UBA5 ubiquitin like modifier activating enzyme 5 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: UBA5provided by VGNC
Official Full Name: ubiquitin like modifier activating enzyme 5provided by VGNC
Primary source: VGNC:VGNC:48039
See related: Ensembl:ENSCAFG00845029497
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: UBE1DC1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	23	NC_051827.1 (30159284..30172532)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	23	NC_006605.4 (29620276..29633519)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	23	NC_049244.1 (30160514..30173360)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	23	NC_049283.1 (29855266..29868510)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	23	NC_049764.1 (29912394..29925642)

Chromosome 23 - NC_051827.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables UFM1 activating enzyme activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in protein ufmylation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: ubiquitin-like modifier-activating enzyme 5

Names: ubiquitin-activating enzyme E1-domain containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051827.1 Reference ROS_Cfam_1.0

Range

30159284..30172532

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038432332.1 → XP_038288260.1 ubiquitin-like modifier-activating enzyme 5 isoform X2

UniProtKB/TrEMBL

A0A8C0REE0

Conserved Domains (1) summary

cl22428
Location:75 → 285

E1_enzyme_family; Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common ...
XM_038432331.1 → XP_038288259.1 ubiquitin-like modifier-activating enzyme 5 isoform X1

UniProtKB/TrEMBL

A0A8C0LZD3, A0A8C0REE0, A0A8C0Z441, A0A8I3Q0C2

Related

ENSCAFP00845040978.1, ENSCAFT00845052244.1

Conserved Domains (1) summary

cd00757
Location:75 → 320

ThiF_MoeB_HesA_family; ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD ...
XM_038432333.1 → XP_038288261.1 ubiquitin-like modifier-activating enzyme 5 isoform X3

Conserved Domains (1) summary

cd00757
Location:1 → 207

ThiF_MoeB_HesA_family; ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD ...

Alternate UMICH_Zoey_3.1

Genomic

NC_049283.1 Alternate UMICH_Zoey_3.1

Range

29855266..29868510

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038507627.1 → XP_038363555.1 ubiquitin-like modifier-activating enzyme 5 isoform X2

Conserved Domains (1) summary

cl22428
Location:75 → 285

E1_enzyme_family; Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common ...
XM_038507626.1 → XP_038363554.1 ubiquitin-like modifier-activating enzyme 5 isoform X1

Conserved Domains (1) summary

cd00757
Location:75 → 320

ThiF_MoeB_HesA_family; ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD ...
XM_038507628.1 → XP_038363556.1 ubiquitin-like modifier-activating enzyme 5 isoform X3

Conserved Domains (1) summary

cd00757
Location:1 → 207

ThiF_MoeB_HesA_family; ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD ...

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049764.1 Alternate UNSW_CanFamBas_1.0

Range

29912394..29925642

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038635060.1 → XP_038490988.1 ubiquitin-like modifier-activating enzyme 5 isoform X2

Conserved Domains (1) summary

cl22428
Location:75 → 285

E1_enzyme_family; Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common ...
XM_038635059.1 → XP_038490987.1 ubiquitin-like modifier-activating enzyme 5 isoform X1

Conserved Domains (1) summary

cd00757
Location:75 → 320

ThiF_MoeB_HesA_family; ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD ...
XM_038635062.1 → XP_038490990.1 ubiquitin-like modifier-activating enzyme 5 isoform X3

Conserved Domains (1) summary

cd00757
Location:1 → 207

ThiF_MoeB_HesA_family; ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD ...

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049244.1 Alternate UU_Cfam_GSD_1.0

Range

30160514..30173360

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038570865.1 → XP_038426793.1 ubiquitin-like modifier-activating enzyme 5 isoform X2

UniProtKB/TrEMBL

A0A8C0REE0

Conserved Domains (1) summary

cl22428
Location:75 → 285

E1_enzyme_family; Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common ...
XM_038570864.1 → XP_038426792.1 ubiquitin-like modifier-activating enzyme 5 isoform X1

UniProtKB/TrEMBL

A0A8C0LZD3, A0A8C0REE0, A0A8C0Z441, A0A8I3Q0C2

Conserved Domains (1) summary

cd00757
Location:75 → 320

ThiF_MoeB_HesA_family; ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD ...
XM_038570866.1 → XP_038426794.1 ubiquitin-like modifier-activating enzyme 5 isoform X3

Conserved Domains (1) summary

cd00757
Location:1 → 207

ThiF_MoeB_HesA_family; ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD ...

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006605.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

29620276..29633519

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038457145.1 → XP_038313073.1 ubiquitin-like modifier-activating enzyme 5 isoform X2

UniProtKB/TrEMBL

A0A8C0REE0

Conserved Domains (1) summary

cl22428
Location:75 → 285

E1_enzyme_family; Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common ...
XM_003639826.5 → XP_003639874.1 ubiquitin-like modifier-activating enzyme 5 isoform X1

UniProtKB/TrEMBL

A0A8C0LZD3, A0A8C0REE0, A0A8C0Z441, A0A8I3Q0C2

Conserved Domains (1) summary

cd00757
Location:75 → 320

ThiF_MoeB_HesA_family; ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD ...
XM_022408643.2 → XP_022264351.1 ubiquitin-like modifier-activating enzyme 5 isoform X3

Conserved Domains (1) summary

cd00757
Location:1 → 207

ThiF_MoeB_HesA_family; ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD ...