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    Mettl21a methyltransferase 21A, HSPA lysine [ Rattus norvegicus (Norway rat) ]

    Gene ID: 102553119, updated on 10-Oct-2024

    Summary

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    Official Symbol
    Mettl21aprovided by RGD
    Official Full Name
    methyltransferase 21A, HSPA lysineprovided by RGD
    Primary source
    RGD:7651604
    See related
    EnsemblRapid:ENSRNOG00000014212 AllianceGenome:RGD:7651604
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fam119a; RGD1311824
    Summary
    Predicted to enable ATPase binding activity; Hsp70 protein binding activity; and protein-lysine N-methyltransferase activity. Predicted to be involved in peptidyl-lysine methylation. Predicted to be part of protein-containing complex. Predicted to be active in cytosol. Orthologous to human METTL21A (methyltransferase 21A, HSPA lysine). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 48.3), Thymus (RPKM 30.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mettl21a in Genome Data Viewer
    Location:
    9q32
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (73400223..73484677, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (65934253..65999964, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (71304138..71314015, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene small integral membrane protein 7-like Neighboring gene uncharacterized LOC134480377 Neighboring gene cAMP responsive element binding protein 1 Neighboring gene uncharacterized LOC134480378 Neighboring gene uncharacterized LOC120094695 Neighboring gene uncharacterized LOC134480380

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Lysine methylation of VCP by a member of a novel human protein methyltransferase family. Kernstock S, et al. Nat Commun, 2012. PMID 22948820
    2. Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation. Jakobsson ME, et al. J Biol Chem, 2013 Sep 27. PMID 23921388, Free PMC Article
    3. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. Cloutier P, et al. PLoS Genet, 2013. PMID 23349634, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-lysine N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-lysine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptidyl-lysine methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidyl-lysine methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in regulation of ATP-dependent activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein N-lysine methyltransferase METTL21A
    Names
    family with sequence similarity 119, member A
    methyltransferase like 21A
    protein N-lysine methyltransferase METTL21A-like
    NP_001386380.1
    XP_006245144.1
    XP_038940507.1
    XP_038940510.1
    XP_063122591.1
    XP_063122592.1
    XP_063122593.1
    XP_063122594.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399451.1 → NP_001386380.1  protein N-lysine methyltransferase METTL21A

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      D4A8Z5
      Related
      ENSRNOP00000019670.3, ENSRNOT00000019670.8
      Conserved Domains (1) summary
      pfam10294
      Location:25 → 190
      Methyltransf_16; Lysine methyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      73400223..73484677 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266523.1 → XP_063122593.1  protein N-lysine methyltransferase METTL21A isoform X4

    2. XM_039084582.2 → XP_038940510.1  protein N-lysine methyltransferase METTL21A isoform X4

      UniProtKB/TrEMBL
      A6IPI2
      Conserved Domains (1) summary
      cl17173
      Location:25 → 91
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    3. XM_063266522.1 → XP_063122592.1  protein N-lysine methyltransferase METTL21A isoform X3

    4. XM_063266521.1 → XP_063122591.1  protein N-lysine methyltransferase METTL21A isoform X2

    5. XM_006245082.5 → XP_006245144.1  protein N-lysine methyltransferase METTL21A isoform X1

      See identical proteins and their annotated locations for XP_006245144.1

      UniProtKB/TrEMBL
      D4A8Z5
      Conserved Domains (1) summary
      pfam10294
      Location:25 → 190
      Methyltransf_16; Lysine methyltransferase

    6. XM_039084579.2 → XP_038940507.1  protein N-lysine methyltransferase METTL21A isoform X1

      UniProtKB/TrEMBL
      D4A8Z5
      Conserved Domains (1) summary
      pfam10294
      Location:25 → 190
      Methyltransf_16; Lysine methyltransferase

    7. XM_063266524.1 → XP_063122594.1  protein N-lysine methyltransferase METTL21A isoform X5

    RNA

    1. XR_010054552.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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