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    Lig3 DNA ligase 3 [ Cavia porcellus (domestic guinea pig) ]

    Gene ID: 100716163, updated on 8-Mar-2024

    Summary

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    Gene symbol
    Lig3
    Gene description
    DNA ligase 3
    See related
    Ensembl:ENSCPOG00000013032
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Cavia porcellus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae; Cavia
    Orthologs
    human mouse all
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    Genomic context

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    See Lig3 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current mCavPor4.1 (GCF_034190915.1) Unplaced Scaffold NW_026947489.1 (68226704..68247300, complement)
    103 previous assembly Cavpor3.0 (GCF_000151735.1) Unplaced Scaffold NT_176387.1 (11955765..11976368, complement)

    NW_026947489.1Genomic Context describing neighboring genes Neighboring gene RAD51 paralog D Neighboring gene small nucleolar RNA SNORA73 family Neighboring gene ring finger and FYVE like domain containing E3 ubiquitin protein ligase Neighboring gene chaperonin containing TCP1 subunit 6B Neighboring gene zinc finger protein 830 Neighboring gene RNA-binding protein 45-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA ligase (ATP) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in base-excision repair, DNA ligation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in double-strand break repair IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in lagging strand elongation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DNA ligase III-XRCC1 complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA ligase 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_034190915.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mCavPor4.1

    Genomic

    1. NW_026947489.1 Reference mCavPor4.1

      Range
      68226704..68247300 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005003523.4 → XP_005003580.1  DNA ligase 3 isoform X2

      UniProtKB/TrEMBL
      A0A286XHF3, H0VMT6
      Related
      ENSCPOP00000011732.3
      Conserved Domains (7) summary
      cd07967
      Location:685 → 823
      OBF_DNA_ligase_III; The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase III is a DNA-binding module that is part of the catalytic core unit
      cd07902
      Location:467 → 679
      Adenylation_DNA_ligase_III; Adenylation domain of DNA Ligase III
      TIGR00574
      Location:317 → 829
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00645
      Location:96 → 178
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam01101
      Location:873 → 923
      HMG14_17; HMG14 and HMG17
      pfam04675
      Location:263 → 428
      DNA_ligase_A_N; DNA ligase N terminus
      pfam16759
      Location:936 → 1007
      LIG3_BRCT; DNA ligase 3 BRCT domain

    2. XM_005003522.4 → XP_005003579.1  DNA ligase 3 isoform X1

      UniProtKB/TrEMBL
      A0A286XHF3
      Conserved Domains (7) summary
      cd07967
      Location:740 → 878
      OBF_DNA_ligase_III; The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase III is a DNA-binding module that is part of the catalytic core unit
      cd07902
      Location:522 → 734
      Adenylation_DNA_ligase_III; Adenylation domain of DNA Ligase III
      TIGR00574
      Location:372 → 884
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00645
      Location:151 → 233
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam01101
      Location:928 → 978
      HMG14_17; HMG14 and HMG17
      pfam04675
      Location:318 → 483
      DNA_ligase_A_N; DNA ligase N terminus
      pfam16759
      Location:991 → 1062
      LIG3_BRCT; DNA ligase 3 BRCT domain

    3. XM_003469610.5 → XP_003469658.2  DNA ligase 3 isoform X3

      UniProtKB/TrEMBL
      A0A286XW99
      Related
      ENSCPOP00000029612.1
      Conserved Domains (6) summary
      cd07967
      Location:740 → 878
      OBF_DNA_ligase_III; The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase III is a DNA-binding module that is part of the catalytic core unit
      cd07902
      Location:522 → 734
      Adenylation_DNA_ligase_III; Adenylation domain of DNA Ligase III
      TIGR00574
      Location:372 → 884
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00645
      Location:151 → 233
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam01101
      Location:928 → 978
      HMG14_17; HMG14 and HMG17
      pfam04675
      Location:318 → 483
      DNA_ligase_A_N; DNA ligase N terminus

    RNA

    1. XR_010048172.1 RNA Sequence

    2. XR_010048173.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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