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    NUTF2 nuclear transport factor 2 [ Homo sapiens (human) ]

    Gene ID: 10204, updated on 28-Oct-2024

    Summary

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    Official Symbol
    NUTF2provided by HGNC
    Official Full Name
    nuclear transport factor 2provided by HGNC
    Primary source
    HGNC:HGNC:13722
    See related
    Ensembl:ENSG00000102898 MIM:605813; AllianceGenome:HGNC:13722
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NTF2; PP15; NTF-2
    Summary
    This gene encodes a cytosolic factor that facilitates protein transport into the nucleus. The encoded protein is required for nuclear import of the small Ras-like GTPase, Ran which is involved in numerous cellular processes. This protein also interacts with the nuclear pore complex glycoprotein p62. [provided by RefSeq, Apr 2016]
    Expression
    Ubiquitous expression in placenta (RPKM 14.8), testis (RPKM 14.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NUTF2 in Genome Data Viewer
    Location:
    16q22.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (67846933..67872567)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (73642707..73668340)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67880836..67906470)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:67840207-67840826 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7626 Neighboring gene translin associated factor X interacting protein 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:67851021-67851203 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67859393-67860253 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10986 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10987 Neighboring gene centromere protein T Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10988 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7627 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67876439-67877185 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10990 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7628 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7629 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10991 Neighboring gene THAP domain containing 11 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:67907171-67907671 Neighboring gene enhancer of mRNA decapping 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10992 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67918365-67918874 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67918875-67919382 Neighboring gene neuritin 1 like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Isolation of cDNA coding for the placental protein 15 (PP15). Grundmann U, et al. Nucleic Acids Res, 1988 May 25. PMID 3380696, Free PMC Article
    2. [New placental protein (PP15) with immunosuppressive properties (author's transl)]. Bohn H, et al. Arch Gynecol, 1980. PMID 7458421
    3. Nuclear Transport Factor 2 (NTF2) suppresses WM983B metastatic melanoma by modifying cell migration, metastasis, and gene expression. Vuković LD, et al. Sci Rep, 2021 Dec 8. PMID 34880267, Free PMC Article
    4. DNA-Origami NanoTrap for Studying the Selective Barriers Formed by Phenylalanine-Glycine-Rich Nucleoporins. Shen Q, et al. J Am Chem Soc, 2021 Aug 11. PMID 34324340, Free PMC Article
    5. Nuclear-cytoplasmic trafficking of NTF2, the nuclear import receptor for the RanGTPase, is subjected to regulation. Chafe SC, et al. PLoS One, 2012. PMID 22880006, Free PMC Article

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DNA-Origami NanoTrap for Studying the Selective Barriers Formed by Phenylalanine-Glycine-Rich Nucleoporins.
      Title: DNA-Origami NanoTrap for Studying the Selective Barriers Formed by Phenylalanine-Glycine-Rich Nucleoporins.
    2. Nuclear Transport Factor 2 (NTF2) suppresses WM983B metastatic melanoma by modifying cell migration, metastasis, and gene expression.
      Title: Nuclear Transport Factor 2 (NTF2) suppresses WM983B metastatic melanoma by modifying cell migration, metastasis, and gene expression.
    3. These results showed that BLM enters the nucleus via the importin beta1, RanGDP and NTF2 dependent pathway, demonstrating for the first time the nuclear trafficking mechanism of a DNA helicase.
      Title: Characterization of the nuclear import pathway for BLM protein.
    4. Binding of Ran to NTF2 is required for NTF2 to inhibit nuclear expansion and import of large cargo molecules.
      Title: Nuclear size is sensitive to NTF2 protein levels in a manner dependent on Ran binding.
    5. Nucleocytoplasmic translocation of NTF2 is regulated in mammalian cells.
      Title: Nuclear-cytoplasmic trafficking of NTF2, the nuclear import receptor for the RanGTPase, is subjected to regulation.
    6. Data suggest actin accumulation in senescent cells is due to the failure of RanGTP restoration with ATP deficiency and NTF2 accumulation, resulting in decreased actin export via Exp6 inactivation.
      Title: Reduction of exportin 6 activity leads to actin accumulation via failure of RanGTP restoration and NTF2 sequestration in the nuclei of senescent cells.
    7. NTF2 is a potential mediator of retinal vasculature integrity.
      Title: Overexpression of nuclear transport factor 2 may protect against diabetic retinopathy.
    8. Results report that NTF2 and Ran control nuclear import of the filamentous actin capping protein CapG.
      Title: A new role for nuclear transport factor 2 and Ran: nuclear import of CapG.
    9. A nuclear pore binding site was studied on a mutated NTF2 protein.
      Title: Computational and biochemical identification of a nuclear pore complex binding site on the nuclear transport carrier NTF2.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog
    Common variants at 30 loci contribute to polygenic dyslipidemia.
    EBI GWAS Catalog
    Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    integrase gag-pol NTF2 is enriched at the nuclear envelope and interacts with NUP153, When added in excess to the import assay, NUP153C inhibited the nuclear import of IN. PubMed
    matrix gag NTF2 coordinates the activity of Ran by binding Ran-GDP into a complex with nucleoporin-docked karyopherins during nuclear import of HIV-1 Matrix PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of nuclear pore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein export from nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein localization to nuclear pore ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in nuclear inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore central transport channel IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nuclear transport factor 2
    Names
    placental protein 15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001322038.2 → NP_001308967.1  nuclear transport factor 2

