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    arfgef1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) [ Danio rerio (zebrafish) ]

    Gene ID: 100329953, updated on 2-Nov-2024

    Summary

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    Official Symbol
    arfgef1provided by ZNC
    Official Full Name
    ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-108
    See related
    Ensembl:ENSDARG00000063474 AllianceGenome:ZFIN:ZDB-GENE-030131-108
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zeh1651; hm:zeh1651; im:7138204; wu:fj64h08
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to act upstream of or within protein transport and regulation of ARF protein signal transduction. Predicted to be located in Golgi apparatus. Is expressed in brain. Orthologous to human ARFGEF1 (ADP ribosylation factor guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See arfgef1 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (18737138..18877076, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (18592719..18732663, complement)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing Neighboring gene centrosome and spindle pole associated protein 1 Neighboring gene si:dkey-4m13.3 Neighboring gene carboxypeptidase A6 Neighboring gene phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Involvement of BIG1 and BIG2 in regulating VEGF expression and angiogenesis. Lu FI, et al. FASEB J, 2019 Sep. PMID 31199673
    2. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of ARF protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    brefeldin A-inhibited guanine nucleotide-exchange protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      18737138..18877076 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068217191.1 → XP_068073292.1  brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X4

    2. XM_009297399.2 → XP_009295674.1  brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8M3AZ40, E7FGL2
      Related
      ENSDARP00000087215.4, ENSDART00000092783.7
      Conserved Domains (5) summary
      PLN03076
      Location:15 → 1809
      PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
      pfam01369
      Location:708 → 892
      Sec7; Sec7 domain
      pfam09324
      Location:1225 → 1306
      DUF1981; Domain of unknown function (DUF1981)
      pfam12783
      Location:429 → 583
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
      pfam16213
      Location:29 → 210
      DCB; Dimerization and cyclophilin-binding domain of Mon2

    3. XM_068217189.1 → XP_068073290.1  brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X2

    4. XM_009297395.2 → XP_009295670.1  brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A2R8Q904, A0A8M3AW02
      Related
      ENSDARP00000150827.1, ENSDART00000186269.1
      Conserved Domains (5) summary
      PLN03076
      Location:15 → 1827
      PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
      pfam01369
      Location:726 → 910
      Sec7; Sec7 domain
      pfam09324
      Location:1243 → 1324
      DUF1981; Domain of unknown function (DUF1981)
      pfam12783
      Location:447 → 601
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
      pfam16213
      Location:29 → 210
      DCB; Dimerization and cyclophilin-binding domain of Mon2
    Nucleotide Protein Strain
    Heading Accession and Version

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