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    map3k1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase [ Danio rerio (zebrafish) ]

    Gene ID: 100334486, updated on 18-Sep-2024

    Summary

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    Official Symbol
    map3k1provided by ZNC
    Official Full Name
    mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-090313-412
    See related
    Ensembl:ENSDARG00000098405 AllianceGenome:ZFIN:ZDB-GENE-090313-412
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:rp71-80a19.2
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in 46,XY sex reversal 6 and breast cancer. Orthologous to human MAP3K1 (mitogen-activated protein kinase kinase kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See map3k1 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (5904353..6006554)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (5903121..6005346)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 55 Neighboring gene uncharacterized LOC103908726 Neighboring gene 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) Neighboring gene DNA translocase FtsK 1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. G-quadruplexes as novel cis-elements controlling transcription during embryonic development. David AP, et al. Nucleic Acids Res, 2016 May 19. PMID 26773060, Free PMC Article
    2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase kinase kinase 1
    XP_005155564.1
    XP_068079989.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      5904353..6006554
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005155507.5 → XP_005155564.1  mitogen-activated protein kinase kinase kinase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B1Q9
      Conserved Domains (2) summary
      smart00220
      Location:1210 → 1475
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06630
      Location:1209 → 1476
      STKc_MEKK1; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1

    2. XM_068223888.1 → XP_068079989.1  mitogen-activated protein kinase kinase kinase 1 isoform X2

      Related
      ENSDARP00000136414.1, ENSDART00000161887.2
    Nucleotide Protein Strain
    Heading Accession and Version

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