Nps neuropeptide S [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Npsprovided by RGD
Official Full Name: neuropeptide Sprovided by RGD
Primary source: RGD:2324597
See related: EnsemblRapid:ENSRNOG00000036653 AllianceGenome:RGD:2324597
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Involved in positive regulation of circadian sleep/wake cycle, wakefulness. Predicted to be located in synapse. Used to study morphine dependence. Orthologous to human NPS (neuropeptide S). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human mouse all
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Genomic context

Location:: 1q41

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (199505772..199510915)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (190077040..190080821)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (207508414..207512195)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The regulatory role of central neuropeptide-S in locomotion.
Title: The regulatory role of central neuropeptide-S in locomotion.
Neuropeptide S facilitates extinction of fear via modulation of mesolimbic dopaminergic circuitry.
Title: Neuropeptide S facilitates extinction of fear via modulation of mesolimbic dopaminergic circuitry.
The effect of chronic neuropeptide-S treatment on non-motor parameters in experimental model of Parkinson's disease.
Title: The effect of chronic neuropeptide-S treatment on non-motor parameters in experimental model of Parkinson's disease.
Electroacupuncture suppresses the pain and pain-related anxiety of chronic inflammation in rats by increasing the expression of the NPS/NPSR system in the ACC.
Title: Electroacupuncture suppresses the pain and pain-related anxiety of chronic inflammation in rats by increasing the expression of the NPS/NPSR system in the ACC.
study extends the knowledge about the intracellular signaling mechanisms underlying the potent anxiolytic profile of neuropeptide S
Title: Neuropeptide S Induces Acute Anxiolysis by Phospholipase C-Dependent Signaling within the Medial Amygdala.
(1) NPS efficiently prevents development of and reverses the posttraumatic stress symptomatology caused by exposure to stress; (2) the mechanisms of action involve both the NPS receptor and NPY-Y1R; and (3) NPS may affect the NPY-Y1R, indicating a possible cross talk between the NPYergic system and NPS. Treatment with NPS may be a novel approach for the treatment of the deleterious consequences of stress exposure.
Title: Neuropeptide S in the basolateral amygdala mediates an adaptive behavioral stress response in a rat model of posttraumatic stress disorder by increasing the expression of BDNF and the neuropeptide YY1 receptor.
Neuropeptide S (NPS) increases motor activity and thermogenesis in the rat through sympathetic activation. These results suggest that NPS contributes to the regulation of the sympathetic nervous system.
Title: Neuropeptide S increases motor activity and thermogenesis in the rat through sympathetic activation.
Intracerebroventricular (i.c.v.) NPS evoked a significant somatodendritic release of oxytocin within the paraventricular nucleus. The anxiolytic effects of NPS within the hypothalamic PVN are mediated via actions on local oxytocin neurons in male Wistar rats.
Title: Neuropeptide S Activates Paraventricular Oxytocin Neurons to Induce Anxiolysis.
Our study identified a protective role for NPS in amygdala against the development of NP, possibly attributing to its anti-inflammatory activity and inhibition of spinal microglia and astrocytes
Title: Intra-amygdala microinfusion of neuropeptide S attenuates neuropathic pain and suppresses the response of spinal microglia and astrocytes after spinal nerve ligation in rats.
Present results suggest a selective activation of one of the three neuropeptide S-expressing neuron clusters as well as release of neuropeptide S in distinct forebrain regions after sleep deprivation.
Title: Exploring the role of neuropeptide S in the regulation of arousal: a functional anatomical study.

Submit: New GeneRIF Correction See all GeneRIFs (19)

General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of action potential	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of action potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of circadian sleep/wake cycle, wakefulness	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synaptic transmission, GABAergic	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of synaptic transmission, GABAergic	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
acts_upstream_of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within visual learning	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neuropeptide S

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.