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    Sesn1 sestrin 1 [ Cavia porcellus (domestic guinea pig) ]

    Gene ID: 100713452, updated on 10-Oct-2024

    Summary

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    Gene symbol
    Sesn1
    Gene description
    sestrin 1
    See related
    Ensembl:ENSCPOG00000013793
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Cavia porcellus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae; Cavia
    Orthologs
    human mouse all
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    Genomic context

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    See Sesn1 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current mCavPor4.1 (GCF_034190915.1) Unplaced Scaffold NW_026947490.1 (96924197..97028675, complement)
    103 previous assembly Cavpor3.0 (GCF_000151735.1) Unplaced Scaffold NT_176356.1 (8558998..8659817, complement)

    NW_026947490.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111755696 Neighboring gene uncharacterized LOC106026813 Neighboring gene U6 spliceosomal RNA Neighboring gene armadillo repeat containing 2 Neighboring gene centrosomal protein 57 like 1 Neighboring gene uncharacterized LOC134477071 Neighboring gene 5S ribosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables L-leucine binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on peroxide as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to L-leucine IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to leucine starvation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of TORC1 signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of macroautophagy IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of response to reactive oxygen species IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sestrin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_034190915.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mCavPor4.1

    Genomic

    1. NW_026947490.1 Reference mCavPor4.1

      Range
      96924197..97028675 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003466035.5 → XP_003466083.2  sestrin-1 isoform X1

      UniProtKB/TrEMBL
      A0A286XZ24, H0VPK0
      Related
      ENSCPOP00000012427.3
      Conserved Domains (1) summary
      pfam04636
      Location:119 → 563
      PA26; PA26 p53-induced protein (sestrin)

    2. XM_013148515.3 → XP_013003969.1  sestrin-1 isoform X2

      Conserved Domains (1) summary
      pfam04636
      Location:119 → 488
      PA26; PA26 p53-induced protein (sestrin)

    3. XM_005002019.4 → XP_005002076.2  sestrin-1 isoform X3

    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials