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    NFE2L2 NFE2 like bZIP transcription factor 2 [ Oryctolagus cuniculus (rabbit) ]

    Gene ID: 100353014, updated on 10-Oct-2024

    Summary

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    Gene symbol
    NFE2L2
    Gene description
    NFE2 like bZIP transcription factor 2
    See related
    Ensembl:ENSOCUG00000001009
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Oryctolagus cuniculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
    Also known as
    Nrf2
    Orthologs
    human mouse all
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    Genomic context

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    See NFE2L2 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) 7 NC_067380.1 (56500265..56684516)

    Chromosome 7 - NC_067380.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC127491743 Neighboring gene tetratricopeptide repeat protein 30B Neighboring gene alkylglycerone phosphate synthase Neighboring gene uncharacterized LOC127491742 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 Neighboring gene adenosine 5'-monophosphoramidase HINT1-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_067380.1 Chromosome 7 Reference UM_NZW_1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of Nrf2/ARE pathway in protective effect of electroacupuncture against endotoxic shock-induced acute lung injury in rabbits. Yu JB, et al. PLoS One, 2014. PMID 25115759, Free PMC Article
    2. Cyanidin-3-glucoside and its phenolic acid metabolites attenuate visible light-induced retinal degeneration in vivo via activation of Nrf2/HO-1 pathway and NF-κB suppression. Wang Y, et al. Mol Nutr Food Res, 2016 Jul. PMID 26991594
    3. Participation of protein kinase C in the activation of Nrf2 signaling by ischemic preconditioning in the isolated rabbit heart. Zhang X, et al. Mol Cell Biochem, 2013 Jan. PMID 23010891

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The expression of oxidative stress markers were upregulated after light exposure but attenuated by cyanidin-3-glucoside and ferulic acid, which may be attributed to the elevated secretion and expression of heme oxygenase (HO-1) and nuclear factor erythroid-2 related factor 2 (Nrf2).
      Title: Cyanidin-3-glucoside and its phenolic acid metabolites attenuate visible light-induced retinal degeneration in vivo via activation of Nrf2/HO-1 pathway and NF-κB suppression.
    2. electroacupuncture treatment at effectively attenuates lung injury in a model of endotoxic shock through activation of Nrf2/ARE pathway and following up-regulation of HO-1 expression
      Title: Role of Nrf2/ARE pathway in protective effect of electroacupuncture against endotoxic shock-induced acute lung injury in rabbits.
    3. Activation of PKC induces the translocation of Nrf2 and the enhancement of endogenous antioxidant defenses in ischemic preconditioned rabbit heart.
      Title: Participation of protein kinase C in the activation of Nrf2 signaling by ischemic preconditioning in the isolated rabbit heart.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nuclear factor erythroid 2-related factor 2
    Names
    nuclear factor (erythroid-derived 2)-like 2
    nuclear factor, erythroid 2 like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UM_NZW_1.0 Primary Assembly

    Genomic

    1. NC_067380.1 Reference UM_NZW_1.0 Primary Assembly

      Range
      56500265..56684516
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_051849401.1 → XP_051705361.1  nuclear factor erythroid 2-related factor 2 isoform X3

      UniProtKB/TrEMBL
      A0A5F9C9T3

    2. XM_051849400.1 → XP_051705360.1  nuclear factor erythroid 2-related factor 2 isoform X2

      UniProtKB/TrEMBL
      U3KP15

    3. XM_051849404.1 → XP_051705364.1  nuclear factor erythroid 2-related factor 2 isoform X4

    4. XM_051849403.1 → XP_051705363.1  nuclear factor erythroid 2-related factor 2 isoform X4

    5. XM_051849402.1 → XP_051705362.1  nuclear factor erythroid 2-related factor 2 isoform X4

    6. XM_051849399.1 → XP_051705359.1  nuclear factor erythroid 2-related factor 2 isoform X1

    7. XM_002712305.4 → XP_002712351.2  nuclear factor erythroid 2-related factor 2 isoform X5

      UniProtKB/TrEMBL
      A0A5J6KN37, G1SEJ1
      Related
      ENSOCUP00000000873.3
      Conserved Domains (1) summary
      cd14720
      Location:490 → 557
      bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain

    8. XM_008258785.3 → XP_008257007.1  nuclear factor erythroid 2-related factor 2 isoform X6

      UniProtKB/TrEMBL
      A0A5J6KN37
      Related
      ENSOCUP00000030547.1
      Conserved Domains (1) summary
      cd14720
      Location:474 → 541
      bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
    Nucleotide Protein
    Heading Accession and Version

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