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    Mmp2 matrix metallopeptidase 2 [ Cavia porcellus (domestic guinea pig) ]

    Gene ID: 100719361, updated on 8-Mar-2024

    Summary

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    Gene symbol
    Mmp2
    Gene description
    matrix metallopeptidase 2
    See related
    Ensembl:ENSCPOG00000020846
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Cavia porcellus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae; Cavia
    Orthologs
    human mouse all
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    Genomic context

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    See Mmp2 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current mCavPor4.1 (GCF_034190915.1) Unplaced Scaffold NW_026947487.1 (56330512..56355225, complement)
    103 previous assembly Cavpor3.0 (GCF_000151735.1) Unplaced Scaffold NT_176414.1 (13320648..13345591)

    NW_026947487.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 member 2 Neighboring gene lysophosphatidylcholine acyltransferase 2 Neighboring gene calpain small subunit 2 Neighboring gene uncharacterized LOC134475600 Neighboring gene uncharacterized LOC134475601

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effects of glucocorticoid on the eye development in guinea pigs. Ding M, et al. Steroids, 2018 Nov. PMID 30244069
    2. The sonic hedgehog signaling pathway induces myopic development by activating matrix metalloproteinase (MMP)-2 in Guinea pigs. Chen M, et al. PLoS One, 2014. PMID 24810957, Free PMC Article
    3. [Effects of blocking activation of IGF-1-Stat3 signaling pathway in guinea pig sclera fibroblast by AG490 on expression of MMP-2 and Integrinβ(1)]. Zhu ZC, et al. Zhonghua Yan Ke Za Zhi, 2011 Apr. PMID 21612683
    4. Expression characteristics of MMP-2 and MMP-9 in guinea pig ovaries during the estrous cycle. Li JR, et al. Genet Mol Res, 2015 Dec 21. PMID 26782373
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. in normal eye development, hydrocortisone could inhibit both the axial elongation and the myopic shift; whereas (2) in lens-induced myopia eye development, hydrocortisone (a) enhanced the axial elongation, myopic shift and sclera thinning; (b) enhanced the MMP-2 expression and decreased TIMP-2 expression
      Title: Effects of glucocorticoid on the eye development in guinea pigs.
    2. The results showed that MMP-2, MMP-9, and StAR were significantly expressed in the granulosa and thecal cells of the ovarian atretic follicles during proestrus, and were strongly expressed in the corpus luteum during metestrus.
      Title: Expression characteristics of MMP-2 and MMP-9 in guinea pig ovaries during the estrous cycle.
    3. Shh signaling pathway induces myopic development by activating MMP-2 in guinea pigs
      Title: The sonic hedgehog signaling pathway induces myopic development by activating matrix metalloproteinase (MMP)-2 in Guinea pigs.
    4. Activation of Stat3 signaling pathway may be involved in up-modulating the expression of MMP-2 in guinea pig sclera fibroblasts, and not affect integrinbeta(1) expression.
      Title: [Effects of blocking activation of IGF-1-Stat3 signaling pathway in guinea pig sclera fibroblast by AG490 on expression of MMP-2 and Integrinβ(1)].
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in collagen catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tissue remodeling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    72 kDa type IV collagenase
    Names
    matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_034190915.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mCavPor4.1

    Genomic

    1. NW_026947487.1 Reference mCavPor4.1

      Range
      56330512..56355225 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003477541.5 → XP_003477589.2  72 kDa type IV collagenase

    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials