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    Wwp2 WW domain containing E3 ubiquitin protein ligase 2 [ Cavia porcellus (domestic guinea pig) ]

    Gene ID: 100721341, updated on 8-Mar-2024

    Summary

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    Gene symbol
    Wwp2
    Gene description
    WW domain containing E3 ubiquitin protein ligase 2
    See related
    Ensembl:ENSCPOG00000010208
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Cavia porcellus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae; Cavia
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: Un
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current mCavPor4.1 (GCF_034190915.1) Unplaced Scaffold NW_026947487.1 (102034072..102166391)
    103 previous assembly Cavpor3.0 (GCF_000151735.1) Unplaced Scaffold NT_176397.1 (6804971..6936486, complement)

    NW_026947487.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111757428 Neighboring gene NAD(P)H quinone dehydrogenase 1 Neighboring gene NIN1 (RPN12) binding protein 1 homolog Neighboring gene small nucleolar RNA SNORA2/SNORA34 family Neighboring gene proteasome 26S subunit, non-ATPase 7 Neighboring gene uncharacterized LOC134475628

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein K63-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NEDD4-like E3 ubiquitin-protein ligase WWP2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_034190915.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mCavPor4.1

    Genomic

    1. NW_026947487.1 Reference mCavPor4.1

      Range
      102034072..102166391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003471980.4 → XP_003472028.1  NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1

      See identical proteins and their annotated locations for XP_003472028.1

      UniProtKB/TrEMBL
      A0A286XQI4, H0VGD4
      Conserved Domains (5) summary
      cd04021
      Location:17 → 142
      C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
      cd00078
      Location:516 → 868
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:447 → 477
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:332 → 361
      WW; WW domain
      cl25495
      Location:143 → 300
      Endomucin; Endomucin

    2. XM_005004630.4 → XP_005004687.1  NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1

      See identical proteins and their annotated locations for XP_005004687.1

      UniProtKB/TrEMBL
      A0A286XQI4, H0VGD4
      Related
      ENSCPOP00000009169.3
      Conserved Domains (5) summary
      cd04021
      Location:17 → 142
      C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
      cd00078
      Location:516 → 868
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:447 → 477
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:332 → 361
      WW; WW domain
      cl25495
      Location:143 → 300
      Endomucin; Endomucin

    3. XM_023565970.2 → XP_023421738.1  NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1

      UniProtKB/TrEMBL
      A0A286XQI4, H0VGD4
      Conserved Domains (5) summary
      cd04021
      Location:17 → 142
      C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
      cd00078
      Location:516 → 868
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:447 → 477
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:332 → 361
      WW; WW domain
      cl25495
      Location:143 → 300
      Endomucin; Endomucin

    4. XM_005004629.4 → XP_005004686.1  NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1

      See identical proteins and their annotated locations for XP_005004686.1

      UniProtKB/TrEMBL
      A0A286XQI4, H0VGD4
      Conserved Domains (5) summary
      cd04021
      Location:17 → 142
      C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
      cd00078
      Location:516 → 868
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:447 → 477
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:332 → 361
      WW; WW domain
      cl25495
      Location:143 → 300
      Endomucin; Endomucin

    5. XM_063247585.1 → XP_063103655.1  NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X2

    Nucleotide Protein
    Heading Accession and Version

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