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    NR5A2 nuclear receptor subfamily 5 group A member 2 [ Ovis aries (sheep) ]

    Gene ID: 100653388, updated on 8-Mar-2024

    Summary

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    Gene symbol
    NR5A2
    Gene description
    nuclear receptor subfamily 5 group A member 2
    See related
    EnsemblRapid:ENSOARG00020015025
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Ovis aries
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
    Also known as
    LRH-1
    Orthologs
    human mouse all
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    Genomic context

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    See NR5A2 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 12 NC_056065.1 (78268632..78396350)

    Chromosome 12 - NC_056065.1Genomic Context describing neighboring genes Neighboring gene microRNA mir-181a-1 Neighboring gene uncharacterized LOC121816067 Neighboring gene protein FAM50A Neighboring gene tumor protein, translationally-controlled 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_056065.1 Chromosome 12 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization and expression analysis of the Lrh-1 gene in Chinese Hu sheep. Wang LH, et al. Genet Mol Res, 2013 May 6. PMID 23765956
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclear receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in hormone-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tissue development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nuclear receptor subfamily 5 group A member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001246280.1 → NP_001233209.1  nuclear receptor subfamily 5 group A member 2

      See identical proteins and their annotated locations for NP_001233209.1

      Status: PROVISIONAL

      Source sequence(s)
      JN182926
      UniProtKB/TrEMBL
      A0A6P9FQT4, G1FEX2, W5Q376
      Conserved Domains (2) summary
      cd07069
      Location:255 → 495
      NR_LBD_Lrh-1; The ligand binding domain of the liver receptor homolog-1, a member of nuclear receptor superfamily,
      cd07167
      Location:40 → 132
      NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Genomic

    1. NC_056065.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

      Range
      78268632..78396350
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_027975556.3 → XP_027831357.1  nuclear receptor subfamily 5 group A member 2 isoform X6

      UniProtKB/TrEMBL
      W5Q376
      Related
      ENSOARP00020019208.1, ENSOART00020023164.2

    2. XM_027975555.3 → XP_027831356.1  nuclear receptor subfamily 5 group A member 2 isoform X1

      UniProtKB/TrEMBL
      A0A6P7EMX3, W5Q376
      Related
      ENSOARP00020053211.1, ENSOART00020063813.1
      Conserved Domains (2) summary
      cd07069
      Location:261 → 501
      NR_LBD_Lrh-1; The ligand binding domain of the liver receptor homolog-1, a member of nuclear receptor superfamily,
      cd07167
      Location:46 → 138
      NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers

    3. XM_027975554.3 → XP_027831355.1  nuclear receptor subfamily 5 group A member 2 isoform X3

      UniProtKB/TrEMBL
      W5Q376
      Related
      ENSOARP00020042421.1, ENSOART00020069423.1

    4. XM_042256839.2 → XP_042112773.1  nuclear receptor subfamily 5 group A member 2 isoform X5

      UniProtKB/TrEMBL
      W5Q376
      Conserved Domains (2) summary
      cd07069
      Location:229 → 469
      NR_LBD_Lrh-1; The ligand binding domain of the liver receptor homolog-1, a member of nuclear receptor superfamily,
      cd07167
      Location:14 → 106
      NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers

    5. XM_042256838.2 → XP_042112772.1  nuclear receptor subfamily 5 group A member 2 isoform X2

      UniProtKB/TrEMBL
      W5Q376
      Related
      ENSOARP00020046295.1, ENSOART00020046091.1
      Conserved Domains (2) summary
      cd07069
      Location:246 → 486
      NR_LBD_Lrh-1; The ligand binding domain of the liver receptor homolog-1, a member of nuclear receptor superfamily,
      cd07167
      Location:31 → 123
      NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers

    6. XM_042256840.2 → XP_042112774.1  nuclear receptor subfamily 5 group A member 2 isoform X5

      UniProtKB/TrEMBL
      W5Q376
      Conserved Domains (2) summary
      cd07069
      Location:229 → 469
      NR_LBD_Lrh-1; The ligand binding domain of the liver receptor homolog-1, a member of nuclear receptor superfamily,
      cd07167
      Location:14 → 106
      NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers

    7. XM_060395930.1 → XP_060251913.1  nuclear receptor subfamily 5 group A member 2 isoform X4

      Related
      ENSOARP00020019159.2, ENSOART00020023103.2
    Nucleotide Protein Strain
    Heading Accession and Version

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