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    ASGR1 asialoglycoprotein receptor 1 [ Sus scrofa (pig) ]

    Gene ID: 100625649, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ASGR1provided by VGNC
    Official Full Name
    asialoglycoprotein receptor 1provided by VGNC
    Primary source
    VGNC:VGNC:85575
    See related
    Ensembl:ENSSSCG00000024926
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Biased expression in liver (RPKM 230.0) and mixtures (RPKM 84.6) See more
    Orthologs
    human all
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    Genomic context

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    See ASGR1 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 12 NC_010454.4 (52536738..52540636, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 3 NC_010445.3 (139811186..139815058, complement)

    Chromosome 12 - NC_010454.4Genomic Context describing neighboring genes Neighboring gene asialoglycoprotein receptor 2 Neighboring gene uncharacterized LOC110256107 Neighboring gene 40S ribosomal protein SA pseudogene Neighboring gene discs large MAGUK scaffold protein 4 Neighboring gene acyl-CoA dehydrogenase very long chain Neighboring gene microRNA mir-324

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Porcine extrahepatic vascular endothelial asialoglycoprotein receptor 1 mediates xenogeneic platelet phagocytosis in vitro and in human-to-pig ex vivo xenoperfusion. Bongoni AK, et al. Transplantation, 2015 Apr. PMID 25675194
    2. PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences. Uenishi H, et al. Nucleic Acids Res, 2007 Jan. PMID 17145712, Free PMC Article
    3. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The ASGR1 expressed on aortic and limb arterial pig vascular endothelium plays a role in binding and phagocytosis of human platelets.
      Title: Porcine extrahepatic vascular endothelial asialoglycoprotein receptor 1 mediates xenogeneic platelet phagocytosis in vitro and in human-to-pig ex vivo xenoperfusion.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables D-mannose binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables fucose binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological process involved in interspecies interaction between organisms IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    asialoglycoprotein receptor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001244458.1 → NP_001231387.1  asialoglycoprotein receptor 1

      See identical proteins and their annotated locations for NP_001231387.1

      Status: VALIDATED

      Source sequence(s)
      AK233544
      UniProtKB/TrEMBL
      A0A8D0YBQ4
      Related
      ENSSSCP00000024884.1, ENSSSCT00000030763.4
      Conserved Domains (2) summary
      cd03590
      Location:153 → 278
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      pfam03954
      Location:18 → 143
      Lectin_N; Hepatic lectin, N-terminal domain

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010454.4 Reference Sscrofa11.1 Primary Assembly

      Range
      52536738..52540636 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_013987940.2 → XP_013843394.1  asialoglycoprotein receptor 1 isoform X1

      UniProtKB/TrEMBL
      A0A8D0SEI6
      Conserved Domains (2) summary
      cd03590
      Location:153 → 284
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      pfam03954
      Location:18 → 143
      Lectin_N; Hepatic lectin, N-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Research Materials