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    DVL1 dishevelled segment polarity protein 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 100855811, updated on 17-Aug-2024

    Summary

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    Official Symbol
    DVL1provided by VGNC
    Official Full Name
    dishevelled segment polarity protein 1provided by VGNC
    Primary source
    VGNC:VGNC:53355
    See related
    Ensembl:ENSCAFG00845024543
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See DVL1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (56710022..56721601, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (56584127..56595703, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (56983289..56994870, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (56700763..56712335, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (56593044..56604611, complement)

    Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene ceramide-1-phosphate transfer protein Neighboring gene taste 1 receptor member 3 Neighboring gene uncharacterized LOC111095961 Neighboring gene matrix remodeling associated 8 Neighboring gene aurora kinase A interacting protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PAR1b promotes cell-cell adhesion and inhibits dishevelled-mediated transformation of Madin-Darby canine kidney cells. Elbert M, et al. Mol Biol Cell, 2006 Aug. PMID 16707567, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables frizzled binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    segment polarity protein dishevelled homolog DVL-1
    Names
    dishevelled, dsh homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051809.1 Reference ROS_Cfam_1.0

      Range
      56710022..56721601 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038666335.1 → XP_038522263.1  segment polarity protein dishevelled homolog DVL-1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0LSH9
      Conserved Domains (5) summary
      smart00021
      Location:1 → 85
      DAX; Domain present in Dishevelled and axin
      cd00992
      Location:249 → 336
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04438
      Location:392 → 474
      DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
      pfam02377
      Location:90 → 247
      Dishevelled; Dishevelled specific domain
      pfam12316
      Location:478 → 665
      Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

    2. XM_038666334.1 → XP_038522262.1  segment polarity protein dishevelled homolog DVL-1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0LSH9, A0A8I3PQU2
      Related
      ENSCAFP00845033969.1, ENSCAFT00845043350.1
      Conserved Domains (5) summary
      smart00021
      Location:1 → 85
      DAX; Domain present in Dishevelled and axin
      cd00992
      Location:249 → 336
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04438
      Location:417 → 499
      DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
      pfam02377
      Location:90 → 247
      Dishevelled; Dishevelled specific domain
      pfam12316
      Location:503 → 690
      Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

    3. XM_038666336.1 → XP_038522264.1  segment polarity protein dishevelled homolog DVL-1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0LSH9
      Conserved Domains (5) summary
      smart00021
      Location:1 → 85
      DAX; Domain present in Dishevelled and axin
      cd00992
      Location:249 → 336
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04438
      Location:417 → 499
      DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
      pfam02377
      Location:90 → 247
      Dishevelled; Dishevelled specific domain
      pfam12316
      Location:503 → 571
      Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049265.1 Alternate UMICH_Zoey_3.1

      Range
      56700763..56712335 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038476458.1 → XP_038332386.1  segment polarity protein dishevelled homolog DVL-1 isoform X2

    2. XM_038476457.1 → XP_038332385.1  segment polarity protein dishevelled homolog DVL-1 isoform X1

    3. XM_038476459.1 → XP_038332387.1  segment polarity protein dishevelled homolog DVL-1 isoform X3

      Conserved Domains (5) summary
      smart00021
      Location:1 → 85
      DAX; Domain present in Dishevelled and axin
      cd00992
      Location:249 → 336
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04438
      Location:417 → 499
      DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
      pfam02377
      Location:90 → 247
      Dishevelled; Dishevelled specific domain
      pfam12316
      Location:503 → 571
      Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

      Range
      56593044..56604611 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038601763.1 → XP_038457691.1  segment polarity protein dishevelled homolog DVL-1 isoform X2

    2. XM_038601762.1 → XP_038457690.1  segment polarity protein dishevelled homolog DVL-1 isoform X1

    3. XM_038601764.1 → XP_038457692.1  segment polarity protein dishevelled homolog DVL-1 isoform X3

      Conserved Domains (5) summary
      smart00021
      Location:1 → 85
      DAX; Domain present in Dishevelled and axin
      cd00992
      Location:249 → 336
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04438
      Location:417 → 499
      DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
      pfam02377
      Location:90 → 247
      Dishevelled; Dishevelled specific domain
      pfam12316
      Location:503 → 571
      Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

      Range
      56983289..56994870 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038537604.1 → XP_038393532.1  segment polarity protein dishevelled homolog DVL-1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0LSH9
      Conserved Domains (5) summary
      smart00021
      Location:1 → 85
      DAX; Domain present in Dishevelled and axin
      cd00992
      Location:249 → 336
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04438
      Location:392 → 474
      DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
      pfam02377
      Location:90 → 247
      Dishevelled; Dishevelled specific domain
      pfam12316
      Location:478 → 665
      Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

    2. XM_038537602.1 → XP_038393530.1  segment polarity protein dishevelled homolog DVL-1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0LSH9, A0A8I3PQU2
      Conserved Domains (5) summary
      smart00021
      Location:1 → 85
      DAX; Domain present in Dishevelled and axin
      cd00992
      Location:249 → 336
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04438
      Location:417 → 499
      DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
      pfam02377
      Location:90 → 247
      Dishevelled; Dishevelled specific domain
      pfam12316
      Location:503 → 690
      Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

    3. XM_038537605.1 → XP_038393533.1  segment polarity protein dishevelled homolog DVL-1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0LSH9
      Conserved Domains (5) summary
      smart00021
      Location:1 → 85
      DAX; Domain present in Dishevelled and axin
      cd00992
      Location:249 → 336
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04438
      Location:417 → 499
      DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
      pfam02377
      Location:90 → 247
      Dishevelled; Dishevelled specific domain
      pfam12316
      Location:503 → 571
      Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      56584127..56595703 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003639056.3 → XP_003639104.1  segment polarity protein dishevelled homolog DVL-1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0LSH9
      Conserved Domains (5) summary
      smart00021
      Location:1 → 85
      DAX; Domain present in Dishevelled and axin
      cd00992
      Location:249 → 336
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04438
      Location:392 → 474
      DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
      pfam02377
      Location:90 → 247
      Dishevelled; Dishevelled specific domain
      pfam12316
      Location:478 → 665
      Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

    2. XM_005620382.2 → XP_005620439.1  segment polarity protein dishevelled homolog DVL-1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KBS2, A0A8C0LSH9, A0A8C0Q2G1, A0A8P0SMX2
      Conserved Domains (5) summary
      smart00021
      Location:1 → 85
      DAX; Domain present in Dishevelled and axin
      cd00992
      Location:249 → 336
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04438
      Location:417 → 499
      DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
      pfam02377
      Location:90 → 247
      Dishevelled; Dishevelled specific domain
      pfam12316
      Location:503 → 690
      Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

    3. XM_014113809.3 → XP_013969284.1  segment polarity protein dishevelled homolog DVL-1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0LSH9
      Conserved Domains (5) summary
      smart00021
      Location:1 → 85
      DAX; Domain present in Dishevelled and axin
      cd00992
      Location:249 → 336
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04438
      Location:417 → 499
      DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
      pfam02377
      Location:90 → 247
      Dishevelled; Dishevelled specific domain
      pfam12316
      Location:503 → 571
      Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal
    Nucleotide Protein
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