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    NAPEPLD N-acyl phosphatidylethanolamine phospholipase D [ Canis lupus familiaris (dog) ]

    Gene ID: 100685330, updated on 17-Aug-2024

    Summary

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    Official Symbol
    NAPEPLDprovided by VGNC
    Official Full Name
    N-acyl phosphatidylethanolamine phospholipase Dprovided by VGNC
    Primary source
    VGNC:VGNC:43621
    See related
    Ensembl:ENSCAFG00845019563
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 18
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 18 NC_051822.1 (17253389..17307355)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 18 NC_006600.4 (16599554..16650199)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 18 NC_049239.1 (17219297..17269945)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 18 NC_049278.1 (17011890..17062566)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 18 NC_049759.1 (16950687..17001305)

    Chromosome 18 - NC_051822.1Genomic Context describing neighboring genes Neighboring gene proteasome 26S subunit, ATPase 2 Neighboring gene DnaJ heat shock protein family (Hsp40) member C2 Neighboring gene peptidase, mitochondrial processing subunit beta Neighboring gene armadillo repeat containing 10 Neighboring gene F-box and leucine rich repeat protein 13 Neighboring gene leucine rich repeat containing 17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Canine NAPEPLD-associated models of human myelin disorders. Minor KM, et al. Sci Rep, 2018 Apr 11. PMID 29643404, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables N-acylphosphatidylethanolamine-specific phospholipase D activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in N-acylethanolamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in N-acylphosphatidylethanolamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D
    XP_038279822.1
    XP_038279823.1
    XP_038279824.1
    XP_038279825.1
    XP_038279826.1
    XP_038279827.1
    XP_038310105.1
    XP_038310106.1
    XP_038310107.1
    XP_038310108.1
    XP_038310109.1
    XP_038310110.1
    XP_038356183.1
    XP_038356184.1
    XP_038356185.1
    XP_038356186.1
    XP_038356187.1
    XP_038356188.1
    XP_038418729.1
    XP_038418730.1
    XP_038418731.1
    XP_038418732.1
    XP_038418733.1
    XP_038418734.1
    XP_038482851.1
    XP_038482852.1
    XP_038482853.1
    XP_038482854.1
    XP_038482855.1
    XP_038482856.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051822.1 Reference ROS_Cfam_1.0

      Range
      17253389..17307355
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038423895.1 → XP_038279823.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X2

      UniProtKB/TrEMBL
      A0A8C0RKQ9, A0A8C0SPU0, A0A8I3S423, A0A8P0S9V5
      Conserved Domains (1) summary
      cl23716
      Location:136 → 323
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    2. XM_038423896.1 → XP_038279824.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1

      UniProtKB/TrEMBL
      A0A240DXG8, A0A8C0LAA8, A0A8C0RKQ9, A0A8C0SPA6, A0A8I3S423
      Related
      ENSCAFP00845027105.1, ENSCAFT00845034597.1
      Conserved Domains (1) summary
      cl23716
      Location:129 → 316
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    3. XM_038423898.1 → XP_038279826.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1

      UniProtKB/TrEMBL
      A0A240DXG8, A0A8C0LAA8, A0A8C0RKQ9, A0A8C0SPA6, A0A8I3S423
      Conserved Domains (1) summary
      cl23716
      Location:129 → 316
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    4. XM_038423899.1 → XP_038279827.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1

      UniProtKB/TrEMBL
      A0A240DXG8, A0A8C0LAA8, A0A8C0RKQ9, A0A8C0SPA6, A0A8I3S423
      Conserved Domains (1) summary
      cl23716
      Location:129 → 316
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    5. XM_038423897.1 → XP_038279825.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1

      UniProtKB/TrEMBL
      A0A240DXG8, A0A8C0LAA8, A0A8C0RKQ9, A0A8C0SPA6, A0A8I3S423
      Conserved Domains (1) summary
      cl23716
      Location:129 → 316
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    6. XM_038423894.1 → XP_038279822.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1

      UniProtKB/TrEMBL
      A0A240DXG8, A0A8C0LAA8, A0A8C0RKQ9, A0A8C0SPA6, A0A8I3S423
      Conserved Domains (1) summary
      cl23716
      Location:129 → 316
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049278.1 Alternate UMICH_Zoey_3.1

      Range
      17011890..17062566
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038500256.1 → XP_038356184.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X2

      Conserved Domains (1) summary
      cl23716
      Location:136 → 323
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    2. XM_038500257.1 → XP_038356185.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1

      Conserved Domains (1) summary
      cl23716
      Location:129 → 316
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    3. XM_038500259.1 → XP_038356187.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1

      Conserved Domains (1) summary
      cl23716
      Location:129 → 316
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    4. XM_038500260.1 → XP_038356188.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1

      Conserved Domains (1) summary
      cl23716
      Location:129 → 316
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    5. XM_038500258.1 → XP_038356186.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1

