U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Slc26a5 solute carrier family 26 member 5 [ Cavia porcellus (domestic guinea pig) ]

    Gene ID: 100727496, updated on 8-Mar-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    Slc26a5
    Gene description
    solute carrier family 26 member 5
    See related
    Ensembl:ENSCPOG00000008126
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Cavia porcellus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae; Cavia
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: Un
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current mCavPor4.1 (GCF_034190915.1) Unplaced Scaffold NW_026947485.1 (8748641..8775885, complement)
    103 previous assembly Cavpor3.0 (GCF_000151735.1) Unplaced Scaffold NT_176388.1 (16777755..16804999)

    NW_026947485.1Genomic Context describing neighboring genes Neighboring gene peptidase, mitochondrial processing subunit beta Neighboring gene DnaJ heat shock protein family (Hsp40) member C2 Neighboring gene proteasome 26S subunit, ATPase 2 Neighboring gene reelin Neighboring gene uncharacterized LOC134473472 Neighboring gene uncharacterized LOC134473473

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. State dependent effects on the frequency response of prestin's real and imaginary components of nonlinear capacitance. Santos-Sacchi J, et al. Sci Rep, 2021 Aug 9. PMID 34373481, Free PMC Article
    2. Complex nonlinear capacitance in outer hair cell macro-patches: effects of membrane tension. Santos-Sacchi J, et al. Sci Rep, 2020 Apr 10. PMID 32277153, Free PMC Article
    3. Chloride Anions Regulate Kinetics but Not Voltage-Sensor Qmax of the Solute Carrier SLC26a5. Santos-Sacchi J, et al. Biophys J, 2016 Jun 7. PMID 27276272, Free PMC Article
    4. The influence of cholesterol on the motility of cochlear outer hair cells and the motor protein prestin. Canis M, et al. Acta Otolaryngol, 2009 Sep. PMID 19153847

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. State dependent effects on the frequency response of prestin's real and imaginary components of nonlinear capacitance.
      Title: State dependent effects on the frequency response of prestin's real and imaginary components of nonlinear capacitance.
    2. Complex nonlinear capacitance in outer hair cell macro-patches: effects of membrane tension.
      Title: Complex nonlinear capacitance in outer hair cell macro-patches: effects of membrane tension.
    3. Cholesterol modulates outer hair cell electromotility mainly by influencing the motor protein prestin.
      Title: The influence of cholesterol on the motility of cochlear outer hair cells and the motor protein prestin.
    4. Results indicate that prestin activity is significantly low-pass in the frequency domain, with important implications for cochlear amplification; chloride influences prestin kinetics
      Title: Chloride Anions Regulate Kinetics but Not Voltage-Sensor Qmax of the Solute Carrier SLC26a5.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables bicarbonate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables chloride transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables oxalate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables secondary active sulfate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in sulfate transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    prestin
    Names
    solute carrier family 26, member 5 (prestin)

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_034190915.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mCavPor4.1

    Genomic

    1. NW_026947485.1 Reference mCavPor4.1

      Range
      8748641..8775885 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_013152398.1 → XP_013007852.1  prestin isoform X3

      UniProtKB/TrEMBL
      A0A286X8M1
      Related
      ENSCPOP00000021764.1, ENSCPOT00000038047.1
      Conserved Domains (2) summary
      cd07042
      Location:489 → 657
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      TIGR00815
      Location:66 → 672
      sulP; high affinity sulphate transporter 1

    2. XM_003469806.1 → XP_003469854.1  prestin isoform X2

      Conserved Domains (2) summary
      cd07042
      Location:494 → 662
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      TIGR00815
      Location:66 → 677
      sulP; high affinity sulphate transporter 1

    3. XM_003469805.1 → XP_003469853.1  prestin isoform X1

      UniProtKB/TrEMBL
      H0VBM0
      Related
      ENSCPOP00000007307.3, ENSCPOT00000008201.3
      Conserved Domains (2) summary
      cd07042
      Location:526 → 694
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      TIGR00815
      Location:66 → 709
      sulP; high affinity sulphate transporter 1
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials