Dgkq diacylglycerol kinase, theta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dgkqprovided by RGD
Official Full Name: diacylglycerol kinase, thetaprovided by RGD
Primary source: RGD:2320722
See related: EnsemblRapid:ENSRNOG00000024112 AllianceGenome:RGD:2320722
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables ATP-dependent diacylglycerol kinase activity. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; regulation of gene expression; and regulation of steroid metabolic process. Located in nuclear matrix and nuclear speck. Orthologous to human DGKQ (diacylglycerol kinase theta). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 138.9), Liver (RPKM 136.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p22

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (1203380..1217536)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (1059125..1073131)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (2069409..2083370)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

nuclear DGK-theta is a down-stream target of nerve growth factor signaling in PC12 cells.
Title: Nuclear diacylglycerol kinase-theta is activated in response to nerve growth factor stimulation of PC12 cells.

Submit: New GeneRIF Correction

General gene information

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Markers

RH129524 (e-PCR)
- UniSTS:212826

RH141347 (e-PCR)
- UniSTS:223343

Dgkq (e-PCR), detects polymorphism
- UniSTS:546735

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent diacylglycerol kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent diacylglycerol kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ATP-dependent diacylglycerol kinase activity	ISO Inferred from Sequence Orthology more info
enables ATP-dependent diacylglycerol kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phospholipase binding	ISO Inferred from Sequence Orthology more info
enables transmembrane receptor protein tyrosine kinase activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to bile acid	ISO Inferred from Sequence Orthology more info
involved_in diacylglycerol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in diacylglycerol metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in glycerolipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycerolipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in lipid phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in phosphatidic acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidic acid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of cortisol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of progesterone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle endocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in thrombin-activated receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear matrix	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nuclear speck	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
located_in vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: diacylglycerol kinase theta

Names: DAG kinase theta; DGKtheta

NP_001185733.1

EC 2.7.1.107

EC 2.7.1.93

XP_038947472.1

EC 2.7.1.107

EC 2.7.1.93

XP_038947473.1

EC 2.7.1.107

EC 2.7.1.93

XP_038947474.1

EC 2.7.1.107

EC 2.7.1.93

XP_038947475.1

EC 2.7.1.107

EC 2.7.1.93

XP_038947477.1

EC 2.7.1.107

EC 2.7.1.93

XP_038947479.1

EC 2.7.1.107

EC 2.7.1.93

XP_038947480.1

EC 2.7.1.107

EC 2.7.1.93

XP_063128859.1

EC 2.7.1.107

EC 2.7.1.93

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001198804.1 → NP_001185733.1 diacylglycerol kinase theta

See identical proteins and their annotated locations for NP_001185733.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

D3ZEY4

Related

ENSRNOP00000108077.1, ENSRNOT00000155561.1

Conserved Domains (7) summary

smart00045
Location:736 → 888

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:585 → 709

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

cd01783
Location:392 → 486

RA2_DAGK-theta; Ras-associating (RA) domain 2 found in diacylgylcerol kinase theta (DAGK-theta) and similar proteins

cd17111
Location:293 → 389

RA1_DAGK-theta; Ras-associating (RA) domain 1 found in diacylgylcerol kinase theta (DAGK-theta) and similar proteins

cd20803
Location:54 → 107

C1_DGKtheta_typeV_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins

cd20804
Location:111 → 166

C1_DGKtheta_typeV_rpt2; second protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins

cd20854
Location:178 → 240

C1_DGKtheta_typeV_rpt3; third protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

1203380..1217536

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272789.1 → XP_063128859.1 diacylglycerol kinase theta isoform X6
XM_039091552.2 → XP_038947480.1 diacylglycerol kinase theta isoform X8

Conserved Domains (5) summary

cd01783
Location:392 → 486

RA2_DAGK-theta; Ras-associating (RA) domain 2 found in diacylgylcerol kinase theta (DAGK-theta) and similar proteins

cd17111
Location:293 → 389

RA1_DAGK-theta; Ras-associating (RA) domain 1 found in diacylgylcerol kinase theta (DAGK-theta) and similar proteins

cd20803
Location:54 → 107

C1_DGKtheta_typeV_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins

cd20804
Location:111 → 166

C1_DGKtheta_typeV_rpt2; second protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins

cd20854
Location:178 → 240

C1_DGKtheta_typeV_rpt3; third protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins
XM_039091551.2 → XP_038947479.1 diacylglycerol kinase theta isoform X7