      Conserved Domains (1) summary
      cl23716
      Location:129 → 316
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    6. XM_038500255.1 → XP_038356183.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1

      Conserved Domains (1) summary
      cl23716
      Location:129 → 316
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049759.1 Alternate UNSW_CanFamBas_1.0

      Range
      16950687..17001305
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038626924.1 → XP_038482852.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X2

      Conserved Domains (1) summary
      cl23716
      Location:136 → 323
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    2. XM_038626925.1 → XP_038482853.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1

      Conserved Domains (1) summary
      cl23716
      Location:129 → 316
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    3. XM_038626927.1 → XP_038482855.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1

      Conserved Domains (1) summary
      cl23716
      Location:129 → 316
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    4. XM_038626928.1 → XP_038482856.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1

      Conserved Domains (1) summary
      cl23716
      Location:129 → 316
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    5. XM_038626926.1 → XP_038482854.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1

      Conserved Domains (1) summary
      cl23716
      Location:129 → 316
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    6. XM_038626923.1 → XP_038482851.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1

      Conserved Domains (1) summary
      cl23716
      Location:129 → 316
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049239.1 Alternate UU_Cfam_GSD_1.0

      Range
      17219297..17269945
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038562802.1 → XP_038418730.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X2

      UniProtKB/TrEMBL
      A0A8C0RKQ9, A0A8C0SPU0, A0A8I3S423, A0A8P0S9V5
      Conserved Domains (1) summary
      cl23716
      Location:136 → 323
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    2. XM_038562803.1 → XP_038418731.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1

      UniProtKB/TrEMBL
      A0A240DXG8, A0A8C0LAA8, A0A8C0RKQ9, A0A8C0SPA6, A0A8I3S423
      Conserved Domains (1) summary
      cl23716
      Location:129 → 316
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    3. XM_038562805.1 → XP_038418733.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1

      UniProtKB/TrEMBL
      A0A240DXG8, A0A8C0LAA8, A0A8C0RKQ9, A0A8C0SPA6, A0A8I3S423
      Conserved Domains (1) summary
      cl23716
      Location:129 → 316
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    4. XM_038562806.1 → XP_038418734.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1

      UniProtKB/TrEMBL
      A0A240DXG8, A0A8C0LAA8, A0A8C0RKQ9, A0A8C0SPA6, A0A8I3S423
      Conserved Domains (1) summary
      cl23716
      Location:129 → 316
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    5. XM_038562804.1 → XP_038418732.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1

      UniProtKB/TrEMBL
      A0A240DXG8, A0A8C0LAA8, A0A8C0RKQ9, A0A8C0SPA6, A0A8I3S423
      Conserved Domains (1) summary
      cl23716
      Location:129 → 316
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    6. XM_038562801.1 → XP_038418729.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1

      UniProtKB/TrEMBL
      A0A240DXG8, A0A8C0LAA8, A0A8C0RKQ9, A0A8C0SPA6, A0A8I3S423
      Conserved Domains (1) summary
      cl23716
      Location:129 → 316
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006600.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      16599554..16650199
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038454178.1 → XP_038310106.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X2

      UniProtKB/TrEMBL
      A0A8C0RKQ9, A0A8C0SPU0, A0A8I3S423, A0A8P0S9V5
      Conserved Domains (1) summary
      cl23716
      Location:136 → 323
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    2. XM_038454179.1 → XP_038310107.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1

      UniProtKB/TrEMBL
      A0A240DXG8, A0A8C0LAA8, A0A8C0RKQ9, A0A8C0SPA6, A0A8I3S423
      Conserved Domains (1) summary
      cl23716
      Location:129 → 316
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    3. XM_038454181.1 → XP_038310109.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1

      UniProtKB/TrEMBL
      A0A240DXG8, A0A8C0LAA8, A0A8C0RKQ9, A0A8C0SPA6, A0A8I3S423
      Conserved Domains (1) summary
      cl23716
      Location:129 → 316
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    4. XM_038454182.1 → XP_038310110.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1

      UniProtKB/TrEMBL
      A0A240DXG8, A0A8C0LAA8, A0A8C0RKQ9, A0A8C0SPA6, A0A8I3S423
      Conserved Domains (1) summary
      cl23716
      Location:129 → 316
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    5. XM_038454180.1 → XP_038310108.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1

      UniProtKB/TrEMBL
      A0A240DXG8, A0A8C0LAA8, A0A8C0RKQ9, A0A8C0SPA6, A0A8I3S423
      Conserved Domains (1) summary
      cl23716
      Location:129 → 316
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    6. XM_038454177.1 → XP_038310105.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1

      UniProtKB/TrEMBL
      A0A240DXG8, A0A8C0LAA8, A0A8C0RKQ9, A0A8C0SPA6, A0A8I3S423
      Conserved Domains (1) summary
      cl23716
      Location:129 → 316
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
    Nucleotide Protein
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