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    CRYAB crystallin alpha B [ Sus scrofa (pig) ]

    Gene ID: 100519789, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CRYABprovided by VGNC
    Official Full Name
    crystallin alpha Bprovided by VGNC
    Primary source
    VGNC:VGNC:87013
    See related
    Ensembl:ENSSSCG00000036724
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Biased expression in heart (RPKM 821.6), psoas major muscle (RPKM 775.0) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See CRYAB in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 9 NC_010451.4 (39638505..39643530, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 9 NC_010451.3 (44428979..44433758, complement)

    Chromosome 9 - NC_010451.4Genomic Context describing neighboring genes Neighboring gene ALG9 alpha-1,2-mannosyltransferase Neighboring gene ferredoxin-fold anticodon binding domain containing 1 Neighboring gene cilia and flagella associated protein 68 Neighboring gene chromosome 9 C11orf52 homolog Neighboring gene heat shock protein family B (small) member 2 Neighboring gene DIX domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. COOH-terminal truncations and site-directed mutations enhance thermostability and chaperone-like activity of porcine alphaB-crystallin. Liao JH, et al. Mol Vis, 2009 Jul 28. PMID 19641632, Free PMC Article
    2. Overexpression of alphaB crystallin in the gastrointestinal tract of the newborn piglet after hypoxia. Nefti O, et al. Shock, 2005 Nov. PMID 16247332
    3. Characterization, cloning, and expression of porcine alpha B crystallin. Liao JH, et al. Biochem Biophys Res Commun, 1998 Mar 6. PMID 9514893
    4. Retinoschisin forms a multi-molecular complex with extracellular matrix and cytoplasmic proteins: interactions with beta2 laminin and alphaB-crystallin. Steiner-Champliaud MF, et al. Mol Vis, 2006 Aug 10. PMID 16917482
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables structural constituent of eye lens IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein refolding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to heat IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alpha-crystallin B chain
    Names
    Alpha(B)-crystallin
    Alpha-crystallin B chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010451.4 Reference Sscrofa11.1 Primary Assembly

      Range
      39638505..39643530 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021062778.1 → XP_020918437.1  alpha-crystallin B chain

      UniProtKB/Swiss-Prot
      Q7M2W6
      UniProtKB/TrEMBL
      A0A8D1GP30, B1Q039
      Related
      ENSSSCP00000035382.1, ENSSSCT00000059078.3
      Conserved Domains (2) summary
      cd06498
      Location:67 → 150
      ACD_alphaB-crystallin_HspB5; Alpha-crystallin domain found in the small heat shock protein (sHsp) alphaB-crystallin (HspB5, 20kDa). sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers ...
      pfam00525
      Location:1 → 51
      Crystallin; Alpha crystallin A chain, N terminal

    2. XM_005667319.2 → XP_005667376.1  alpha-crystallin B chain

      See identical proteins and their annotated locations for XP_005667376.1

      UniProtKB/Swiss-Prot
      Q7M2W6
      UniProtKB/TrEMBL
      A0A8D1GP30, B1Q039
      Conserved Domains (2) summary
      cd06498
      Location:67 → 150
      ACD_alphaB-crystallin_HspB5; Alpha-crystallin domain found in the small heat shock protein (sHsp) alphaB-crystallin (HspB5, 20kDa). sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers ...
      pfam00525
      Location:1 → 51
      Crystallin; Alpha crystallin A chain, N terminal

    3. XM_021062779.1 → XP_020918438.1  alpha-crystallin B chain

      UniProtKB/Swiss-Prot
      Q7M2W6
      UniProtKB/TrEMBL
      A0A8D1GP30, B1Q039
      Conserved Domains (2) summary
      cd06498
      Location:67 → 150
      ACD_alphaB-crystallin_HspB5; Alpha-crystallin domain found in the small heat shock protein (sHsp) alphaB-crystallin (HspB5, 20kDa). sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers ...
      pfam00525
      Location:1 → 51
      Crystallin; Alpha crystallin A chain, N terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7M2W6.1 GenPept UniProtKB/Swiss-Prot:Q7M2W6

    Gene LinkOut

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