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    F2 coagulation factor II, thrombin [ Cavia porcellus (domestic guinea pig) ]

    Gene ID: 100725988, updated on 3-Apr-2024

    Summary

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    Gene symbol
    F2
    Gene description
    coagulation factor II, thrombin
    See related
    Ensembl:ENSCPOG00000026682
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Cavia porcellus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae; Cavia
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: Un
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current mCavPor4.1 (GCF_034190915.1) Unplaced Scaffold NW_026947500.1 (43261497..43276584)
    103 previous assembly Cavpor3.0 (GCF_000151735.1) Unplaced Scaffold NT_176347.1 (6142408..6157494)

    NW_026947500.1Genomic Context describing neighboring genes Neighboring gene autophagy related 13 Neighboring gene Rho GTPase activating protein 1 Neighboring gene uncharacterized LOC100725717 Neighboring gene small nucleolar RNA SNORD67 Neighboring gene cytoskeleton associated protein 5 Neighboring gene 26S proteasome regulatory subunit 6A-A-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in platelet activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    prothrombin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_034190915.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mCavPor4.1

    Genomic

    1. NW_026947500.1 Reference mCavPor4.1

      Range
      43261497..43276584
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003465144.5 → XP_003465192.2  prothrombin

      UniProtKB/TrEMBL
      H0VZS4
      Conserved Domains (5) summary
      smart00020
      Location:365 → 615
      Tryp_SPc; Trypsin-like serine protease
      smart00069
      Location:31 → 93
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      smart00130
      Location:111 → 193
      KR; Kringle domain
      cd00190
      Location:366 → 618
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam09396
      Location:318 → 365
      Thrombin_light; Thrombin light chain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials