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    PDE8A phosphodiesterase 8A [ Oryctolagus cuniculus (rabbit) ]

    Gene ID: 100343099, updated on 10-Oct-2024

    Summary

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    Gene symbol
    PDE8A
    Gene description
    phosphodiesterase 8A
    See related
    Ensembl:ENSOCUG00000016908
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Oryctolagus cuniculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
    Orthologs
    human mouse all
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    Genomic context

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    See PDE8A in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) Unplaced Scaffold NW_026259185.1 (4029687..4180357, complement)

    NW_026259185.1Genomic Context describing neighboring genes Neighboring gene cytoplasmic polyadenylation element binding protein 1 Neighboring gene ribosomal protein S17 Neighboring gene solute carrier family 28 member 1 Neighboring gene uncharacterized LOC103352496 Neighboring gene alpha kinase 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_026259185 Unplaced Scaffold Reference UM_NZW_1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to epidermal growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UM_NZW_1.0 Primary Assembly

    Genomic

    1. NW_026259185.1 Reference UM_NZW_1.0 Primary Assembly

      Range
      4029687..4180357 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002721497.4 → XP_002721543.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1

      UniProtKB/TrEMBL
      A0A5F9CAW3, G1TCL6
      Related
      ENSOCUP00000014530.3
      Conserved Domains (6) summary
      COG0745
      Location:89 → 176
      OmpR; DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription]
      cd00130
      Location:237 → 331
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00233
      Location:562 → 814
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08629
      Location:1 → 41
      PDE8; PDE8 phosphodiesterase
      pfam13426
      Location:233 → 331
      PAS_9; PAS domain
      cl19078
      Location:90 → 176
      REC; Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; ...

    2. XM_051834237.1 → XP_051690197.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3

      UniProtKB/TrEMBL
      A0A5F9DC82

    3. XM_051834238.1 → XP_051690198.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X4

    4. XM_051834236.1 → XP_051690196.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X2

    Nucleotide Protein
    Heading Accession and Version

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