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    SMAD2 SMAD family member 2 [ Oryctolagus cuniculus (rabbit) ]

    Gene ID: 100359137, updated on 10-Oct-2024

    Summary

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    Gene symbol
    SMAD2
    Gene description
    SMAD family member 2
    See related
    Ensembl:ENSOCUG00000011290
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Oryctolagus cuniculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
    Orthologs
    human mouse all
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    Genomic context

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    See SMAD2 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) 9 NC_067382.1 (27076131..27176675)

    Chromosome 9 - NC_067382.1Genomic Context describing neighboring genes Neighboring gene U1 spliceosomal RNA Neighboring gene 60S ribosomal protein L35-like Neighboring gene zinc finger and BTB domain containing 7C Neighboring gene 60S ribosomal protein L17-like Neighboring gene transcription initiation factor TFIID subunit 9-like Neighboring gene SKI family transcriptional corepressor 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_067382.1 Chromosome 9 Reference UM_NZW_1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization and functional analysis of SMAD2 regulation in hair follicle cycle in Angora rabbits. Bao Z, et al. Gene, 2021 Feb 20. PMID 33333220
    2. [Angiotensin-(1-7) reduced postangioplasty vascular fibrosis in abdominal aorta of rabbits]. Zeng WT, et al. Zhonghua Xin Xue Guan Bing Za Zhi, 2010 Jun. PMID 21033136

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Characterization and functional analysis of SMAD2 regulation in hair follicle cycle in Angora rabbits.
      Title: Characterization and functional analysis of SMAD2 regulation in hair follicle cycle in Angora rabbits.
    2. Angiotensin-(1-7) attenuates postangioplasty collagen synthesis in rabbits possibly through down-regulating the expression of TGF-beta1 and inhibiting the activation of Smad2 pathway.
      Title: [Angiotensin-(1-7) reduced postangioplasty vascular fibrosis in abdominal aorta of rabbits].
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables I-SMAD binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in SMAD protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of heteromeric SMAD protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mothers against decapentaplegic homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UM_NZW_1.0 Primary Assembly

    Genomic

    1. NC_067382.1 Reference UM_NZW_1.0 Primary Assembly

      Range
      27076131..27176675
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_051851972.1 → XP_051707932.1  mothers against decapentaplegic homolog 2 isoform X1

      UniProtKB/TrEMBL
      G1T109

    2. XM_051851976.1 → XP_051707936.1  mothers against decapentaplegic homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A5F9C5D5

    3. XM_051851973.1 → XP_051707933.1  mothers against decapentaplegic homolog 2 isoform X1

      UniProtKB/TrEMBL
      G1T109

    4. XM_051851975.1 → XP_051707935.1  mothers against decapentaplegic homolog 2 isoform X1

      UniProtKB/TrEMBL
      G1T109

    5. XM_051851974.1 → XP_051707934.1  mothers against decapentaplegic homolog 2 isoform X1

      UniProtKB/TrEMBL
      G1T109

    6. XM_002713521.4 → XP_002713567.1  mothers against decapentaplegic homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_002713567.1

      UniProtKB/TrEMBL
      A0A5F9CQJ0, G1T109
      Related
      ENSOCUP00000009717.2
      Conserved Domains (2) summary
      cd10491
      Location:8 → 172
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:266 → 456
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
    Nucleotide Protein
    Heading Accession and Version

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