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    NOX4 NADPH oxidase 4 [ Oryctolagus cuniculus (rabbit) ]

    Gene ID: 100339697, updated on 6-Jun-2024

    Summary

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    Gene symbol
    NOX4
    Gene description
    NADPH oxidase 4
    See related
    Ensembl:ENSOCUG00000016685
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Oryctolagus cuniculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
    Orthologs
    human mouse all
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    Genomic context

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    See NOX4 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) 1 NC_067374.1 (141242358..141457715)

    Chromosome 1 - NC_067374.1Genomic Context describing neighboring genes Neighboring gene Putative N-acetylated-alpha-linked acidic dipeptidase Neighboring gene tripartite motif containing 77 Neighboring gene U6 spliceosomal RNA Neighboring gene U6 snRNA-associated Sm-like protein LSm6 Neighboring gene tyrosinase Neighboring gene 40S ribosomal protein S24-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_067374.1 Chromosome 1 Reference UM_NZW_1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Proteasome inhibition represses unfolded protein response and Nox4, sensitizing vascular cells to endoplasmic reticulum stress-induced death. Amanso AM, et al. PLoS One, 2011 Jan 26. PMID 21297867, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. proteasome inhibition completely prevented endoplasmic reticulum stress-induced increase in NADPH oxidase activity, as well as increases in Nox4 isoform and protein disulfide isomerase mRNA expression
      Title: Proteasome inhibition represses unfolded protein response and Nox4, sensitizing vascular cells to endoplasmic reticulum stress-induced death.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables superoxide-generating NAD(P)H oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in superoxide anion generation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NADPH oxidase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NADPH oxidase 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UM_NZW_1.0 Primary Assembly

    Genomic

    1. NC_067374.1 Reference UM_NZW_1.0 Primary Assembly

      Range
      141242358..141457715
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_051820918.1 → XP_051676878.1  NADPH oxidase 4 isoform X2

      UniProtKB/TrEMBL
      A0A5F9DBW4

    2. XM_051820907.1 → XP_051676867.1  NADPH oxidase 4 isoform X2

      UniProtKB/TrEMBL
      A0A5F9DBW4

    3. XM_051820929.1 → XP_051676889.1  NADPH oxidase 4 isoform X3

      UniProtKB/TrEMBL
      A0A5F9DBW4

    4. XM_002708641.4 → XP_002708687.1  NADPH oxidase 4 isoform X1

      UniProtKB/TrEMBL
      A0A5F9DAG7, A0A5F9DBW4
      Related
      ENSOCUP00000042271.1
      Conserved Domains (2) summary
      cd06186
      Location:311 → 577
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      pfam01794
      Location:69 → 204
      Ferric_reduct; Ferric reductase like transmembrane component

    5. XM_051820896.1 → XP_051676856.1  NADPH oxidase 4 isoform X2

      UniProtKB/TrEMBL
      A0A5F9DBW4
    Nucleotide Protein
    Heading Accession and Version

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