiles of Main Olfactory Epithelium in Adenylyl Cyclase 3 Knockout Mice.
    10. genetic ablation of adenylate cyclase III has drastic, location-dependent effects on cilia architecture in the mouse nose
      Title: Genetic Ablation of Type III Adenylyl Cyclase Exerts Region-Specific Effects on Cilia Architecture in the Mouse Nose.
    Submit: New GeneRIF Correction See all GeneRIFs (25)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylate cyclase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables adenylate cyclase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables adenylate cyclase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables calcium- and calmodulin-responsive adenylate cyclase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in acrosome reaction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within activation of adenylate cyclase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cAMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cAMP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cAMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to forskolin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to forskolin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in olfactory learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sensory perception of smell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sensory perception of smell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in single fertilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in ciliary membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adenylate cyclase type 3
    Names
    AC-III
    ATP pyrophosphate-lyase 3
    adenylate cyclase type III
    adenylate cyclase, olfactive type
    adenylyl cyclase 3
    NP_001153008.1
    NP_001153009.1
    NP_001409715.1
    NP_612178.2
    XP_006514997.1
    XP_006514998.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159536.1 → NP_001153008.1  adenylate cyclase type 3 isoform 2

      See identical proteins and their annotated locations for NP_001153008.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This difference results in a shorter protein (isoform 2) compared to isoform 1. Variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AK122298, CF532558
      Consensus CDS
      CCDS49017.1
      UniProtKB/TrEMBL
      B8JK56, Q6PGC0
      Related
      ENSMUSP00000122073.2, ENSMUST00000124505.8
      Conserved Domains (3) summary
      smart00044
      Location:883 → 1101
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:914 → 1121
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:44 → 303
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    2. NM_001159537.1 → NP_001153009.1  adenylate cyclase type 3 isoform 2

      See identical proteins and their annotated locations for NP_001153009.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This difference results in a shorter protein (isoform 2) compared to isoform 1. Variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AK122298, CF532558
      Consensus CDS
      CCDS49017.1
      UniProtKB/TrEMBL
      B8JK56, Q6PGC0
      Related
      ENSMUSP00000115644.2, ENSMUST00000152065.8
      Conserved Domains (3) summary
      smart00044
      Location:883 → 1101
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:914 → 1121
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:44 → 303
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    3. NM_001422786.1 → NP_001409715.1  adenylate cyclase type 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      CT572999
      UniProtKB/Swiss-Prot
      B8JK57, Q8VHH7
      Related
      ENSMUST00000152792.8

    4. NM_138305.4 → NP_612178.2  adenylate cyclase type 3 isoform 1

      See identical proteins and their annotated locations for NP_612178.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      CT572999
      Consensus CDS
      CCDS25787.1
      UniProtKB/Swiss-Prot
      B8JK57, Q8VHH7
      UniProtKB/TrEMBL
      Q6PGC0
      Conserved Domains (2) summary
      pfam00211
      Location:915 → 1122
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:44 → 303
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      4183397..4263525
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514934.5 → XP_006514997.1  adenylate cyclase type 3 isoform X1

      See identical proteins and their annotated locations for XP_006514997.1

      UniProtKB/Swiss-Prot
      B8JK57, Q8VHH7
      UniProtKB/TrEMBL
      Q6PGC0
      Related
      ENSMUSP00000020984.8, ENSMUST00000020984.9
      Conserved Domains (2) summary
      pfam00211
      Location:915 → 1122
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:44 → 303
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    2. XM_006514935.5 → XP_006514998.1  adenylate cyclase type 3 isoform X1

      See identical proteins and their annotated locations for XP_006514998.1

      UniProtKB/Swiss-Prot
      B8JK57, Q8VHH7
      UniProtKB/TrEMBL
      Q6PGC0
      Related
      ENSMUSP00000115406.2, ENSMUST00000127756.8
      Conserved Domains (2) summary
      pfam00211
      Location:915 → 1122
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:44 → 303
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VHH7.2 GenPept UniProtKB/Swiss-Prot:Q8VHH7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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