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    APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 [ Oryctolagus cuniculus (rabbit) ]

    Gene ID: 100348924, updated on 8-Mar-2024

    Summary

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    Gene symbol
    APEX1
    Gene description
    apurinic/apyrimidinic endodeoxyribonuclease 1
    See related
    Ensembl:ENSOCUG00000005022
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Oryctolagus cuniculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
    Orthologs
    human mouse all
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    Genomic context

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    See APEX1 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) 17 NC_067390.1 (41822323..41825710)

    Chromosome 17 - NC_067390.1Genomic Context describing neighboring genes Neighboring gene kelch like family member 33 Neighboring gene uncharacterized LOC103351151 Neighboring gene O-sialoglycoprotein endopeptidase Neighboring gene phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 Neighboring gene purine nucleoside phosphorylase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_067390.1 Chromosome 17 Reference UM_NZW_1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables double-stranded DNA 3'-5' DNA exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in base-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-(apurinic or apyrimidinic site) endonuclease
    Names
    APEX nuclease (multifunctional DNA repair enzyme) 1
    APEX nuclease 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UM_NZW_1.0 Primary Assembly

    Genomic

    1. NC_067390.1 Reference UM_NZW_1.0 Primary Assembly

      Range
      41822323..41825710
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008269300.3 → XP_008267522.1  DNA-(apurinic or apyrimidinic site) endonuclease

      See identical proteins and their annotated locations for XP_008267522.1

      UniProtKB/TrEMBL
      G1SN16
      Conserved Domains (1) summary
      cd09087
      Location:62 → 316
      Ape1-like_AP-endo; Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases

    2. XM_008269301.3 → XP_008267523.1  DNA-(apurinic or apyrimidinic site) endonuclease

      See identical proteins and their annotated locations for XP_008267523.1

      UniProtKB/TrEMBL
      G1SN16
      Related
      ENSOCUP00000004349.2
      Conserved Domains (1) summary
      cd09087
      Location:62 → 316
      Ape1-like_AP-endo; Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases
    Nucleotide Protein
    Heading Accession and Version

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