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    LOC100347223 diacylglycerol kinase alpha [ Oryctolagus cuniculus (rabbit) ]

    Gene ID: 100347223, updated on 18-Sep-2024

    Summary

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    Gene symbol
    LOC100347223
    Gene description
    diacylglycerol kinase alpha
    See related
    Ensembl:ENSOCUG00000021918
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Oryctolagus cuniculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
    Also known as
    DGKA
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    Genomic context

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    See LOC100347223 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) Unplaced Scaffold NW_026259166.1 (4805363..4829352, complement)

    NW_026259166.1Genomic Context describing neighboring genes Neighboring gene ras-related protein Rab-5B Neighboring gene cyclin-dependent kinase 2 Neighboring gene melanocyte protein PMEL Neighboring gene partner of Y14 and mago Neighboring gene matrix metalloproteinase-19

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_026259166 Unplaced Scaffold Reference UM_NZW_1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP-dependent diacylglycerol kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in diacylglycerol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in lipid phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    diacylglycerol kinase alpha
    Names
    diacylglycerol kinase, alpha 80kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UM_NZW_1.0 Primary Assembly

    Genomic

    1. NW_026259166.1 Reference UM_NZW_1.0 Primary Assembly

      Range
      4805363..4829352 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008256620.3 → XP_008254842.1  diacylglycerol kinase alpha isoform X2

      See identical proteins and their annotated locations for XP_008254842.1

      UniProtKB/TrEMBL
      G1TRX7
      Conserved Domains (7) summary
      smart00045
      Location:519 → 700
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:377 → 498
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG1597
      Location:377 → 710
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
      cd00051
      Location:113 → 182
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:205 → 253
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam13499
      Location:114 → 178
      EF-hand_7; EF-hand domain pair
      pfam14513
      Location:6 → 109
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    2. XM_008256619.3 → XP_008254841.1  diacylglycerol kinase alpha isoform X2

      See identical proteins and their annotated locations for XP_008254841.1

      UniProtKB/TrEMBL
      G1TRX7
      Conserved Domains (7) summary
      smart00045
      Location:519 → 700
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:377 → 498
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG1597
      Location:377 → 710
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
      cd00051
      Location:113 → 182
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:205 → 253
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam13499
      Location:114 → 178
      EF-hand_7; EF-hand domain pair
      pfam14513
      Location:6 → 109
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    3. XM_008256621.3 → XP_008254843.1  diacylglycerol kinase alpha isoform X2

      See identical proteins and their annotated locations for XP_008254843.1

      UniProtKB/TrEMBL
      G1TRX7
      Related
      ENSOCUP00000019786.3
      Conserved Domains (7) summary
      smart00045
      Location:519 → 700
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:377 → 498
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG1597
      Location:377 → 710
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
      cd00051
      Location:113 → 182
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:205 → 253
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam13499
      Location:114 → 178
      EF-hand_7; EF-hand domain pair
      pfam14513
      Location:6 → 109
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    4. XM_002711059.4 → XP_002711105.2  diacylglycerol kinase alpha isoform X1

      UniProtKB/TrEMBL
      G1TRX7
      Conserved Domains (7) summary
      smart00045
      Location:557 → 738
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:415 → 536
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG1597
      Location:415 → 748
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
      cd00051
      Location:151 → 220
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:243 → 291
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam13499
      Location:152 → 216
      EF-hand_7; EF-hand domain pair
      pfam14513
      Location:44 → 147
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    5. XM_008256622.3 → XP_008254844.1  diacylglycerol kinase alpha isoform X3

      Conserved Domains (6) summary
      smart00046
      Location:415 → 536
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:151 → 220
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:243 → 291
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam13499
      Location:152 → 216
      EF-hand_7; EF-hand domain pair
      pfam14513
      Location:44 → 147
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cl02440
      Location:557 → 618
      DAGK_acc; Diacylglycerol kinase accessory domain
    Nucleotide Protein
    Heading Accession and Version

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