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    MARS1 methionyl-tRNA synthetase 1 [ Oryctolagus cuniculus (rabbit) ]

    Gene ID: 100338022, updated on 8-Mar-2024

    Summary

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    Gene symbol
    MARS1
    Gene description
    methionyl-tRNA synthetase 1
    See related
    Ensembl:ENSOCUG00000007373
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Oryctolagus cuniculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
    Also known as
    MARS
    Orthologs
    human mouse all
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    Genomic context

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    See MARS1 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) Unplaced Scaffold NW_026259166.1 (3424510..3444758, complement)

    NW_026259166.1Genomic Context describing neighboring genes Neighboring gene dynactin subunit 2 Neighboring gene methyl-CpG binding domain protein 6 Neighboring gene DNA damage inducible transcript 3 Neighboring gene Rho GTPase activating protein 9 Neighboring gene GLI family zinc finger 1 Neighboring gene inhibin subunit beta E

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_026259166 Unplaced Scaffold Reference UM_NZW_1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables methionine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in methionyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of aminoacyl-tRNA synthetase multienzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    methionine--tRNA ligase, cytoplasmic

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UM_NZW_1.0 Primary Assembly

    Genomic

    1. NW_026259166.1 Reference UM_NZW_1.0 Primary Assembly

      Range
      3424510..3444758 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002720913.4 → XP_002720959.1  methionine--tRNA ligase, cytoplasmic isoform X1

      UniProtKB/TrEMBL
      A0A5F9DTN5
      Related
      ENSOCUP00000049774.1
      Conserved Domains (7) summary
      cd07957
      Location:642 → 771
      Anticodon_Ia_Met; Anticodon-binding domain of methionyl tRNA synthetases
      cd00814
      Location:265 → 633
      MetRS_core; catalytic core domain of methioninyl-tRNA synthetases
      cd10307
      Location:77 → 179
      GST_C_MetRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of Methionyl-tRNA synthetase from higher eukaryotes
      COG0625
      Location:47 → 189
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      PRK12268
      Location:264 → 819
      PRK12268; methionyl-tRNA synthetase; Reviewed
      cd00939
      Location:853 → 897
      MetRS_RNA; MetRS_RNA binding domain. This short RNA-binding domain is found at the C-terminus of MetRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is repeated in Drosophila MetRS. This domain consists of a helix-turn-helix structure, which is ...
      cl00388
      Location:1 → 68
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    2. XM_002720914.4 → XP_002720960.1  methionine--tRNA ligase, cytoplasmic isoform X2

      UniProtKB/TrEMBL
      G1SSX5
      Related
      ENSOCUP00000006378.3
      Conserved Domains (7) summary
      cd07957
      Location:642 → 771
      Anticodon_Ia_Met; Anticodon-binding domain of methionyl tRNA synthetases
      cd00814
      Location:265 → 633
      MetRS_core; catalytic core domain of methioninyl-tRNA synthetases
      cd10307
      Location:77 → 179
      GST_C_MetRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of Methionyl-tRNA synthetase from higher eukaryotes
      COG0625
      Location:47 → 189
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      PRK12268
      Location:264 → 819
      PRK12268; methionyl-tRNA synthetase; Reviewed
      cd00939
      Location:845 → 889
      MetRS_RNA; MetRS_RNA binding domain. This short RNA-binding domain is found at the C-terminus of MetRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is repeated in Drosophila MetRS. This domain consists of a helix-turn-helix structure, which is ...
      cl00388
      Location:1 → 68
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    Nucleotide Protein
    Heading Accession and Version

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