Conserved Domains (5) summary

cd01783
Location:392 → 486

RA2_DAGK-theta; Ras-associating (RA) domain 2 found in diacylgylcerol kinase theta (DAGK-theta) and similar proteins

cd17111
Location:293 → 389

RA1_DAGK-theta; Ras-associating (RA) domain 1 found in diacylgylcerol kinase theta (DAGK-theta) and similar proteins

cd20803
Location:54 → 107

C1_DGKtheta_typeV_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins

cd20804
Location:111 → 166

C1_DGKtheta_typeV_rpt2; second protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins

cd20854
Location:178 → 240

C1_DGKtheta_typeV_rpt3; third protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins
XM_039091545.2 → XP_038947473.1 diacylglycerol kinase theta isoform X2

Conserved Domains (7) summary

smart00045
Location:770 → 922

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:621 → 743

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

cd01783
Location:392 → 486

RA2_DAGK-theta; Ras-associating (RA) domain 2 found in diacylgylcerol kinase theta (DAGK-theta) and similar proteins

cd17111
Location:293 → 389

RA1_DAGK-theta; Ras-associating (RA) domain 1 found in diacylgylcerol kinase theta (DAGK-theta) and similar proteins

cd20803
Location:54 → 107

C1_DGKtheta_typeV_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins

cd20804
Location:111 → 166

C1_DGKtheta_typeV_rpt2; second protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins

cd20854
Location:178 → 240

C1_DGKtheta_typeV_rpt3; third protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins
XM_039091546.2 → XP_038947474.1 diacylglycerol kinase theta isoform X3

Conserved Domains (7) summary

smart00045
Location:759 → 911

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:608 → 732

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

cd01783
Location:392 → 486

RA2_DAGK-theta; Ras-associating (RA) domain 2 found in diacylgylcerol kinase theta (DAGK-theta) and similar proteins

cd17111
Location:293 → 389

RA1_DAGK-theta; Ras-associating (RA) domain 1 found in diacylgylcerol kinase theta (DAGK-theta) and similar proteins

cd20803
Location:54 → 107

C1_DGKtheta_typeV_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins

cd20804
Location:111 → 166

C1_DGKtheta_typeV_rpt2; second protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins

cd20854
Location:178 → 240

C1_DGKtheta_typeV_rpt3; third protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins
XM_039091544.2 → XP_038947472.1 diacylglycerol kinase theta isoform X1

Conserved Domains (7) summary

smart00045
Location:772 → 924

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:621 → 745

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

cd01783
Location:392 → 486

RA2_DAGK-theta; Ras-associating (RA) domain 2 found in diacylgylcerol kinase theta (DAGK-theta) and similar proteins

cd17111
Location:293 → 389

RA1_DAGK-theta; Ras-associating (RA) domain 1 found in diacylgylcerol kinase theta (DAGK-theta) and similar proteins

cd20803
Location:54 → 107

C1_DGKtheta_typeV_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins

cd20804
Location:111 → 166

C1_DGKtheta_typeV_rpt2; second protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins

cd20854
Location:178 → 240

C1_DGKtheta_typeV_rpt3; third protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins
XM_039091547.2 → XP_038947475.1 diacylglycerol kinase theta isoform X4

Related

ENSRNOP00000036466.5, ENSRNOT00000032056.7

Conserved Domains (7) summary

smart00045
Location:723 → 875

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:572 → 696

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

cd01783
Location:392 → 486

RA2_DAGK-theta; Ras-associating (RA) domain 2 found in diacylgylcerol kinase theta (DAGK-theta) and similar proteins

cd17111
Location:293 → 389

RA1_DAGK-theta; Ras-associating (RA) domain 1 found in diacylgylcerol kinase theta (DAGK-theta) and similar proteins

cd20803
Location:54 → 107

C1_DGKtheta_typeV_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins

cd20804
Location:111 → 166

C1_DGKtheta_typeV_rpt2; second protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins

cd20854
Location:178 → 240

C1_DGKtheta_typeV_rpt3; third protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins
XM_039091549.2 → XP_038947477.1 diacylglycerol kinase theta isoform X5

Conserved Domains (7) summary

smart00045
Location:634 → 786

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:483 → 607

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

cd17111
Location:293 → 389

RA1_DAGK-theta; Ras-associating (RA) domain 1 found in diacylgylcerol kinase theta (DAGK-theta) and similar proteins

cd20803
Location:54 → 107

C1_DGKtheta_typeV_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins

cd20804
Location:111 → 166

C1_DGKtheta_typeV_rpt2; second protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins

cd20854
Location:178 → 240

C1_DGKtheta_typeV_rpt3; third protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins

cl28922
Location:392 → 471

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold