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    TOB1 transducer of ERBB2, 1 [ Homo sapiens (human) ]

    Gene ID: 10140, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TOB1provided by HGNC
    Official Full Name
    transducer of ERBB2, 1provided by HGNC
    Primary source
    HGNC:HGNC:11979
    See related
    Ensembl:ENSG00000141232 MIM:605523; AllianceGenome:HGNC:11979
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TOB; TROB; APRO5; APRO6; PIG49; TROB1
    Summary
    This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
    Expression
    Ubiquitous expression in adrenal (RPKM 113.0), thyroid (RPKM 46.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TOB1 in Genome Data Viewer
    Location:
    17q21.33
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (50862223..50867978, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (51729361..51735122, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (48939584..48945339, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:48921781-48922306 Neighboring gene ribosomal protein L5 pseudogene 33 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12393 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8713 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8714 Neighboring gene TOB1 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:48962038-48962566 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:48962567-48963095 Neighboring gene uncharacterized LOC105371825 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:48986192-48987102 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:48987103-48988012 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12394 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8715 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:48995097-48996016 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8716 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8717 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:49012142-49012362 Neighboring gene uncharacterized LOC124904102 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:49021226-49022109 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:49022110-49022992

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TOB1 inhibits the gastric cancer progression by focal adhesion pathway and ERK pathway based on transcriptional and metabolic sequencing.
      Title: TOB1 inhibits the gastric cancer progression by focal adhesion pathway and ERK pathway based on transcriptional and metabolic sequencing.
    2. TOB1 modulates neutrophil phenotypes to influence gastric cancer progression and immunotherapy efficacy.
      Title: TOB1 modulates neutrophil phenotypes to influence gastric cancer progression and immunotherapy efficacy.
    3. Methylation Mediated Downregulation of TOB1-AS1 and TOB1 Correlates with Malignant Progression and Poor Prognosis of Esophageal Squamous Cell Carcinoma.
      Title: Methylation Mediated Downregulation of TOB1-AS1 and TOB1 Correlates with Malignant Progression and Poor Prognosis of Esophageal Squamous Cell Carcinoma.
    4. Involvement of TOB1 on autophagy in gastric cancer AGS cells via decreasing the activation of AKT/mTOR signaling pathway.
      Title: Involvement of TOB1 on autophagy in gastric cancer AGS cells via decreasing the activation of AKT/mTOR signaling pathway.
    5. Identification of miR253p as a tumor biomarker: Regulation of cellular functions via TOB1 in breast cancer.
      Title: Identification of miR‑25‑3p as a tumor biomarker: Regulation of cellular functions via TOB1 in breast cancer.
    6. TOB1 suppresses proliferation in K-Ras wild-type pancreatic cancer.
      Title: TOB1 suppresses proliferation in K-Ras wild-type pancreatic cancer.
    7. LncRNA WEE2-AS1 promotes proliferation and inhibits apoptosis in triple negative breast cancer cells via regulating miR-32-5p/TOB1 axis.
      Title: LncRNA WEE2-AS1 promotes proliferation and inhibits apoptosis in triple negative breast cancer cells via regulating miR-32-5p/TOB1 axis.
    8. The downregulation of DAL-1 and TOB1 expression is associated with shorter survival of gastric cancer patients and may be considered potential novel markers for predicting the outcomes of patients with gastric cancer
      Title: Decreased expression levels of DAL-1 and TOB1 are associated with clinicopathological features and poor prognosis in gastric cancer.
    9. TOB1 was found to be directly targeted by miR-371a-3p, in which TOB1 was down-regulated by miR-371a-3p in gastric cancer (GC). Most importantly, results showed that TOB1 plays a tumor-suppressive role in GC cells, and it is required for the miR-371a-3p's oncogenic activities in GC cells.
      Title: MicroRNA-371a-3p promotes progression of gastric cancer by targeting TOB1.
    10. Our findings provide important insights into a previously unrecognized oncogenic role of Tob1 in colon cancer and suggest that Tob1 is an adverse prognostic factor and therapeutic target for colon cancer.
      Title: High expression of Tob1 indicates poor survival outcome and promotes tumour progression via a Wnt positive feedback loop in colon cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (42)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC34446, MGC104792

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SMAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables receptor tyrosine kinase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of nuclear-transcribed mRNA poly(A) tail shortening IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of SMAD protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of CCR4-NOT complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein Tob1
    Names
    proliferation-inducing gene 49
    transducer of erbB-2 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243877.2 → NP_001230806.1  protein Tob1 isoform 1

      See identical proteins and their annotated locations for NP_001230806.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK313904, BC031406
      Consensus CDS
      CCDS11576.1
      UniProtKB/Swiss-Prot
      B2R9T0, D3DTY3, P50616, Q4KMQ0
      UniProtKB/TrEMBL
      Q2TU63
      Related
      ENSP00000268957.3, ENST00000268957.3
      Conserved Domains (1) summary
      smart00099
      Location:1 → 106
      btg1; tob/btg1 family

    2. NM_001243885.2 → NP_001230814.1  protein Tob1 isoform 2

      See identical proteins and their annotated locations for NP_001230814.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AA675891, AK313904, BC031406, DA039934
      UniProtKB/Swiss-Prot
      P50616

    3. NM_005749.4 → NP_005740.1  protein Tob1 isoform 1

      See identical proteins and their annotated locations for NP_005740.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      BC031406, BC098415, DA039934
      Consensus CDS
      CCDS11576.1
      UniProtKB/Swiss-Prot
      B2R9T0, D3DTY3, P50616, Q4KMQ0
      UniProtKB/TrEMBL
      Q2TU63
      Related
      ENSP00000427695.1, ENST00000499247.3
      Conserved Domains (1) summary
      smart00099
      Location:1 → 106
      btg1; tob/btg1 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      50862223..50867978 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      51729361..51735122 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50616.1 GenPept UniProtKB/Swiss-Prot:P50616

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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