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    SMO smoothened, frizzled class receptor [ Sus scrofa (pig) ]

    Gene ID: 100515110, updated on 17-Aug-2024

    Summary

    Official Symbol
    SMOprovided by VGNC
    Official Full Name
    smoothened, frizzled class receptorprovided by VGNC
    Primary source
    VGNC:VGNC:93258
    See related
    Ensembl:ENSSSCG00000016569
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Broad expression in ovary (RPKM 31.6), kidney (RPKM 10.2) and 7 other tissues See more
    Orthologs
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    Genomic context

    See SMO in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 18 NC_010460.4 (19450730..19478796, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 18 NC_010460.3 (20520306..20548303, complement)

    Chromosome 18 - NC_010460.4Genomic Context describing neighboring genes Neighboring gene striatin interacting protein 2 Neighboring gene adenosylhomocysteinase like 2 Neighboring gene tetraspanin 33 Neighboring gene 40S ribosomal protein S20 pseudogene Neighboring gene transportin 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    General gene information

    Markers

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables patched binding IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in central nervous system development IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in commissural neuron axon guidance IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in positive regulation of smoothened signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in smoothened signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    PubMed 

    General protein information

    Preferred Names
    smoothened homolog
    Names
    smoothened, frizzled family receptor
    smoothened, seven transmembrane spanning receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010460.4 Reference Sscrofa11.1 Primary Assembly

      Range
      19450730..19478796 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003134680.5XP_003134728.1  smoothened homolog

      UniProtKB/TrEMBL
      A0A4X1W062, A0A8D1U7L4, A0A8D1ZBL7, F1SMQ3
      Related
      ENSSSCP00000017553.2, ENSSSCT00000018039.5
      Conserved Domains (2) summary
      cd07451
      Location:67197
      CRD_SMO; Cysteine-rich domain of the smoothened receptor (Smo) integral membrane protein
      pfam01534
      Location:222551
      Frizzled; Frizzled/Smoothened family membrane region