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    SMAD6 SMAD family member 6 [ Ovis aries (sheep) ]

    Gene ID: 101103068, updated on 8-Mar-2024

    Summary

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    Gene symbol
    SMAD6
    Gene description
    SMAD family member 6
    See related
    EnsemblRapid:ENSOARG00020008552
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Ovis aries
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
    Orthologs
    human mouse all
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    Genomic context

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    See SMAD6 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 7 NC_056060.1 (13513026..13590617)

    Chromosome 7 - NC_056060.1Genomic Context describing neighboring genes Neighboring gene zwilch kinetochore protein Neighboring gene lactase like Neighboring gene uncharacterized LOC121819944 Neighboring gene uncharacterized LOC132660117 Neighboring gene transfer RNA serine (anticodon GGA)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_056060.1 Chromosome 7 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables I-SMAD binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transcription regulator inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in SMAD protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of heteromeric SMAD protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mothers against decapentaplegic homolog 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Genomic

    1. NC_056060.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

      Range
      13513026..13590617
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_004010255.6 → XP_004010304.2  mothers against decapentaplegic homolog 6 isoform X1

      UniProtKB/TrEMBL
      A0A6P3EFH8, W5QA49
      Related
      ENSOARP00020010748.1, ENSOART00020013047.2
      Conserved Domains (2) summary
      cd10493
      Location:160 → 273
      MH1_SMAD_6; N-terminal Mad Homology 1 (MH1) domain in SMAD6
      cd10499
      Location:322 → 495
      MH2_SMAD_6; C-terminal Mad Homology 2 (MH2) domain in SMAD6

    2. XM_042252070.2 → XP_042108004.1  mothers against decapentaplegic homolog 6 isoform X2

      UniProtKB/TrEMBL
      W5QA49
      Related
      ENSOARP00020010778.2, ENSOART00020013081.2
      Conserved Domains (2) summary
      cd10493
      Location:160 → 273
      MH1_SMAD_6; N-terminal Mad Homology 1 (MH1) domain in SMAD6
      cd10499
      Location:277 → 450
      MH2_SMAD_6; C-terminal Mad Homology 2 (MH2) domain in SMAD6
    Nucleotide Protein Strain
    Heading Accession and Version

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