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    SLC12A2 solute carrier family 12 member 2 [ Sus scrofa (pig) ]

    Gene ID: 100516960, updated on 17-Aug-2024

    Summary

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    Official Symbol
    SLC12A2provided by VGNC
    Official Full Name
    solute carrier family 12 member 2provided by VGNC
    Primary source
    VGNC:VGNC:92922
    See related
    Ensembl:ENSSSCG00000014255
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Broad expression in longissimus dorsi muscle (RPKM 17.7), psoas major muscle (RPKM 12.7) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See SLC12A2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 2 NC_010444.4 (131016430..131109307)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 2 NC_010444.3 (136368254..136460658)

    Chromosome 2 - NC_010444.4Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L26 pseudogene Neighboring gene uncharacterized LOC106509551 Neighboring gene uncharacterized LOC100516424 Neighboring gene uncharacterized LOC102162098 Neighboring gene fibrillin 2 Neighboring gene uncharacterized LOC110259470 Neighboring gene solute carrier family 27 member 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ammonium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables sodium:potassium:chloride symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell volume homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in chloride ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in potassium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in potassium ion import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sodium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    solute carrier family 12 member 2
    Names
    solute carrier family 12 (sodium/potassium/chloride transporters), member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010444.4 Reference Sscrofa11.1 Primary Assembly

      Range
      131016430..131109307
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003123899.5 → XP_003123947.1  solute carrier family 12 member 2 isoform X1

      UniProtKB/TrEMBL
      A0A480HW11, A0A8D0Y129, A0A8D1UYF1, F1RKK2
      Related
      ENSSSCP00000015164.5, ENSSSCT00000015576.5
      Conserved Domains (3) summary
      TIGR00930
      Location:206 → 1202
      2a30; K-Cl cotransporter
      pfam03522
      Location:791 → 1202
      SLC12; Solute carrier family 12
      pfam08403
      Location:192 → 253
      AA_permease_N; Amino acid permease N-terminal

    2. XM_005661615.2 → XP_005661672.1  solute carrier family 12 member 2 isoform X2

      UniProtKB/TrEMBL
      A0A287AEN4, A0A8D0XXB6, A0A8D1HWQ0
      Related
      ENSSSCP00000042341.2, ENSSSCT00000059173.3
      Conserved Domains (3) summary
      TIGR00930
      Location:206 → 1186
      2a30; K-Cl cotransporter
      pfam03522
      Location:791 → 1186
      SLC12; Solute carrier family 12
      pfam08403
      Location:192 → 253
      AA_permease_N; Amino acid permease N-terminal
    Nucleotide Protein
    Heading Accession and Version

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