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    LAMA1 laminin subunit alpha 1 [ Ovis aries (sheep) ]

    Gene ID: 101102692, updated on 8-Mar-2024

    Summary

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    Gene symbol
    LAMA1
    Gene description
    laminin subunit alpha 1
    See related
    EnsemblRapid:ENSOARG00020017120
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Ovis aries
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
    Orthologs
    human mouse all
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    Genomic context

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    See LAMA1 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    63
    Annotation release Status Assembly Chr Location
    RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 23 NC_056076.1 (40436066..40560344, complement)

    Chromosome 23 - NC_056076.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105604473 Neighboring gene uncharacterized protein C4orf19-like Neighboring gene uncharacterized LOC121817770 Neighboring gene Rho GTPase activating protein 28 Neighboring gene uncharacterized LOC114110481 Neighboring gene leucine-rich repeat-containing protein 30-like Neighboring gene leucine-rich repeat-containing protein 30

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_056076.1 Chromosome 23 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables extracellular matrix structural constituent IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in blood vessel morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in camera-type eye development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basement membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    laminin subunit alpha-1
    Names
    laminin, alpha 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Genomic

    1. NC_056076.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

      Range
      40436066..40560344 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_042239145.2 → XP_042095079.1  laminin subunit alpha-1 isoform X2

      UniProtKB/TrEMBL
      A0A835ZJD4
      Conserved Domains (8) summary
      smart00136
      Location:20 → 272
      LamNT; Laminin N-terminal domain (domain VI)
      smart00180
      Location:1047 → 1090
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      smart00281
      Location:571 → 699
      LamB; Laminin B domain
      COG1842
      Location:1721 → 1985
      PspA; Phage shock protein A [Transcription, Signal transduction mechanisms]
      cd00055
      Location:905 → 952
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:2896 → 3049
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam06008
      Location:1578 → 1822
      Laminin_I; Laminin Domain I
      pfam06009
      Location:2015 → 2149
      Laminin_II; Laminin Domain II

    2. XM_027961074.3 → XP_027816875.2  laminin subunit alpha-1 isoform X1

      UniProtKB/TrEMBL
      A0A835ZJD4
      Related
      ENSOARP00020058145.1, ENSOART00020026362.2
      Conserved Domains (8) summary
      smart00136
      Location:20 → 272
      LamNT; Laminin N-terminal domain (domain VI)
      smart00180
      Location:1047 → 1090
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      smart00281
      Location:571 → 699
      LamB; Laminin B domain
      COG1842
      Location:1721 → 1985
      PspA; Phage shock protein A [Transcription, Signal transduction mechanisms]
      cd00055
      Location:905 → 952
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:2897 → 3050
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam06008
      Location:1578 → 1822
      Laminin_I; Laminin Domain I
      pfam06009
      Location:2015 → 2149
      Laminin_II; Laminin Domain II
    Nucleotide Protein Strain
    Heading Accession and Version

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