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    MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 [ Oryctolagus cuniculus (rabbit) ]

    Gene ID: 100347271, updated on 8-Mar-2024

    Summary

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    Gene symbol
    MTHFD1
    Gene description
    methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
    See related
    Ensembl:ENSOCUG00000011720
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Oryctolagus cuniculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
    Orthologs
    human mouse all
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    Genomic context

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    See MTHFD1 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) 20 NC_067393.1 (11766802..11833909)

    Chromosome 20 - NC_067393.1Genomic Context describing neighboring genes Neighboring gene estrogen receptor 2 Neighboring gene coiled-coil domain-containing protein 170 Neighboring gene small nucleolar RNA SNORA74 Neighboring gene A-kinase anchoring protein 5 Neighboring gene zinc finger and BTB domain containing 25

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_067393.1 Chromosome 20 Reference UM_NZW_1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables formate-tetrahydrofolate ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables methenyltetrahydrofolate cyclohydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables methylenetetrahydrofolate dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tetrahydrofolate interconversion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    C-1-tetrahydrofolate synthase, cytoplasmic
    Names
    methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
    methylenetetrahydrofolate dehydrogenase 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UM_NZW_1.0 Primary Assembly

    Genomic

    1. NC_067393.1 Reference UM_NZW_1.0 Primary Assembly

      Range
      11766802..11833909
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008271884.3 → XP_008270106.1  C-1-tetrahydrofolate synthase, cytoplasmic isoform X1

      UniProtKB/TrEMBL
      G1T1U7
      Related
      ENSOCUP00000010081.2
      Conserved Domains (4) summary
      cd01080
      Location:120 → 292
      NAD_bind_m-THF_DH_Cyclohyd; NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
      PLN02759
      Location:310 → 935
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:6 → 294
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
      pfam00763
      Location:6 → 125
      THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain

    2. XM_051826093.1 → XP_051682053.1  C-1-tetrahydrofolate synthase, cytoplasmic isoform X2

    Nucleotide Protein
    Heading Accession and Version

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