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    VEGFA vascular endothelial growth factor A [ Capra hircus (goat) ]

    Gene ID: 100860957, updated on 1-Aug-2024

    Summary

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    Gene symbol
    VEGFA
    Gene description
    vascular endothelial growth factor A
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Capra hircus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Capra
    Also known as
    VEGF; VEGFA165; VEGFA189
    Orthologs
    human mouse all
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    Genomic context

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    See VEGFA in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    102 current ASM170441v1 (GCF_001704415.1) 23 NC_030830.1 (31541137..31557206, complement)
    101 previous assembly CHIR_1.0 (GCF_000317765.1) 23 NC_022315.1 (16873123..16887239)

    Chromosome 23 - NC_030830.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 63B Neighboring gene mitochondrial ribosomal protein L14 Neighboring gene long intergenic non-protein coding RNA 3040 Neighboring gene D-tyrosyl-tRNA(Tyr) deacylase 1 pseudogene Neighboring gene mitochondrial ribosomal protein S18A Neighboring gene radial spoke head component 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chitosan and gelatin biopolymer supplemented with mesenchymal stem cells (Velgraft®) enhanced wound healing in goats (Capra hircus): Involvement of VEGF, TGF and CD31. Shukla A, et al. J Tissue Viability, 2021 Feb. PMID 33386237
    2. Characterization of Liaoning cashmere goat transcriptome: sequencing, de novo assembly, functional annotation and comparative analysis. Liu H, et al. PLoS One, 2013. PMID 24130835, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Chitosan and gelatin biopolymer supplemented with mesenchymal stem cells (Velgraft(R)) enhanced wound healing in goats (Capra hircus): Involvement of VEGF, TGF and CD31.
      Title: Chitosan and gelatin biopolymer supplemented with mesenchymal stem cells (Velgraft®) enhanced wound healing in goats (Capra hircus): Involvement of VEGF, TGF and CD31.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables chemoattractant activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables vascular endothelial growth factor receptor 1 binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables vascular endothelial growth factor receptor 2 binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in induction of positive chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of mast cell chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sprouting angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in vascular endothelial growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in vascular endothelial growth factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vascular endothelial growth factor A, long form; vascular endothelial growth factor A
    Names
    vascular endothelial growth factor 121
    vascular endothelila growth factor 165

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001287034.1 → NP_001273963.1  vascular endothelial growth factor A, long form isoform 1 precursor

      See identical proteins and their annotated locations for NP_001273963.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AJPT01201686, JO369225, JO455871
      UniProtKB/TrEMBL
      A0A024DAZ8, A0A8C2RUJ2
      Conserved Domains (2) summary
      smart00141
      Location:49 → 131
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam14554
      Location:166 → 214
      VEGF_C; VEGF heparin-binding domain

    2. NM_001287035.1 → NP_001273964.1  vascular endothelial growth factor A, long form isoform 2 precursor

      See identical proteins and their annotated locations for NP_001273964.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AJPT01201686, JO369226
      UniProtKB/TrEMBL
      F8UX49, K4P986
      Conserved Domains (2) summary
      smart00141
      Location:49 → 131
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam14554
      Location:133 → 190
      VEGF_C; VEGF heparin-binding domain

    RefSeqs of Annotated Genomes: Capra hircus Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ASM170441v1 Primary Assembly

    Genomic

    1. NC_030830.1 Reference ASM170441v1 Primary Assembly

      Range
      31541137..31557206 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_018038497.1 → XP_017893986.1  vascular endothelial growth factor A isoform X2

      UniProtKB/TrEMBL
      A0AAJ7JI51, G3LUM3

    2. XM_018038496.1 → XP_017893985.1  vascular endothelial growth factor A isoform X1

      UniProtKB/TrEMBL
      A0AAJ7NH51, F8UX49
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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