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    PKN1 protein kinase N1 [ Canis lupus familiaris (dog) ]

    Gene ID: 100856398, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PKN1provided by VGNC
    Official Full Name
    protein kinase N1provided by VGNC
    Primary source
    VGNC:VGNC:44611
    See related
    Ensembl:ENSCAFG00845022295
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See PKN1 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 20 NC_051824.1 (48679041..48702797, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 20 NC_006602.4 (48036227..48059971, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 20 NC_049241.1 (48559780..48583516, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 20 NC_049280.1 (47890581..47914314, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 20 NC_049761.1 (48316854..48340898, complement)

    Chromosome 20 - NC_051824.1Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member B1 Neighboring gene GIPC PDZ domain containing family member 1 Neighboring gene prostaglandin E receptor 1 Neighboring gene DExD-box helicase 39A Neighboring gene adhesion G protein-coupled receptor E5 Neighboring gene uncharacterized LOC111091367

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase N1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051824.1 Reference ROS_Cfam_1.0

      Range
      48679041..48702797 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038428377.1 → XP_038284305.1  serine/threonine-protein kinase N1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0K0N9, A0A8C0MMV2, A0A8I3PR84
      Related
      ENSCAFP00845031195.1, ENSCAFT00845039831.1
      Conserved Domains (5) summary
      cd08687
      Location:390 → 477
      C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
      cd11622
      Location:46 → 98
      HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
      cd11630
      Location:122 → 197
      HR1_PKN1_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1
      cd05589
      Location:617 → 941
      STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
      cl00087
      Location:206 → 279
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

    2. XM_038428375.1 → XP_038284303.1  serine/threonine-protein kinase N1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0MMV2, A0A8C0SYF2, A0A8I3PR84
      Conserved Domains (5) summary
      cd08687
      Location:402 → 489
      C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
      cd11622
      Location:58 → 110
      HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
      cd11630
      Location:134 → 209
      HR1_PKN1_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1
      cd05589
      Location:629 → 953
      STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
      cl00087
      Location:218 → 291
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

    3. XM_038428376.1 → XP_038284304.1  serine/threonine-protein kinase N1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0MM48, A0A8C0MMV2, A0A8C0QX22, A0A8I3PI86, A0A8I3PR84
      Related
      ENSCAFP00845030832.1, ENSCAFT00845039351.1
      Conserved Domains (5) summary
      cd08687
      Location:396 → 483
      C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
      cd11622
      Location:52 → 104
      HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
      cd11630
      Location:128 → 203
      HR1_PKN1_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1
      cd05589
      Location:623 → 947
      STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
      cl00087
      Location:212 → 285
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049280.1 Alternate UMICH_Zoey_3.1

      Range
      47890581..47914314 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038504020.1 → XP_038359948.1  serine/threonine-protein kinase N1 isoform X3

      Conserved Domains (5) summary
      cd08687
      Location:390 → 477
      C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
      cd11622
      Location:46 → 98
      HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
      cd11630
      Location:122 → 197
      HR1_PKN1_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1
      cd05589
      Location:617 → 941
      STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
      cl00087
      Location:206 → 279
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

    2. XM_038504018.1 → XP_038359946.1  serine/threonine-protein kinase N1 isoform X1

      Conserved Domains (5) summary
      cd08687
      Location:402 → 489
      C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
      cd11622
      Location:58 → 110
      HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
      cd11630
      Location:134 → 209
      HR1_PKN1_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1
      cd05589
      Location:629 → 953
      STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
      cl00087
      Location:218 → 291
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

    3. XM_038504019.1 → XP_038359947.1  serine/threonine-protein kinase N1 isoform X2

      Conserved Domains (5) summary
      cd08687
      Location:396 → 483
      C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
      cd11622
      Location:52 → 104
      HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
      cd11630
      Location:128 → 203
      HR1_PKN1_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1
      cd05589
      Location:623 → 947
      STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
      cl00087
      Location:212 → 285
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049761.1 Alternate UNSW_CanFamBas_1.0

      Range
      48316854..48340898 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038631188.1 → XP_038487116.1  serine/threonine-protein kinase N1 isoform X3

    2. XM_038631186.1 → XP_038487114.1  serine/threonine-protein kinase N1 isoform X1

    3. XM_038631187.1 → XP_038487115.1  serine/threonine-protein kinase N1 isoform X2

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049241.1 Alternate UU_Cfam_GSD_1.0

      Range
      48559780..48583516 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038567043.1 → XP_038422971.1  serine/threonine-protein kinase N1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0K0N9, A0A8C0MMV2, A0A8I3PR84
      Conserved Domains (5) summary
      cd08687
      Location:390 → 477
      C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
      cd11622
      Location:46 → 98
      HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
      cd11630
      Location:122 → 197
      HR1_PKN1_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1
      cd05589
      Location:617 → 941
      STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
      cl00087
      Location:206 → 279
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

    2. XM_038567041.1 → XP_038422969.1  serine/threonine-protein kinase N1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0MMV2, A0A8C0SYF2, A0A8I3PR84
      Conserved Domains (5) summary
      cd08687
      Location:402 → 489
      C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
      cd11622
      Location:58 → 110
      HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
      cd11630
      Location:134 → 209
      HR1_PKN1_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1
      cd05589
      Location:629 → 953
      STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
      cl00087
      Location:218 → 291
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

    3. XM_038567042.1 → XP_038422970.1  serine/threonine-protein kinase N1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0MM48, A0A8C0MMV2, A0A8C0QX22, A0A8I3PI86, A0A8I3PR84
      Conserved Domains (5) summary
      cd08687
      Location:396 → 483
      C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
      cd11622
      Location:52 → 104
      HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
      cd11630
      Location:128 → 203
      HR1_PKN1_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1
      cd05589
      Location:623 → 947
      STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
      cl00087
      Location:212 → 285
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006602.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      48036227..48059971 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003639779.3 → XP_003639827.1  serine/threonine-protein kinase N1 isoform X3

      UniProtKB/TrEMBL
      A0A8P0TGQ0
      Conserved Domains (6) summary
      cd08687
      Location:390 → 477
      C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
      cd11622
      Location:46 → 98
      HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
      cd11630
      Location:122 → 197
      HR1_PKN1_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1
      smart00220
      Location:617 → 875
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05589
      Location:617 → 941
      STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
      cl00087
      Location:206 → 279
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

    2. XM_005632788.4 → XP_005632845.1  serine/threonine-protein kinase N1 isoform X1

      UniProtKB/TrEMBL
      A0A8P0TGQ0
      Conserved Domains (6) summary
      cd08687
      Location:402 → 489
      C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
      cd11622
      Location:58 → 110
      HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
      cd11630
      Location:134 → 209
      HR1_PKN1_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1
      smart00220
      Location:629 → 887
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05589
      Location:629 → 953
      STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
      cl00087
      Location:218 → 291
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

    3. XM_003639780.4 → XP_003639828.1  serine/threonine-protein kinase N1 isoform X2

      UniProtKB/TrEMBL
      A0A8P0TA01, A0A8P0TGQ0
      Conserved Domains (6) summary
      cd08687
      Location:396 → 483
      C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
      cd11622
      Location:52 → 104
      HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
      cd11630
      Location:128 → 203
      HR1_PKN1_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1
      smart00220
      Location:623 → 881
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05589
      Location:623 → 947
      STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
      cl00087
      Location:212 → 285
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    Nucleotide Protein
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