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    Coa6 cytochrome c oxidase assembly factor 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 102556031, updated on 18-Sep-2024

    Summary

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    Symbol
    Coa6provided by RGD
    Full Name
    cytochrome c oxidase assembly factor 6provided by RGD
    Primary source
    RGD:7559315
    See related
    AllianceGenome:RGD:7559315
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable copper ion binding activity. Predicted to be involved in mitochondrial ATP synthesis coupled electron transport; plasma membrane ATP synthesis coupled electron transport; and respiratory chain complex IV assembly. Predicted to be located in mitochondrial intermembrane space and nucleoplasm. Predicted to be part of respiratory chain complex IV. Human ortholog(s) of this gene implicated in fatal infantile cardioencephalomyopathy due to cytochrome c oxidase deficiency 4. Orthologous to human COA6 (cytochrome c oxidase assembly factor 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 36.1), Heart (RPKM 33.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Coa6 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (71293066..71295668)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (54395746..54398348)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (59327328..59333706)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483661 Neighboring gene solute carrier family 35, member F3 Neighboring gene LIM domain-containing protein A-like Neighboring gene TAR (HIV-1) RNA binding protein 1 Neighboring gene uncharacterized LOC134483663 Neighboring gene uncharacterized LOC134483664

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. COA6 is a mitochondrial complex IV assembly factor critical for biogenesis of mtDNA-encoded COX2. Stroud DA, et al. Hum Mol Genet, 2015 Oct 1. PMID 26160915
    2. Mutations in COA6 cause cytochrome c oxidase deficiency and neonatal hypertrophic cardiomyopathy. Baertling F, et al. Hum Mutat, 2015 Jan. PMID 25339201
    3. Copper supplementation restores cytochrome c oxidase assembly defect in a mitochondrial disease model of COA6 deficiency. Ghosh A, et al. Hum Mol Genet, 2014 Jul 1. PMID 24549041, Free PMC Article
    4. Cooperation between COA6 and SCO2 in COX2 maturation during cytochrome c oxidase assembly links two mitochondrial cardiomyopathies. Pacheu-Grau D, et al. Cell Metab, 2015 Jun 2. PMID 25959673
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables copper ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial ATP synthesis coupled electron transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in plasma membrane ATP synthesis coupled electron transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in respiratory chain complex IV assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome c oxidase assembly factor 6
    Names
    cytochrome c oxidase assembly factor 6 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401093.1 → NP_001388022.1  cytochrome c oxidase assembly factor 6

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A8I5ZL79, A6KJ47

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      71293066..71295668
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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