      Status: REVIEWED

      Source sequence(s)
      AC040162
      Consensus CDS
      CCDS10848.1
      UniProtKB/Swiss-Prot
      B2R4G7, P13662, P61970, Q6IB67
      UniProtKB/TrEMBL
      H3BRV9
      Related
      ENSP00000515103.1, ENST00000700613.1
      Conserved Domains (1) summary
      cd00780
      Location:7 → 122
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

    2. NM_001322039.2 → NP_001308968.1  nuclear transport factor 2

      Status: REVIEWED

      Source sequence(s)
      AC040162, BP216441
      Consensus CDS
      CCDS10848.1
      UniProtKB/Swiss-Prot
      B2R4G7, P13662, P61970, Q6IB67
      UniProtKB/TrEMBL
      H3BRV9
      Related
      ENSP00000456428.1, ENST00000567105.5
      Conserved Domains (1) summary
      cd00780
      Location:7 → 122
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

    3. NM_001322040.2 → NP_001308969.1  nuclear transport factor 2

      Status: REVIEWED

      Source sequence(s)
      BX647782, HY123109, X07315
      Consensus CDS
      CCDS10848.1
      UniProtKB/Swiss-Prot
      B2R4G7, P13662, P61970, Q6IB67
      UniProtKB/TrEMBL
      H3BRV9
      Related
      ENSP00000457989.1, ENST00000569436.7
      Conserved Domains (1) summary
      cd00780
      Location:7 → 122
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

    4. NM_001322041.2 → NP_001308970.1  nuclear transport factor 2

      Status: REVIEWED

      Source sequence(s)
      AC040162, BX394845
      Consensus CDS
      CCDS10848.1
      UniProtKB/Swiss-Prot
      B2R4G7, P13662, P61970, Q6IB67
      UniProtKB/TrEMBL
      H3BRV9
      Related
      ENSP00000457022.1, ENST00000568396.2
      Conserved Domains (1) summary
      cd00780
      Location:7 → 122
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

    5. NM_005796.3 → NP_005787.1  nuclear transport factor 2

      See identical proteins and their annotated locations for NP_005787.1

      Status: REVIEWED

      Source sequence(s)
      BX647782, X07315
      Consensus CDS
      CCDS10848.1
      UniProtKB/Swiss-Prot
      B2R4G7, P13662, P61970, Q6IB67
      UniProtKB/TrEMBL
      H3BRV9
      Related
      ENSP00000219169.4, ENST00000219169.9
      Conserved Domains (1) summary
      cd00780
      Location:7 → 122
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      67846933..67872567
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      73642707..73668340
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61970.1 GenPept UniProtKB/Swiss-Prot:P61970

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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