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    gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 [ Danio rerio (zebrafish) ]

    Gene ID: 100331377, updated on 14-Apr-2024

    Summary

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    Official Symbol
    gabrb1provided by ZNC
    Official Full Name
    gamma-aminobutyric acid type A receptor subunit beta1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-090313-230
    See related
    Ensembl:ENSDARG00000076127 AllianceGenome:ZFIN:ZDB-GENE-090313-230
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-20i10.4
    Summary
    Predicted to enable neurotransmitter receptor activity. Predicted to contribute to GABA-A receptor activity and chloride channel activity. Predicted to be involved in several processes, including chemical synaptic transmission; chloride transmembrane transport; and regulation of membrane potential. Predicted to act upstream of or within chloride transport. Predicted to be located in postsynaptic membrane. Predicted to be integral component of membrane. Predicted to be part of GABA-A receptor complex. Predicted to be active in neuron projection and synapse. Predicted to be integral component of plasma membrane. Is expressed in brainstem and eye. Human ortholog(s) of this gene implicated in autistic disorder and developmental and epileptic encephalopathy 45. Orthologous to human GABRB1 (gamma-aminobutyric acid type A receptor subunit beta1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See gabrb1 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (12300005..12371661)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (12167568..12238907)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene gamma-aminobutyric acid type A receptor subunit alpha2a Neighboring gene gamma-aminobutyric acid type A receptor subunit gamma1 Neighboring gene COMM domain containing 8 Neighboring gene ATPase phospholipid transporting 10D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Flumazenil-insensitive benzodiazepine binding sites in GABA(A) receptors contribute to benzodiazepine-induced immobility in zebrafish larvae. Cao Y, et al. Life Sci, 2019 Dec 15. PMID 31697950
    2. Abamectin induces rapid and reversible hypoactivity within early zebrafish embryos. Raftery TD, et al. Neurotoxicol Teratol, 2015 May-Jun. PMID 25733401
    3. Expression of the eight GABAA receptor α subunits in the developing zebrafish central nervous system. Monesson-Olson B, et al. PLoS One, 2018. PMID 29702678, Free PMC Article
    4. Characterization of zebrafish GABA(A) receptor subunits. Sadamitsu K, et al. Sci Rep, 2021 Mar 18. PMID 33737538, Free PMC Article
    5. Chronic Exposure to Oxazepam Pollution Produces Tolerance to Anxiolytic Effects in Zebrafish (Danio rerio). Vossen LE, et al. Environ Sci Technol, 2020 Feb 4. PMID 31934760

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GABA-A receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GABA-A receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chloride channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables extracellular ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neurotransmitter receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within chloride transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of GABA-A receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of chloride channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transmembrane transporter complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    gamma-aminobutyric acid receptor subunit beta-1
    Names
    gamma-aminobutyric acid (GABA) A receptor, beta 1
    gamma-aminobutyric acid type A receptor beta1 subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      12300005..12371661
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021480764.1 → XP_021336439.1  gamma-aminobutyric acid receptor subunit beta-1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9QFU1
      Conserved Domains (1) summary
      cl27321
      Location:19 → 288
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

    2. XM_002664133.5 → XP_002664179.2  gamma-aminobutyric acid receptor subunit beta-1 isoform X1

      UniProtKB/TrEMBL
      A0A8M1RRD1, F1QPW7
      Related
      ENSDARP00000097944.2, ENSDART00000108535.4
      Conserved Domains (3) summary
      TIGR00860
      Location:19 → 482
      LIC; Cation transporter family protein
      pfam02931
      Location:49 → 250
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:257 → 479
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
    Nucleotide Protein Strain
    Heading Accession and Version

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