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    NTRK2 neurotrophic receptor tyrosine kinase 2 [ Oryctolagus cuniculus (rabbit) ]

    Gene ID: 100352548, updated on 10-Oct-2024

    Summary

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    Gene symbol
    NTRK2
    Gene description
    neurotrophic receptor tyrosine kinase 2
    See related
    Ensembl:ENSOCUG00000009736
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Oryctolagus cuniculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
    Orthologs
    human mouse all
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    Genomic context

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    See NTRK2 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) Unplaced Scaffold NW_026259176.1 (2212659..2601945)

    NW_026259176.1Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein K Neighboring gene RecQ mediated genome instability 1 Neighboring gene solute carrier family 28 member 3 Neighboring gene uncharacterized LOC127487615 Neighboring gene uncharacterized LOC127487605 Neighboring gene uncharacterized LOC103352411

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_026259176 Unplaced Scaffold Reference UM_NZW_1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables axon guidance receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables brain-derived neurotrophic factor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables brain-derived neurotrophic factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to brain-derived neurotrophic factor stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in synapse organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in trans-synaptic signaling by neuropeptide, modulating synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    BDNF/NT-3 growth factors receptor
    Names
    neurotrophic tyrosine kinase, receptor, type 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UM_NZW_1.0 Primary Assembly

    Genomic

    1. NW_026259176.1 Reference UM_NZW_1.0 Primary Assembly

      Range
      2212659..2601945
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_051833735.1 → XP_051689695.1  BDNF/NT-3 growth factors receptor isoform X1

      UniProtKB/TrEMBL
      G1SXT8

    2. XM_051833733.1 → XP_051689693.1  BDNF/NT-3 growth factors receptor isoform X1

      UniProtKB/TrEMBL
      G1SXT8

    3. XM_017350807.2 → XP_017206296.1  BDNF/NT-3 growth factors receptor isoform X2

      UniProtKB/TrEMBL
      A0A5F9D297, A0A5F9DDW5
      Related
      ENSOCUP00000044455.1
      Conserved Domains (7) summary
      cd05855
      Location:301 → 379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      smart00408
      Location:210 → 273
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:204 → 283
      IG_like; Immunoglobulin like
      cd05093
      Location:532 → 819
      PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
      pfam07714
      Location:538 → 807
      Pkinase_Tyr; Protein tyrosine kinase
      pfam13855
      Location:92 → 150
      LRR_8; Leucine rich repeat
      pfam16920
      Location:152 → 195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    4. XM_051833737.1 → XP_051689697.1  BDNF/NT-3 growth factors receptor isoform X4

      UniProtKB/TrEMBL
      A0A5F9CQJ2

    5. XM_051833738.1 → XP_051689698.1  BDNF/NT-3 growth factors receptor isoform X5

    6. XM_051833739.1 → XP_051689699.1  BDNF/NT-3 growth factors receptor isoform X6

      UniProtKB/TrEMBL
      A0A5F9CW66

    7. XM_051833734.1 → XP_051689694.1  BDNF/NT-3 growth factors receptor isoform X1

      UniProtKB/TrEMBL
      G1SXT8

    8. XM_051833736.1 → XP_051689696.1  BDNF/NT-3 growth factors receptor isoform X3

    Nucleotide Protein
    Heading Accession and Version

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