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    DDC dopa decarboxylase [ Ovis aries (sheep) ]

    Gene ID: 101106765, updated on 8-Mar-2024

    Summary

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    Gene symbol
    DDC
    Gene description
    dopa decarboxylase
    See related
    EnsemblRapid:ENSOARG00020008635
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Ovis aries
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
    Orthologs
    human mouse all
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    Genomic context

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    See DDC in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 4 NC_056057.1 (6131062..6225649)

    Chromosome 4 - NC_056057.1Genomic Context describing neighboring genes Neighboring gene cordon-bleu WH2 repeat protein Neighboring gene uncharacterized LOC121819376 Neighboring gene growth factor receptor bound protein 10 Neighboring gene fidgetin like 1 Neighboring gene IKAROS family zinc finger 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_056057.1 Chromosome 4 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables aromatic-L-amino-acid decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in catecholamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in serotonin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aromatic-L-amino-acid decarboxylase
    Names
    dopa decarboxylase (aromatic L-amino acid decarboxylase)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Genomic

    1. NC_056057.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

      Range
      6131062..6225649
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_004007693.6 → XP_004007742.3  aromatic-L-amino-acid decarboxylase isoform X1

      UniProtKB/TrEMBL
      A0A836AH66
      Related
      ENSOARP00020011411.2, ENSOART00020013852.2
      Conserved Domains (1) summary
      cl18945
      Location:1 → 475
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

    2. XM_012176274.5 → XP_012031664.2  aromatic-L-amino-acid decarboxylase isoform X3

      UniProtKB/TrEMBL
      A0A836AH66
      Conserved Domains (1) summary
      pfam00282
      Location:35 → 321
      Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

    3. XM_042248334.2 → XP_042104268.1  aromatic-L-amino-acid decarboxylase isoform X2

      UniProtKB/TrEMBL
      A0A836AH66
      Related
      ENSOARP00020011699.2, ENSOART00020014184.2
      Conserved Domains (1) summary
      cl18945
      Location:1 → 437
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

    4. XM_027968422.3 → XP_027824223.2  aromatic-L-amino-acid decarboxylase isoform X4

      Conserved Domains (1) summary
      cl18945
      Location:1 → 380
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

    5. XM_004007692.6 → XP_004007741.3  aromatic-L-amino-acid decarboxylase isoform X1

      UniProtKB/TrEMBL
      A0A836AH66
      Related
      ENSOARP00020011725.2, ENSOART00020014217.2
      Conserved Domains (1) summary
      cl18945
      Location:1 → 475
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

    6. XM_042248335.2 → XP_042104269.1  aromatic-L-amino-acid decarboxylase isoform X3

      UniProtKB/TrEMBL
      A0A836AH66
      Related
      ENSOARP00020011553.1, ENSOART00020014001.2
      Conserved Domains (1) summary
      pfam00282
      Location:35 → 321
      Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain
    Nucleotide Protein Strain
    Heading Accession and Version

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