SIRT4 sirtuin 4 [Ovis aries (sheep)] - Gene

Summary

Gene symbol: SIRT4
Gene description: sirtuin 4
See related: EnsemblRapid:ENSOARG00020021864
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Ovis aries
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	ARS-UI_Ramb_v3.0 (GCF_016772045.2)	17	NC_056070.1 (62760577..62779027)

Chromosome 17 - NC_056070.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_056070.1 Chromosome 17 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables NAD+ binding	IEA Inferred from Electronic Annotation more info	PubMed
enables NAD-dependent protein lysine deacetylase activity	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

NP_001156516.1

EC 2.3.1.-

EC 2.3.1.286

XP_060256566.1

EC 2.3.1.-

EC 2.3.1.286

XP_060256567.1

EC 2.3.1.-

EC 2.3.1.286

XP_060256568.1

EC 2.3.1.-

EC 2.3.1.286

XP_060256569.1

EC 2.3.1.-

EC 2.3.1.286

XP_060256570.1

EC 2.3.1.-

EC 2.3.1.286

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163044.1 → NP_001156516.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

See identical proteins and their annotated locations for NP_001156516.1

Status: PROVISIONAL

Source sequence(s)

FJ969402

UniProtKB/TrEMBL

A0A6P3CXJ3, A0A835ZXX7, C5IWT2, W5PQX2

Related

ENSOARP00020027935.2, ENSOART00020033852.2

Conserved Domains (1) summary

cd01409
Location:48 → 309

SIRT4; SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...

RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

NC_056070.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Range

62760577..62779027

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_060400584.1 → XP_060256567.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X1
XM_060400585.1 → XP_060256568.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X2

UniProtKB/TrEMBL

A0A835ZXX7, W5PQX2
XM_060400586.1 → XP_060256569.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X2

UniProtKB/TrEMBL

A0A835ZXX7, W5PQX2
XM_060400587.1 → XP_060256570.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X1
XM_060400583.1 → XP_060256566.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X1