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    Bace1 beta-secretase 1 [ Cricetulus griseus (Chinese hamster) ]

    Gene ID: 100762079, updated on 8-Mar-2024

    Summary

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    Gene symbol
    Bace1
    Gene description
    beta-secretase 1
    See related
    Ensembl:ENSCGRG00015018442
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Cricetulus griseus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Cricetulus
    Orthologs
    human mouse all
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    Genomic context

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    See Bace1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    104 current CriGri_1.0 (GCF_000223135.1) Unplaced Scaffold NW_003615296.1 (102919..129209, complement)
    104 current CriGri-PICRH-1.0 (GCF_003668045.3) 4 NC_048597.1 (157566683..157593312)

    NW_003615296.1Genomic Context describing neighboring genes Neighboring gene proprotein convertase subtilisin/kexin type 7 Neighboring gene ring finger protein 214 Neighboring gene centrosomal protein 164 Neighboring gene DS cell adhesion molecule like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amyloid-beta metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in membrane protein ectodomain proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    beta-secretase 1
    Names
    beta-site APP-cleaving enzyme 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Cricetulus griseus Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference CriGri_1.0 Primary Assembly

    Genomic

    1. NW_003615296.1 Reference CriGri_1.0 Primary Assembly

      Range
      102919..129209 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003511973.5 → XP_003512021.1  beta-secretase 1

      See identical proteins and their annotated locations for XP_003512021.1

      UniProtKB/TrEMBL
      A0A8C2MNZ9, G3IAK4
      Conserved Domains (2) summary
      cd05473
      Location:72 → 437
      beta_secretase_like; Beta-secretase, aspartic-acid protease important in the pathogenesis of Alzheimer's disease
      pfam00026
      Location:75 → 416
      Asp; Eukaryotic aspartyl protease

    Alternate CriGri-PICRH-1.0

    Genomic

    1. NC_048597.1 Alternate CriGri-PICRH-1.0

      Range
      157566683..157593312
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_027412039.2 → XP_027267840.1  beta-secretase 1

      UniProtKB/TrEMBL
      A0A8C2MNZ9, G3IAK4
      Related
      ENSCGRP00015024304.2, ENSCGRT00015029816.2
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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