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    Mlh1 mutL homolog 1 [ Cricetulus griseus (Chinese hamster) ]

    Gene ID: 100769879, updated on 8-Mar-2024

    Summary

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    Gene symbol
    Mlh1
    Gene description
    mutL homolog 1
    Locus tag
    I79_014127
    See related
    Ensembl:ENSCGRG00015018967
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Cricetulus griseus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Cricetulus
    Orthologs
    human mouse all
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    Genomic context

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    See Mlh1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    104 current CriGri_1.0 (GCF_000223135.1) Unplaced Scaffold NW_003614270.1 (441633..490372, complement)
    104 current CriGri-PICRH-1.0 (GCF_003668045.3) 4 NC_048597.1 (218700079..218748661, complement)

    NW_003614270.1Genomic Context describing neighboring genes Neighboring gene lactotransferrin Neighboring gene C-C motif chemokine receptor like 2 Neighboring gene LRR binding FLII interacting protein 2 Neighboring gene EPM2A interacting protein 1 Neighboring gene tetratricopeptide repeat and ankyrin repeat containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing. Becker J, et al. J Biotechnol, 2011 Dec 10. PMID 21945585

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP-dependent DNA damage sensor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables mismatched DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mismatch repair IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MutLalpha complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA mismatch repair protein Mlh1
    Names
    DNA mismatch repair protein Mlh1-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Cricetulus griseus Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference CriGri_1.0 Primary Assembly

    Genomic

    1. NW_003614270.1 Reference CriGri_1.0 Primary Assembly

      Range
      441633..490372 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003506671.5 → XP_003506719.1  DNA mismatch repair protein Mlh1 isoform X1

      UniProtKB/TrEMBL
      A0A061I7W4, G3HTA5
      Conserved Domains (4) summary
      cd03483
      Location:211 → 335
      MutL_Trans_MLH1; MutL_Trans_MLH1: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH1 (MutL homologue 1). This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to ...
      TIGR00585
      Location:6 → 315
      mutl; DNA mismatch repair protein MutL
      pfam16413
      Location:496 → 751
      Mlh1_C; DNA mismatch repair protein Mlh1 C-terminus
      cl00075
      Location:31 → 132
      HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins

    2. XM_035458537.1 → XP_035314428.1  DNA mismatch repair protein Mlh1 isoform X2

      UniProtKB/TrEMBL
      A0A9J7GVV8
      Conserved Domains (2) summary
      cd03483
      Location:72 → 196
      MutL_Trans_MLH1; transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH1 (MutL homologue 1). This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in ...
      pfam16413
      Location:358 → 612
      Mlh1_C; DNA mismatch repair protein Mlh1 C-terminus

    RNA

    1. XR_004774293.1 RNA Sequence

    Alternate CriGri-PICRH-1.0

    Genomic

    1. NC_048597.1 Alternate CriGri-PICRH-1.0

      Range
      218700079..218748661 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_027414720.2 → XP_027270521.1  DNA mismatch repair protein Mlh1 isoform X1

      UniProtKB/TrEMBL
      A0A061I7W4, G3HTA5
      Related
      ENSCGRP00015040878.1, ENSCGRT00015069579.1

    2. XM_035444013.1 → XP_035299904.1  DNA mismatch repair protein Mlh1 isoform X2

      UniProtKB/TrEMBL
      A0A9J7GVV8
      Conserved Domains (2) summary
      cd03483
      Location:72 → 196
      MutL_Trans_MLH1; transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH1 (MutL homologue 1). This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in ...
      pfam16413
      Location:358 → 612
      Mlh1_C; DNA mismatch repair protein Mlh1 C-terminus

    RNA

    1. XR_004769772.1 RNA Sequence

      Related
      ENSCGRT00015083549.1
    Nucleotide Protein Strain
    Heading Accession and Version

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